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Abstract
We evaluated the gynecologic risks of unopposed, long-term estrogen use in postmenopausal
women. Our medical record review showed that unopposed estrogen users (mean dose,
0.9 mg of conjugated estrogens) had a significantly higher (P < 0.001) incidence of abnormal vaginal bleeding, curettage, hysterectomy, and endometrial
cancer. The ratios of occurrence of these events among users compared with non-users
were 7.8, 4.9, 6.6 and 7.7. The prevalence of hysterectomy reached 28.2% of users
compared with 5.3% of non-users, and endometrial carcinoma developed in 9.9% of users
compared with 1.4% of non-users.
Keywords
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Article info
Publication history
Accepted:
August 1,
1988
Received in revised form:
July 11,
1988
Received:
December 8,
1987
Footnotes
☆Presented in part at the International Symposium on Osteoporosis, Copenhagen, Denmark, June 3–8, 1984.
☆The research was supported by the Community Service Program of Kaiser Foundation Hospitals. The study protocol was approved by the Kaiser Permanente Medical Care Program, Northern California Region, Institutional Review Board.
Identification
Copyright
© 1988 Published by Elsevier Inc.
