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Abstract
Serum and urine electrolytes, and biochemical indices of bone metabolism and liver
function were measured in 51 post-menopausal women treated with two hormone replacement
therapy regimens for 24 wk. Twenty-six of the women were treated continuously with
conjugated equine oestrogens (0.625 mg/day) and the remainder were treated as above
with the addition of norgestrel (0.15 mg/day) during the last 12 days of each 28-day
cycle.
Both treatment regimens affected electrolytes in a similar manner. The most consistent
effect was a reduction in serum sodium levels and a reduction in urinary sodium/creatinine
ratios. The combined regimen appeared to have a greater effect on sodium reabsorption.
Both regimens decreased all the biochemical indices of bone metabolism measured, viz
serum calcium (corrected for albumin), phosphate and alkaline phosphatase and urinary
calcium/creatinine and hydroxyproline/creatinine ratios. The preparations used decreased
the parameters by similar amounts over the 24 wk indicating that both were equally
effective in reducing bone turnover. The data suggested, however, that the combined
regimen had a more profound effect on bone metabolism during the early phase of treatment.
The two treatment regimens had broadly the same effects on the biochemical indices
of liver function, reducing albumin levels and all the liver enzymes. Judging by these
indices neither regimen had a deleterious effect on liver function.
We conclude that the two hormone replacement regimens have similar effects on the
biochemical indices measured, but there are subtle differences between the two treatments
which merit further research.
Keywords
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References
- Alterations in clinical chemistry measures associated with oral contraceptives and oestrogen use.in: The Lipid Research Clinics Program Prevalence Study. J Reprod Med. 27. 1982: 275-282
- Plasma electrolyte concentrations in women and the effects of oestrogen administration.Maturitas. 1982; 4: 247-256
- The minimum effective dose of estrogen for prevention of postmenopausal bone loss.Obstet Gynecol. 1984; 63: 759-763
- Effects of oestrogen and progestogen therapy on calcium metabolism in post-menopausal women.Front Horm Res. 1975; 3: 150-176
- Effects of progestins on bone metabolism in postmenopausal women.J Reprod Med. 1982; 27: 511-514
- An automated procedure for the quantitative determination of hydroxyproline.Clin Biochem. 1974; 7: 251-257
- The tubular reabsorption of phosphate in man.in: Hisco DJ Phosphate et Metabolisme phosphocalcique. Sandoz, Paris1971: 153-180
- Data analysis in Rummage: A user's guide.Brigham Young University, Utah1980
- The “sodium-retaining effect” of sex hormones.Science. 1937; 86: 40-41
- The effect of conjugated estrogens on the renin-angiotensin system.J Clin Endocrinol Metab. 1977; 44: 1061-1068
- Hypertension, oral contraceptive agents and conjugated estrogens.Ann Intern Med. 1971; 74: 13-21
- The influence of estrogen and progesterone on aldosterone excretion.J Clin Endocrinol. 1962; 22: 161-167
- Patterns of change for various biochemical constituents detected in well population screening.Clin Chim Acta. 1972; 41: 375-387
- Biochemical changes at the menopause: possible role of the central nervous system.Maturitas. 1984; 6: 259-267
- The catabolic and natriuretic effects of progesterone in man.Recent Progr Horm Res. 1961; 17: 249-281
- Metabolic effects in man of steroids with progestational activity.Ann NY Acad Sci. 1958; 71: 588-598
- The effect of estrogen on water and electrolyte metabolism. I. The normal.J Clin Invest. 1956; 35: 423-429
- A randomized double-blind crossover trial into the effect of norethisterone on climacteric symptoms and biochemical profiles.Br J Obstet Gynaecol. 1982; 89: 464-472
- Preventive effect of estrogen on postmenopausal bone loss.Ann Intern Med. 1975; 125: 1439-1442
- Bone remodeling and calcium metabolism.in: A correlated histomorphometric, calcium kinetic and biochemical study in patients with osteoporosis and Paget's disease. Metabolism. 26. 1977: 559-563
- Diagnostic procedures in disorders of calcium metabolism.Metabolism. 1978; 8: 589
- Prevention of bone mineral loss in postmenopausal women by norethisterone.Obstet Gynecol. 1985; 66: 789-792
- Uncoupling of bone formation and resorption by combined oestrogen and progestagen therapy in postmenopausal osteoporosis.Lancet. 1985; ii: 800-801
- Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis.J Clin Endocrinol Metab. 1980; 51: 1359-1364
- Control of renal tubular phosphate reabsorption by parathyroid hormone in man.Clin Sci Mol Med. 1977; 53: 431-438
- Early effects of ethinyloestradiol and norethisterone treatment in post-menopausal women on bone resorption and calcium regulating hormones.Clin Sci. 1985; 69: 265-271
- Effects of a short course of estrogen on mineral metabolism in postmenopausal women.J Clin Endocrinol Metab. 1985; 61: 595-600
- Effect of administration of a combined estrogen-progestin contraceptive on the level of individual plasma proteins.Scand J Clin Lab Invest. 1967; 21: 337-341
- Biological effects of various doses of conjugated equine estrogens in postmenopausal women.J Clin Endocrinol Metab. 1980; 51: 620-625
- Serum protein alterations produced in women by synthetic oestrogens.J Clin Endocrinol. 1967; 27: 1463-1470
- Enzyme induction as a possible cause of increased serum triglycerides after oral contraceptives.Lancet. 1976; i: 1107-1108
- Effects of drugs and environmental chemicals on steroid metabolism.Clin Pharmacol Ther. 1973; 14: 727-741
- Low plasma bilirubin in epileptics on phenobarbitone.Lancet. 1969; i: 21-22
- Plasma enzyme changes and their interpretation in patients receiving anticonvulsant and enzyme inducing drugs.in: Richen A Woodford FP Anticonvulsant drugs and enzyme induction. Elsevier, Amsterdam1969
- The effects of conjugated equine oestrogens with and without a cyclical progestogen on lipoproteins and HDL subfractions in postmenopausal women.Acta Endocrinol. 1986; 113: 123-127
- Synthesis of very low density lipoproteins in the cockerel.in: Effects of estrogen. J Clin Invest. 58. 1976: 368-379
- Menopausal estrogen use, high density lipoprotein subfractions and liver function.Atherosclerosis. 1983; 49: 31-39
- Serum alkaline phosphatase during hormone treatment in early postmenopausal women.Acta Med Scand. 1984; 216: 11-17
- Serum bone GLA-protein.in: A specific marker for bone formation in postmenopausal osteoporosis. Lancet. i. 1984: 1091-1093
- Serum bone gla protein variations during estrogen and calcium prophylaxis of post-menopausal women.Calcif Tissue Int. 1984; 36: 536-540
- Improved method for the quantitative determination of serum alkaline phosphatase of skeletal origin.Clin Chem. 1981; 27: 2002-2007
- Changes in the bone and liver isoenzymes of alkaline phosphatase in postmenopausal women being treated with norethisterone.Clin Chim Acta. 1987; (in press)
Article info
Publication history
Accepted:
October 1,
1987
Received in revised form:
September 25,
1987
Received:
June 23,
1987
Identification
Copyright
© 1988 Published by Elsevier Inc.
