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Abstract
Concentrations of progesterone and oestradiol in peripheral serum and tumour cyst
fluid were measured in 42 post-menopausal women with epithelial ovarian tumours (17
cancer, 6 borderline malignant, 19 benign tumours) and in 19 post-menopausal women
without ovarian neoplasms. The hormonal response of the endometrium was assessed,
progestogen and oestrogen receptor content in the tumour tissue case recorded, and
tumour deoxyribonucleic acid (DNA) ploidy was measured by flow cytometry.
No significant differences were found between the mean serum steroid levels in patients
with malignant, borderline or benign tumours, but the mean serum levels of oestradiol
in patients with malignant or benign ovarian tumours were higher than those in the
controls. Endometrial hormonal activity was seen in 19% of the samples studied. Malignant
and benign mucinous epithelial tumours were the types most frequently associated with
hormonal activity. Increased levels of sex steroids were seen in the cyst fluid of
serous malignant and borderline malignant tumours, while benign tumours were inactive.
The steroid receptor content of the various tumour types did not vary significantly.
Ten (59%) out of 17 ovarian carcinomas were found to be aneuploid and 41% diploid
as measured by flow cytometry. No significant differences in serum levels of progesterone
and oestradiol were found between aneuploid and diploid ovarian carcinomas.
These results contribute to our knowledge of the hormonal activity of epithelial ovarian
tumours in post-menopausal women.
Keywords
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Article info
Publication history
Accepted:
September 17,
1987
Received in revised form:
August 17,
1987
Received:
June 16,
1987
Identification
Copyright
© 1988 Published by Elsevier Inc.
