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Abstract
The purpose of this study was to determine how oophorectomy and different hormone
replacement therapy (HRT) regimens using low doses of medroxyprogesterone acetate
(MPA, 2.5 mg/day) influence the pituitary-gonadal axis function. Ninety (90) women,
who had had regular menses prior to surgery, completed a I-year follow-up period.
Patients were assigned to 5 groups. The first (n = 16) received 0.625 mg/day conjugated equine oestrogens (CEE) cyclically, the second
(n = 20) 50 μday transdermal oestradiol (E2) cyclically and the third (n = 15) 0.625 mg/day CEE continuously. These 3 groups also received 2.5 mg MPA sequentially
for the last 12 days of HRT administration. The fourth group (n = 20) received 0.625 mg/day CEE and 2.5 mg/day of MPA continuously, while the fifth
(n = 19) constituted a control group. After oophorectomy all patients showed increases
in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, and decreases
in those of E2, oestrone (E1), prolactin (PRL), sex-hormone-binding globulin (SHBG), androstenedione (ΔA4) and testosterone (T). No changes were detected in dehydroepiandrosterone sulphate
(DHEA-S) levels. After HRT, decreases′ in FSH, LH and PRL levels and increases in
those of E2, E1 and SHBG were observed, but no changes were seen in T, ΔA4 or DHEA-S plasma levels. As the differences that were found cannot be attributed
to the presence of ovaries, it is reasonable to assume that they were perhaps due
to the treatment. All these changes, with the exception of a decrease in PRL levels,
are therefore to be expected after HRT.
Keywords
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References
- Estrogens and progestins.in: Hormones. Academic Press, San Diego1987: 515-564
- Neuroendocrinology of reproduction.in: Plenum Press, New York1981: 123-125
- Neuroendocrine control of ovarian function in higher primates.in: Leyendecker G Stock H Wildt L Brain and pituitary peptides II. Karger, Munich1983: 11-30
- Estrogen-progestogen once-a-month injectable contraceptives and serum prolactin.Contraception. 1989; 39: 519-529
- The relation between oral contraceptive use and subsequent development of hyperprolactinemia.Fertil Steril. 1981; 36: 464-467
- The influence of exogenous estrogen on the circadian periodicity of circulating prolactin in women.J Clin Endocrinol Metab. 1975; 40: 886-889
- Prolactin: effects of age, menopausal status and exogenous hormones.Am J Obstet Gynecol. 1982; 143: 225-227
- Estrogenic activities of estradiol enantate and ethinyl-estradiol compared at a clinical level.Arzneim Forsch Drug Res. 1986; 36: 1671-1674
- The effect of estrogen treatment on plasma concentrations of steroid hormones, gonadotropins, prolactin and sex hormonebinding globulin in post-menopausal women.Maturitas. 1985; 7: 129-133
- Comparison of two hormone replacement regimensinfluence on lipo-proteins and bone mineral content.Maturitas. 1990; 12: 127-136
- Hormone replacement therapy and changes on pituitary function.Eur J Obstet Gynecol Reprod Biol. 1992; 43: 59-63
- Endocrine changes associated with the menopause and post-menopausal years.in: Campbell S The management of the menopause and post-menopausal years. 1976: 49-62
- Influence of estrogen-progesterone combinations on gonadotrophin secretion in castrated female rats.Endocrinology. 1975; 97: 771-774
- Circulating estradiol, estrone and gonadotropin levels following the administration of orally active 17β-estradiol in postmenopausal women.J Clin Endocrinol Metab. 1975; 40: 518-521
- Studies on prolactin in man.Rec Prog Horm Res. 1972; 28: 527-531
- Augmentation of prolactin secretion by estrogen in hypogonadal women.J Clin Invest. 1974; 53: 652-655
- Mechanisms of control, peripheral actions and modification by drugs.Horm Res. 1979; 10: 143-172
- Prolactin.N Engl J Med. 1978; 298: 201-207
- Regulation of prolactin synthesis in vitro by estrogenic and antiestrogenic derivates of estradiol and estrone.Endocrinology. 1989; 124: 1717-1726
- Antagonism of estrogen-induced prolactin release by dihydrotestosterone.Biol Reprod. 1989; 40: 1201-1207
- Analysis of the effect of progesterone in vivo on estrogen receptor distribution in the rat anterior pituitary and hypothalamus.Endocrinology. 1983; 113: 15-22
- Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer.Am J Obstet Gynecol. 1974; 118: 793-798
- Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood.J Clin Endocrinol Metab. 1974; 39: 1020-1024
- The hormonal activity of the postmenopausal ovary.J Clin Endocrinol Metab. 1976; 42: 247-253
Article info
Publication history
Accepted:
September 22,
1992
Received in revised form:
September 21,
1992
Received:
August 3,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
