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Abstract
The importance of reproductive and other health and social factors as predictors of
bone mineral density (BMD) and fractures was investigated in a longitudinal study
of 70-year-old women. At 70 years of age there was no correlation between menarcheal
age, menopausal age, duration of fertile period and parity and BMD or a history of
fractures. Bilateral oophorectomy (mean age at surgery 45.3 ± 3.6 years) and the duration
of tobacco smoking were negatively correlated to BMD at 70 years of age. Tobacco smoking
was positively correlated to a history of fractures and body mass index (BMI) was
negatively correlated to a history of fractures at 70 years of age. In a stepwise
multiple regression model, height, body mass index and a history of hysterectomy were
found to have a contributory, positively-correlated independent explanatory value
for BMD at 70 years. In a logistic multiple regression analysis, bilateral oophorectomy
was the only independent explanatory factor for fractures at 70 years of age. BMD
was lower in women who had undergone bilateral oophorectomy compared with controls
at 70 years of age. Hysterectomized women without bilateral oophorectomy showed a
higher BMD in the right calcaneus at 70 years of age compared with controls. When
comparing the reduction in bone mineral density between 70 and 76 years of age, the
fifth quintile (women with the highest BMD) at 70 years of age decreased 2.7 times
more (P < 0.01) than the first quintile. A longitudinal examination between 70 and 76 years
revealed that BMD at the age of 70 was a significant (P < 0.01) predictor for fractures occurring between 70 and 76 years of age.
Keywords
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Article info
Publication history
Accepted:
November 23,
1992
Received in revised form:
November 20,
1992
Received:
March 18,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
