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Abstract
Serum concentrations of 17β-oestradiol (E2), unconjugated oestrone (E1), total oestrone (tE1), progesterone (P), follicle-stimulating hormone (FSH) and sex-hormone-binding globulin
(SHBG) were measured before and after daily intravaginal administration of 250 μg
micronized E2 and 10 mg micronized P for 14 days to 12 post-menopausal and for 1 day only (during
cycle days 5–8) to 11 pre-menopausal women. In the post-menopausal women the levels
of all steroids increased to maximum values on day 1, 8–10 h after administration
and fell thereafter. In the pre-menopausal women the steroid concentrations rose slowly
to a plateau level 10–15 h after administration. Significantly higher absorption of
E2 and E1 (area under the curve increments) was noted in the post-menopausal than in the pre-menopausal
women.
In the post-menopausal women the steroid levels measured on days 7 and 14 corresponded
to those observed in the very early or late luteal phase. Area under the curve increments
were usually smaller on days 7 and 14 than on day 1 and the absorption kinetics altered
to a ‘pre-menopausal’ pattern. FSH levels were significantly reduced as from 12 h
after administration on day 1 and onwards. A slight (10%) but significant increase
in SHBG levels was noted on day 14. It was concluded that the combined E2 and P treatment used in this investigation brings about a physiological response
with only minimal side effects on the liver as judged from changes in SHBG concentrations.
Keywords
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References
- Steroid-sensitive proteins, growth hormone and somatomedin C in prostatic cancer: Effects of parenteral and oral estrogen therapy.Prostate. 1987; 10: 333-338
- Non-oral routes of estrogen administration.Obstet Gynecol N Am. 1987; 14: 269-298
- Vaginal absorption of oestradiol and progesterone.Maturitas. 1984; 6: 359-367
- Efficacy of estradiol vaginal cream in postmenopausal women.Clin Pharmacol Ther. 1979; 26: 502-507
- Endocrinological and clinical investigations in post-menopausal women following administration of vaginal cream containing oestraiol.Maturitas. 1981; 3: 321-327
- Development of a vaginal ring for achieving physiologic levels of 17beta-estradiol in hypoestrogenic women.J Clin Endocrinol Metab. 1982; 54: 208-210
- A clinical evaluation of treatment with estriol vaginal cream versus suppository in postmenopausal women.Acta Obstet Gynecol Scand. 1983; 62: 397-401
- Biological effects of various doses of vaginally administered conjugated equine estrogen in postmenopausal women.J Clin Endocrinol Metab. 1983; 57: 133-139
- Estriol: Absorption after long-term vaginal treatment and gastrointestinal absorption as influenced by a meal.Acta Obstet Gynecol Scand. 1984; 63: 563-567
- Endocrine impact of pure estradiol replacement in postmenopausal women: Alterations in anterior pituitary hormone release and circulating sex steroid hormone concentrations.Am J Obstet Gynecol. 1986; 155: 334-339
- Intravaginal administration of conjugated estrogens in premenopausal and postmenopausal women.Int J Gynaecol Obstet. 1980; 17: 335-339
- Effects of intravaginal oestrogen treatment upon the vaginal absorption of conjugated equine oestrogens.Maturitas. 1982; 4: 277-281
- The treatment of postmenopausal vaginal atrophy with ovestin vaginal cream or suppositories: Clinical, endocrinological and safety aspects.Maturitas. 1980; 2: 275-282
- The absorption of conjugated oestrogen and sodium oestrone sulphate from the vagina.Ann Chir Gynaecol Fenn. 1974; 63: 186-190
- A group-comparative study of effects of Ovestin cream versus Premarin cream in post-menopausal women with vaginal atrophy.Maturitas. 1980; 2: 311-319
- Adrenocortical steroids, bone mineral content and endometrial condition in post-menopausal women.Maturitas. 1982; 4: 113-122
- Intravaginal administration of progesterone: Enhanced absorption after estrogen treatment.Fertil Steril. 1981; 35: 433-437
- Transport of steroid hormones: Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.J Clin Endocrinol Metab. 1981; 53: 58-68
- Comparison of hepatic impact of oral and vaginal administration of ethinyl estradiol.Am J Obstet Gynaecol. 1955; 151: 868-877
- Response of a liver protein, sex hormone binding globulin (SHBG), to modulations of circulating oestradiol.Maturitas. 1984; 6: 195-196
- Oestrogen-related changes in sex hormone binding globulin levels during normal and gonadotrophin-stimulated menstrual cycles.Clin Endocrinol (Oxf.). 1985; 23: 303-312
- Serum sex hormone-binding globulin during puberty in girls and in different types of adolescent menstrual cycles.Acta Endocrinol (Copenh). 1984; 107: 413-419
- Sex hormone-binding globulin changes during the menstrual cycle.J Clin Endocrinol Metab. 1985; 61: 993-996
Article info
Publication history
Accepted:
September 26,
1988
Received in revised form:
May 26,
1988
Received:
March 11,
1988
Identification
Copyright
© 1988 Published by Elsevier Inc.
