Research Article| Volume 10, ISSUE 4, P343-352, December 1988

A comparison of the effects of ethinyl estradiol and estradiol valerate on serum and lipoprotein lipids

      This paper is only available as a PDF. To read, Please Download here.


      Serum lipids and lipoproteins were assessed after treatment with 2 mg of oestradiol valerate (E2V) and 10 μg of ethinyl oestreadiol (EE) in a group of 24 oophorectomised women in a study with an open cross-over design.
      E2V in this oral dose was quite inert in its effect on lipoprotein lipids. Ten micrograms of EE is a dose which in most women is sufficient to alleviate post-menopausal vasomotor symptoms. However, this low dose of EE increased serum triglycerides as a result of increased levels in the ultracentrifugally isolated lipoprotein fractions. Increased levels of serum and lipoprotein triglycerides are considered cardiovascular risk factors in women.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Maturitas
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Lipid Research Clinics Program
        The Lipid Research Clinics coronary primary prevention trial results. II.
        in: The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. J Am Med Assoc. 251. 1984: 365-374
        • Silfverstolpe G
        • Gustavsson A
        • Samsioe G
        • Svanborg A
        Lipid metabolic studies in oophorectomized women: effects induced by two different estrogens on serum lipids and lipoproteins.
        Gynecol Obstet Invest. 1980; 11: 161-169
        • Walton KW
        • Scott PI
        • Dykes PW
        • Davies JWL
        The significance of alterations in serum lipids in thyroid dysfunction. II.
        in: Alterations of the metabolism and turnover of 131I-low-density lipoproteins in hypothyroidism and thyrotoxicosis. Clin Sci. 29. 1965: 217-238
        • Wallentin L
        • Larsson-Cohn U
        Metabolic and hormonal effects of postmenopausal oestrogen replacement. II.
        in: Plasma lipids. Acta Endocrinol (Copenh). 1977: 597-607
        • Robinson RW
        • Higano N
        • Cohen W
        Effects of long-term administration of estrogens on serum lipids of postmenopausal women.
        N Engl J Med. 1960; 263: 828-831
        • Tikkanen MJ
        • Kuusi T
        • Vartiainen E
        • Nikkilti EA
        Treatment of post-menopausal hypercholester olaemia with estradiol.
        Acta Obstet Gynecol Scand. 1979; 88: 83-88
        • Aitken JM
        • Lorimer AR
        • McKay Hart D
        • Lawrie TDW
        • Smith DA
        The effects of oophorectomy and long-term mestranol therapy on the serum lipids of middle-aged women.
        Clin Sci. 1971; 41: 597-603
        • Goldzieher JW
        • Chenault CB
        • de la Pena A
        • Dozier TS
        • Kraemer DC
        Comparative studies of the ethinyl estrogens used in oral contraceptives. VII.
        in: Effects with and without progestational agents on ultracentrifugally fractionated plasma lipoproteins in humans, baboons and beagles. Fertil Steril. 30. 1978: 522-533
        • Walter S
        • Jensen HK
        The effect of treatment with oestradiol and oestriol on fasting serum and cholesterol and triglyceride levels in postmenopausal women.
        Br J Obstet Gynecol. 1977; 84: 869-872
        • Enk L
        • Crona N
        • Samsioe G
        • Silfverstolpe G
        Dose and duration effects of estradiol valerate on serum and lipoprotein lipids.
        Horm Metab Res. 1986; 18: 551-554
        • Punnonen R
        • Rauramo L
        Effect of bilateral oophorectomy and peroral estradiol valerate therapy on serum lipids.
        Int J Gynaecol Obstet. 1976; 14: 13-16
        • Bolton CH
        • Ellwood M
        • Hartog M
        • Martin R
        • Rowe AS
        • Wensley RT
        Comparsion of the effects of ethinyl oestradiol and conjugated equine oestrogens in oophorectomized women.
        Clin Endocrinol. 1975; 4: 131-138
        • Miller NE
        • Thelle DS
        • Förde OH
        • Mjǒs OD
        The Tromsö Heart Study.
        in: High density lipoprotein and coronary heart disease. A prospective case-control study. Lancet. 2. 1977: 965-968
        • Gordon T
        • Castelli WP
        • Hjortland MC
        • Kannel WB
        • Dawber TR
        High density lipoprotein as a protective factor against coronary heart disease.
        in: The Framingham Study. Am J Med. 62. 1977: 707-714
        • Carlsson LA
        • Böttiger L-E
        Risk factors for ischaemic heart disease in men and women. 1985; 218: 207-211
        • Lapidus L
        • Bengtsson C
        • Lindqvist O
        • Sigurdsson J
        • Rybo E
        Triglycerides — main lipid risk factor for cardiovascular disease in women?.
        Acta Med Scand. 1985; 217: 481-489
        • Heyden S
        • Heiss G
        • Hames CG
        • Bartel AG
        Fasting triglycerides as predictors of total and CHD mortality in Evans county, Georgia.
        J Chronic Dis. 1980; 33: 275-282
        • Johansson S
        • Bondjers G
        • Fager G
        • Johansson B
        • Olofsson S-O
        • Vedin A
        • Wiklund O
        • Wilhelmsson C
        Serum apolipoprotein and alpha-lipoprotein cholesterol levels in relation to acute myocardial infarction and its established risk factors in women.
        in: Thesis. University of Göteborg, Sweden1983
        • Skrede S
        • Kvarstein B
        Hyperlipidemia in peripheral atherosclerotic arterial disease.
        Acta Chir Scand. 1975; 141: 333-340
        • McGill HC
        • Stern MP
        Sex and atherosclerosis.
        in: Atherosclerosis reviews. 4. Raven Press, New York1979: 157-242
        • Hoover JJ
        • Walden CE
        • Bergelin RO
        • Wahl PW
        • Albers JJ
        • Hazzard WR
        • Knopp RH
        Cholesterol and triglyceride distributions in an adult employee population: The Pacific Northwest Bell Telephone Company Health Survey.
        Lipids. 1980; 15: 895-903
        • Brown DF
        • Daudiss K
        in: Prevalence in a free-living population in Albany. 47. Circulation, New York1973: 558-566
        • Ottosson UB
        • Carlström K
        • Johansson BG
        • von Schoultz B
        Estrogen induction of liver proteins and high-density lipoprotein cholesterol — a comparison between estradiol valerate and ethinyl estradiol.
        Gynecol Obstet Invest. 1986; 22: 198-205
        • Lindberg UB
        • Crona N
        • Stigendal L
        • Teger-Nilsson AC
        • Silverstolpe G
        A comparison between effects of estradiol valerate and low dose ethinyl estradiol on haemostasis parameters.
        Thrombo. Haemostasis. 1988; (accepted)
        • Horseman A
        • Jones M
        • Francis R
        • Nordin C
        The effect of estrogen dose on postmenopausal bone loss.
        N Engl J Med. 1983; 309: 1405-1407