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Abstract
Serum concentrations of dehydroepiandrosterone sulphate (DHAS) were determined in
590 healthy women aged 20–87 yr. Simultaneous assays of dehydroepiandrosterone (DHA)
were performed in 417 of the women. DHA and DHAS levels correlated negatively with
age while the DHA/DHAS ratio proved to be unrelated to age. When values for 60 healthy
men in the age range 20–84 yr were compared with those obtained in 60 randomly-selected
healthy women who were exactly age-matched, the DHAS levels were found to be significantly
lower and the DHA/DHAS ratios significantly higher in the women. These results might
be of use in establishing normal clinical ranges for serum DHA, DHAS and the DHA/DHAS
ratio in women.
Keywords
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References
- Adrenocorticosteroids: chemistry, synthesis and disturbances in disease.Clin Endocrinol Metab. 1985; 14: 867-892
- Steroid hormones, ageing and bone.Clin Endocrinol Metab. 1981; 10: 115-139
- Adrenocortical steroids, bone mineral content and endometrial condition in post-menopausal women.Maturitas. 1982; 4: 113-122
- Adrenal steroids in postmenopausal women: relation to obesity and to bone mineral content.Maturitas. 1987; 9: 25-32
- Serum levels of total dehydroepiandrosterone and total estrone in postmenopausal women with special regard to carcinoma of the uterine corpus.Acta Obstet Gynecol Scand. 1979; 58: 179-181
- Peripheral hormone levels and the endometrial condition in postmenopausal women.Acta Obstet Gynecol Scand. 1983; 62: 309-318
- Serum levels of dehydroepiandrosterone sulphate and total estrone in post-menopausal women with special regard to ‘non-endocrine’ ovarian carcinoma.Acta Obstet Gynecol Scand. 1985; 64: 267-268
- Urinary and plasma androgens in benign breast disease.Lancet. 1973; 1: 1076-1079
- Evolution with ageing of four plasma androgens in postmenopausal women.Maturitas. 1980; 2: 171-177
- Age changes and sex differences in serum dehydroepiandrosterone sulfate throughout adulthood.J Clin Endocrinol Metab. 1984; 59: 551-555
- The interrelationship between plasma 5-ene adrenal steroids in normal women.J Steroid Biochem. 1984; 20: 1353-1355
- Aging and adrenal.in: Labrie F Prolux L Endocrinology. Proceedings 7th International Congress of Endocrinology, Quebec, 1–7 July 1984 Excerpta Medica, Amersterdam1984: 905-908
- Sex differences in the twenty-four-hour mean plasma concentrations of dehydroisoandrosterone (DHA) and dehydroiso-androsterone sulfate (DHAS) and the DHA to DHAS ratio in normal adults.J Clin Endocrinol Metab. 1980; 51: 330-333
- Sex differences in the metabolism of dehydroisoandrosterone sulfate.J Clin Endocrinol Metab. 1980; 51: 334-336
- Circulating concentrations of dehydroepiandrosterone and dehydroepiandrosterone sulfate during puberty.J Clin Endocrinol Metab. 1975; 40: 458-461
- Androgen metabolism in the perimenarcheal period.in: Ludwig H Thomsen K Gynecology and obstetrics. Springer Verlag, Berlin, Heidelberg1986: 798-802
- Dehydroepiandrosterone sulfate in plasma: hydrolysis, extraction and radio-immunoassay.Steroids. 1976; 28: 311-323
- Synthesis of new steroid haptens for radioimmunoassay. Part II.in: 15β-carboxyethylmercaptodehydroepiandrosterone bovine serum albumin conjugate. Specific antiserum for solid phase radioimmunoassay of dehydroepiandrosterone. Steroids. 28. 1976: 111-114
- Gas chromatographic — mass spectrometric studies on solvolyzable steroids in human peripheral plasma.Acta Endocrinol (Kbh). 1966; (Suppl): 109
- Δ5-Androstenediol: kinetics of metabolism and binding to plasma proteins in men and women.J Clin Endocrinol Metab. 1976; 43: 1317-1322
- Evidence for an influence of the ovary on circulating dehydroepiandrosterone sulfate levels.J Clin Endocrinol Metab. 1982; 54: 1069-1071
- Plasma androgens and menstrual cycle: pathophysiological correlates from adolescence to menopause.Horm Res. 1983; 18: 84-97
- Pattern of plasma dehydroepiandrosterone sulfate levels in humans from birth to adulthood: evidence for a testicular production.J Clin Endocrinol Metab. 1978; 47: 572-577
- Adrenarche: changing adrenal response to adrenocorticotropin.J Clin Endocrinol Metab. 1981; 52: 1129-1136
- The adrenal androgen stimulating hormone does not exist.Lancet. 1980; II: 454-456
- Clinical disorders of adrenal function and puberty: an assessment of the role of the adrenal cortex in normal and abnormal puberty in man and evidence for an ACTH-like pituitary adrenal androgen stimulating hormone.in: James VHT Serio M Giusti G Martini L The endocrine function of the human adrenal cortex. Academic Press, London, New York1978: 583-612
- Adrenocortical function in old age: Response to acute adrenocorticotropin stimulation.J Clin Endocrinol Metab. 1982; 54: 187-191
- Androgen secretion after 50 in both sexes.Horm Res. 1983; 18: 37-42
- A prospective long-term study in women from pre-menopause to post-menopause: changing profiles of gonadotrophins, oestrogens and androgens.Maturitas. 1986; 8: 297-307
- Orchidectomy or oestrogen treatment in prostatic cancer: effects on serum levels of adrenal androgens and related steroids.Int J Androl. 1987; 10: 581-587
- Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle.J Clin Endocrinol Metab. 1974; 39: 340-346
Article info
Publication history
Accepted:
May 25,
1988
Received in revised form:
May 10,
1988
Received:
February 3,
1988
Identification
Copyright
© 1988 Published by Elsevier Inc.
