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Abstract
We evaluated serum total-, LDL-, HDL-, cholesterol and triglycerides in 858 women.
Sixty-seven were in premenopause, 307 in perimenopause, 326 in spontaneous menopause,
and 158 women underwent hysterectomy. Of these, 101 had bilateral ovariectomy, 24
with unilateral ovariectomy and 33 with retention of both ovaries. After correcting
for chronological age and body mass index by variance analysis, it was found that
total-, LDL- and HDL-cholesterol significantly increased during menopause without
changes in the total cholesterol/HDL-cholesterol, LDL-cholesterol/HDL-cholesterol
and triglycerides/HDL-cholesterol ratio. The changes gradually occurred during the
months preceding spontaneous cessation of menses. Atherogenic metabolic risk (as relative
risk of high total and LDL-cholesterol, estimated by logistic regression analysis)
significantly increased in all groups of women in reference to premenopause. The risk
observed in surgical menopause with bilateral ovariectomy was higher than in spontaneous
menopause, and conservation of ovaries in hysterectomized women seems to protect only
partially against such an increase.
Keywords
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References
- Menopause and coronary heart disease.Ann Intern Med. 1978; 89: 157-161
- Coronary heart disease during the menopause.in: Oliver MF Coronary heart disease in young women. Churchill Livingstone, New York1978: 234-239
- Early menopause and the risk of myocardial infarction.Am J Obstet Gynecol. 1981; 139: 47-51
- Menopause and the risk of coronary heart disease in women.N Engl J Med. 1987; 316: 1105-1110
- Increased risk of atherosclerosis in women after the menopause.Br Med J. 1989; 298: 642-644
- Oestrogen replacement therapy and cardiovascular disease in postmenopausal women.in: A review. Maturitas. 11. 1989: 259-274
- Menopause-related changes in lipoproteins and some other cardiovascular risk factors.Int J Epidemiol. 1990; 19: 42-48
- Ovarian hormones and the circulation.Maturitas. 1990; 12: 287-298
- Lipoprotein cholesterol distibutions in selected North American populations: The Lipid Research Clinics Program Prevalence Study.Circulation. 1980; 61: 302-315
- Lipids and lipoproteins in women after oophorectomy and the response to estrogen therapy.Br J Obstet Gynaecol. 1983; 90: 171-177
- Short-term effect of oophorectomy on lipoprotein metabolism.Gynecol Obstet Invest. 1984; 18: 134-139
- Differences in low density lipoprotein subfractions and apolipoproteins in premenopausal and postmenopausal women.J Clin Endocrinol Metab. 1988; 67: 30-35
- Menopause and risk factors for coronary heart disease.N Engl J Med. 1989; 321: 641-646
- Effects of bilateral oophorectomy on lipoprotein metabolism.Br J Obstet Gynaecol. 1990; 97: 78-82
- Influence of menopause on serum lipids and lipoproteins.Maturitas. 1990; 12: 321-331
- Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative centrifuge.Clin Chem. 1972; 18: 499-502
- Incidence of coronary heart disease and lipoprotein cholesterol levels: The Framingham Study.J Am Med Assoc. 1986; 256: 2835-2838
- The triglyceride issue: a view from Framingham.Am Heart J. 1986; 112: 432-437
- Arch Intern Med. 1988; 148: 36-69
- Case-control studies. Design, conduct, analysis.Oxford University Press, Oxford1982
- Postmenopausal estrogen cancer and other considerations.Women Health. 1986; 11: 179-195
- Serum cholesterol levels in adults: United States, 1960–1962.in: Vital Health Stat, no 22. US Govt Printing Office, Washington DC1967
- Body cholesterol removal: role of plasma high density lipoproteins.Adv Lipid Res. 1980; 17: 1-51
- Keeping or removing the ovaries at the time of hysterectomy.Eur J Obstet Gynecol Reproduct Biol. 1988; 28: 140-146
- The effect of hysterectomy on the age at ovarian failure: identification of a subgroup of women with a premature loss of ovarian function and literature review.Fertil Steril. 1987; 47: 94-100
- Differential effects of oral estrone versus 17-β estradiol on lipoproteins in postmenopausal women.J Clin Endocrinol Metab. 1990; 70: 1568-1573
Article info
Publication history
Accepted:
December 1,
1993
Received in revised form:
January 11,
1993
Received:
October 9,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
