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Abstract
The aim of this study was to determine the effects on plasma lipids and lipoproteins
of oophorectomy and various hormone replacement therapy (HRT) delivery systems using
low doses of medroxyprogesterone acetate (MPA, 2.5 mg/day). A total of 90 women completed
the l-year follow-up period. Patients were randomly assigned to five groups. The first
(n = 16) received 0.625 mg/day conjugated equine oestrogens (CEE) cyclically, the second
(n = 20) 50 μg/day transdermal oestradiol cyclically and the third (n = 15) 0.625 mg/day CEE continuously. These three groups also received 2.5 mg MPA
sequentially for the last 12 days of HRT administration. The fourth group (n = 20) received 0.625 mg/day CEE and 2.5 mg/day MPA continuously, while the fifth
(n = 19) constituted a treatment-free control group. After oophorectomy patients showed
increases in low-density lipoprotein (LDL), apolipoprotein B and the atherogenic index,
whereas after HRT patients exhibited falls in plasma LDL, apolipoprotein B and the
atherogenic index and increases in high-density lipoprotein (HDL) and apolipoprotein
A1. No significant changes in total cholesterol were observed after surgery or treatment
and decreased levels of triglycerides were detected only in the transdermal treatment
group.
Keywords
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Duenas JL, Navarro J. Sindrome climatérico. Resultados de la terapéutica hormonal sustitutiva. Servicios de información cientifica de Schering España, S.A.
Article info
Publication history
Accepted:
August 31,
1992
Received in revised form:
August 31,
1992
Received:
June 22,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
