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Abstract
Serum concentrations of growth hormone (GH) and somatomedin C were monitored in 14
women during post-menopausal replacement therapy with oestrogen alone and in combination
with a specific antioestrogen. During 3 mth of treatment with ethinyl oestradiol (10
μg daily), the mean serum GH level rose from 2.8 ± 0.78 mU/l (mean ± S.E.M.) to 6.5
± 0.39 mU/l, whereas the concentration of somatomedin C fell from 22.4 ± 0.89 to 15.4
± 0.43 nM. These changes during unopposed oestrogen treatment were clearly reversed
by the addition of tamoxifen (20 mg daily), following which GH concentrations fell
to pre-treatment levels. It is suggested that oestrogens inhibit somatomedin C production
in the liver and that GH secretion may play an important role in regard to certain
liver effects induced by oral oestrogen therapy.
Keywords
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Article info
Publication history
Accepted:
October 28,
1987
Received in revised form:
September 21,
1987
Received:
February 27,
1987
Identification
Copyright
© 1988 Published by Elsevier Inc.
