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Serum concentrations of growth hormone (GH) and somatomedin C were monitored in 14 women during post-menopausal replacement therapy with oestrogen alone and in combination with a specific antioestrogen. During 3 mth of treatment with ethinyl oestradiol (10 μg daily), the mean serum GH level rose from 2.8 ± 0.78 mU/l (mean ± S.E.M.) to 6.5 ± 0.39 mU/l, whereas the concentration of somatomedin C fell from 22.4 ± 0.89 to 15.4 ± 0.43 nM. These changes during unopposed oestrogen treatment were clearly reversed by the addition of tamoxifen (20 mg daily), following which GH concentrations fell to pre-treatment levels. It is suggested that oestrogens inhibit somatomedin C production in the liver and that GH secretion may play an important role in regard to certain liver effects induced by oral oestrogen therapy.
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Accepted: October 28, 1987
Received in revised form: September 21, 1987
Received: February 27, 1987
© 1988 Published by Elsevier Inc.