Research Article| Volume 9, ISSUE 4, P297-302, March 1988

Growth hormone and somatomedin C during post-menopausal replacement therapy with oestrogen alone and in combination with an antioestrogen

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      Serum concentrations of growth hormone (GH) and somatomedin C were monitored in 14 women during post-menopausal replacement therapy with oestrogen alone and in combination with a specific antioestrogen. During 3 mth of treatment with ethinyl oestradiol (10 μg daily), the mean serum GH level rose from 2.8 ± 0.78 mU/l (mean ± S.E.M.) to 6.5 ± 0.39 mU/l, whereas the concentration of somatomedin C fell from 22.4 ± 0.89 to 15.4 ± 0.43 nM. These changes during unopposed oestrogen treatment were clearly reversed by the addition of tamoxifen (20 mg daily), following which GH concentrations fell to pre-treatment levels. It is suggested that oestrogens inhibit somatomedin C production in the liver and that GH secretion may play an important role in regard to certain liver effects induced by oral oestrogen therapy.


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        • Hammond CB
        • Maxson WS
        Current status of estrogen therapy for the menopause.
        Fertil Steril. 1982; 37: 5-25
        • Anderson KE
        • Kappas A
        Hormones and liver function.
        in: Shiff L Shiff ER Diseases of the liver. J.B. Lippincott Company, Philadelphia1982: 167-235
        • Grossman CJ
        Interactions between the gonadal steroids and the immune system.
        Science. 1985; 227: 257-261
        • Eisenfeld AJ
        • Aten RF
        Estrogen receptor in the mammalian liver.
        in: Langer M Chiandussi L Chopra IJ Martini L The endocrines and the liver. Serono Symposia. 51. Academic Press, 1982: 49-62
        • von Schoultz B
        • Damber M-G
        Growth hormone, oestrogens and liver-protein synthesis.
        Maturitas. 1984; 6: 177
        • Duursma SA
        • Bijlsma JWJ
        • van Paassen HC
        • Slootweg MC
        Oestrogens and bone metabolism: a hypothesis.
        Maturitas. 1986; 8: 1-6
        • Mode A
        • Norstedt G
        • Simic B
        • Eneroth P
        • Gustafsson JÅ
        Continuous infusion of growth hormone feminizes hepatic steroid metabolism in the rat.
        Endocrinology. 1981; 102: 2103-2108
        • Jansson JO
        • Edén S
        • Isaksson O
        Sexual dimorphism in the control of growth hormone secretion.
        Endocrinol Rev. 1985; 6: 128-150
        • Jellinck PH
        • Quail J
        • Crowley CA
        Normal and recombinant human growth hormone administered by constant infusion feminize catechol estrogen formation by rat liver microsomes.
        Endocrinology. 1985; 117: 2274-2278
        • Wiedemann E
        • Schwartz E
        • Frantz AG
        Acute and chronic estrogen effects upon serum somatomedin activity, growth hormone and prolactin in man.
        J Clin Endocrinol Metab. 1976; 42: 942-952
        • Copeland KC
        • Johnson DM
        • Kuehl TJ
        • Castrancae WD
        Estrogen stimulates growth hormone and somatomedin C in castrated and intact female baboons.
        J Clin Endocrinol Metab. 1984; 58: 698-703
        • Cuttler L
        • van Vliet G
        • Conte FA
        • Kaplan SL
        • Grumbach MM
        Somatomedin C levels in children and adolescents with gonadal dysgenesis: differences from age matched normal females and effect of chronic estrogen replacement therapy.
        J Clin Endocrinol Metab. 1985; 60: 1087-1092
        • Ottosson U-B
        • Carlström K
        • Johansson BG
        • von Schoultz B
        Effects of an antiestrogen on subfractions of HDL cholesterol during estrogen replacement threapy.
        Gynecol Obstet Invest. 1984; 18: 140-146
        • Schwander J
        • Hauri C
        • Zapf J
        • Froesch ER
        Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: Dependence on growth hormone status.
        Endocrinology. 1983; 113: 297-305
        • Kemp SF
        • Canfield ME
        Acute effects of growth hormone administration: vitamin A and visceral protein concentrations.
        Acta Endocrinol. 1983; 104: 390-396
        • Berelowitz M
        • Szabo M
        • Frohman LA
        • Firestone S
        • Chu L
        • Hentz RL
        Somatomedin C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary.
        Science. 1981; 212: 1279-1281
        • Griffin EE
        • Miller LL
        Effects of hypophysectomy of liver donors on net synthesis of specific plasma proteins by the isolated perfused rat liver.
        J Biol Chem. 1974; 249: 5062-5069
        • Fröhlander N
        • Gidley-Baird AA
        • Hau J
        • von Schoultz B
        Effects of growth hormone on pregnancy associated murine protein-1.
        J Reprod Fertil. 1987; 79: 367-371
        • Rudd BT
        • Rayner PHW
        • Thomas PH
        Observations on the role of GH/IGF-1 and sex hormone binding globulin (SHBG) in the pubertal development of growth hormone deficient (GHD) children.
        Acta Endocrinol (Kbh). 1986; 113: 164-169