Research Article| Volume 17, ISSUE 2, P129-137, September 1993

Effects and acceptability of a new 17β-oestradiol-releasing vaginal ring in the treatment of postmenopausal complaints

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      The treatment of postmenopausal symptoms was studied in 26 healthy women using a new synthetic rubber (Kraton D 2109) vaginal ring containing 53 mg of 17β-oestradiol. All women were postmenopausal, at least 6 months after the last vaginal bleeding and suffering from daily hot flushes. The study was conducted in a double-blind placebo-controlled intrapatient cross-over fashion, and the study period was 6 months. The rings used give an initial in vitro release rate of 0.4 mg/E2 per day. The in vitro release rate decreases to about 0.2 mg/day after 20 days and levels off asymptotically to about 0.1 mg/day after 50 days. Serum E2 levels equivalent to the follicular phase of the normal menstrual cycle were measured after 1 month's use, and serum E2 level stayed above postmenopausal levels throughout the study period. FSH was suppressed during use of the E2-releasing vaginal ring, while LH showed no statistically significant suppression in continued use. Postmenopausal complaints were recorded by Visual Analogue Scales (VAS) as judged by both the patient and the examining doctor; all complaints had favourable outcomes during use of the E2-releasing vaginal ring without deterioration of symptoms during use of the placebo ring. No serious side-effects were encountered, and the possibility of managing all postmenopausal complaints with intravaginal oestrogen treatment is discussed.


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        • Ettinger B
        Optimal use of post-menopausal hormone replacement.
        Obstet Gynecol. 1988; 72: 31S-36S
        • Schiff I
        • Tulchinsky D
        • Ryan KJ
        Vaginal absorption of estrone and 17β-estradiol.
        Fertil Steril. 1977; 28: 1063-1066
        • Stumpf PG
        Selecting constant serum estradiol levels achived by vaginal rings.
        Obstet Gynecol. 1986; 67: 91-94
        • Lange R
        • Peppas N
        Jms-Rev Macromol Chem Phys. 1983; C23: 61-126
        • Riggs LA
        • Hermann H
        • Yen SSC
        Absorption of estrogens from vaginal creams.
        N Engl J Med. 1978; 298: 195-199
        • Veldhuis JD
        • Samojlik E
        • Evans WS
        • Rogol AD
        • Ridgeway CE
        • Crowley WF
        • Kolp L
        • Checinska E
        • Kirschner MA
        • Thorner MO
        • Stumpf P
        Endocrine impact of pure estradiol replacement in postmenopausal women: Alterations in anterior pituitary hormone release and circulating sex steroid hormone concentrations.
        Am J Obstet Gynecol. 1986; 155: 334-339
        • Holmgren PÅ
        • Lindskog M
        • von Schoultz B
        Vaginal rings for continuous low-dose release of oestradiol in the treatment of urogenital atrophy.
        Maturitas. 1989; 11: 55-63
        • Mandel FP
        • Geola FL
        • Meldrum DR
        • Lu JHK
        • Eggena P
        • Sambhi MP
        • Hershman JM
        • Judd HL
        Biological effects of various doses of vaginally administered conjucated equine estrogens in post-menopausal women.
        J Clin Endocrinol Metab. 1983; 57: 133-138
        • Sarrel PM
        Estrogen replacement therapy.
        Obstet Gynecol. 1988; 72: 2S-5S
        • Brenner PF
        The menopausal syndrome.
        Obstet Gynecol. 1988; 72: 6S-11S
        • Ravnikar VA
        Compliance with hormone therapy.
        Am J Obstet Gynecol. 1987; 156: 1333-1334
        • Weissberger AJ
        • Ho KKY
        • Lazarus L
        Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-h growth hormone (gh) secretion, insulin-like growth factor I, and gh-binding protein in post-menopausal women.
        J Clin Endocrinol Metab. 1991; 72: 374-381