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Abstract
In order to explore the long-term effect of hormone (17β-oestradiol) substitution
therapy on blood pressure in healthy post-menopausal women, we reviewed the data from
five long-term (1–2 yr), double-blind, placebo-controlled studies carried out in our
department over the last decade. Three of the studies related to early post-menopausal
women (mean age 50 in all three cases) and two involved later post-menopausal women
(mean ages 64 and 70, respectively).
The systolic blood pressure values during hormonal substitution therapy showed no
change in relation to those recorded during placebo administration, whereas the diastolic
blood pressure fell slightly in all five studies. However, in that based on the oldest
subjects, the results were not statistically significant.
It was therefore concluded that hormone substitution therapy with 17β-oestradiol has
no adverse effect on blood pressure, and may even have a beneficial action.
Keywords
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Article info
Publication history
Accepted:
November 30,
1987
Received in revised form:
October 23,
1987
Received:
August 28,
1987
Identification
Copyright
© 1988 Published by Elsevier Inc.
