This paper is only available as a PDF. To read, Please Download here.
A group of 62 peri- and postmenopausal women suffering from vasomotor disturbances and a variety of other symptoms were treated with estradiol valerate and chlormadinone acetate continuously using an adjustable dosage regimen. They obtained complete relief from vasomotor symptoms. The continuation rate was 81% after 1 year. In 18 patients the dose had to be adjusted because of breakthrough bleeding (n = 12), mastodynia (n = 3), and for the prevention of bone loss. In 11/12 patients breakhrough bleeding could be stopped by adjusting the dosage. This regimen seems to offer a more flexible approach to hormone replacement therapy (HRT) in the postmenopause than presently available combined preparations for continuous use.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Maturitas
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Biological effects of various doses of conjugated equine estrogens in postmenopausal women.J Clin Endocrinol Metab. 1980; 51: 620-625
- Das Klimakterium.in: Thieme, Stuttgart1987: 285 (ff.)
- Mortality and obesity: The rationale for age specific height-weight tables.in: Andres R Bierman EL Hazzard WR Principles of Geriatric Medicine. McGraw-Hill, New York1985: 311-318
- Long term and withdrawal effects of two different oestrogen-progestogen combinations on lipid and lipoprotein profiles in postmenopausal women.Maturitas. 1989; 11: 117-128
- Comparison of continuous and sequential oestrogen-progestogen treatment in women with climacteric symptoms.Maturitas. 1989; 11: 75-82
- Evaluation of a continuous oestrogen-progestogen regimen for climacteric complaints.Maturitas. 1982; 4: 95-102
- A novel statistical approach to analysis of bleeding patterns during continuous hormone replacement therapy.Maturitas. 1989; 11: 209-215
- Comparison of two equine oestrogen dydrogesterone regimens in the climacteric.Maturitas. 1989; 10: 133-141
- Effects of estrogens and progestins on biochemistry and morphology of the postmenopausal endometrium.N Engl J Med. 1981; 305: 1599-1605
- The physiological action of progesterone and the pharmacological effects of progestogens — a short review.Postgrad Med J. 1978; 54: 11-24
- Physiopathological aspects of body overweight in the female climacteric.Maturitas. 1983; 5: 153-159
- Effects of postmenopausal oestrogen-progestogen replacement on serum lipids and lipoproteins: a review.Maturitas. 1990; 12: 259-285
Accepted: January 8, 1993
Received in revised form: January 7, 1993
Received: April 4, 1992
© 1993 Published by Elsevier Inc.