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Abstract
This study investigated the effect of ageing and reduction in ovarian function on
whole blood serotonin levels and the effect of the oestrogen replacement in postmenopausal
women on blood serotonin levels. Amenorrbeic, natural postmenopausal and ovariectomised
women had lower blood serotonin levels than regularly menstruating women. Blood serotonin
levels increased after oestrogen replacement in postmenopausal women to values similar
to those observed in regularly menstruating women. In ovariec-tomised women, the blood
serotonin levels were inversely correlated with age (P < 0.01). In women with different serum oestradiol levels ranging 30–1335 pg/ml, a
direct relationship was observed between serum oestradiol levels and whole blood serotonin
levels (P < 0.001). It was concluded that whole blood serotonin concentration is reduced
during menopause by suppression of ovarian function but may also be an effect of ageing.
Keywords
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Article info
Publication history
Accepted:
November 20,
1992
Received in revised form:
July 7,
1992
Received:
January 29,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
