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Abstract
A group of 62 peri- and postmenopausal women suffering from vasomotor disturbances
and a variety of other symptoms were treated with estradiol valerate and chlormadinone
acetate continuously using an adjustable dosage regimen. They obtained complete relief
from vasomotor symptoms. The continuation rate was 81% after 1 year. In 18 patients
the dose had to be adjusted because of breakthrough bleeding (n = 12), mastodynia (n = 3), and for the prevention of bone loss. In 11/12 patients breakhrough bleeding
could be stopped by adjusting the dosage. This regimen seems to offer a more flexible
approach to hormone replacement therapy (HRT) in the postmenopause than presently
available combined preparations for continuous use.
Keywords
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Article info
Publication history
Accepted:
January 8,
1993
Received in revised form:
January 7,
1993
Received:
April 4,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
