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Abstract
The clinical and hormonal effects of long-term, continuous treatment with veralipride,
a benzamide derivative, were investigated in 10 post-menopausal women. The efficacy
of veralipride in relieving hot flushes was confirmed. No significant change was detected
in depressive mood scores. Except for the late appearance of moderate extrapyramidal
side effects in one patient, the clinical tolerance of veralipride was good. As regards
hormonal effects, veralipride, by virtue of its antidopaminergic action, raised prolactin
levels. Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels declined
significantly, while the serum concentration of dehydroepiandrosterone sulphate (DHEAS)
increased. These hormonal changes were persumably secondary to the chronic hyperprolactinaemia.
Keywords
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References
- Etude du véralipride dans le traitement des bouffées de chaleur de la ménopause.Sem Hôp. 1980; 56: 37-38
- Etude du véralipride dans le traitement des bouffées de chaleur de la ménopause.Sem Hôp. 1980; 56: 1465-1467
- Le véralipride dans le traitement des bouffées de chaleur de la ménopause.Rev Fr Gynecol Obstet. 1985; 80: 163-165
- The physiology and measurement of hot flushes.Am J Obstet Gynecol. 1987; 156: 1284-1288
- Postmenopausal hot flushes: a disorder of thermoregulation.Maturitas. 1980; 2: 101-107
- Effect of clonidine on hot flushes in postmenopausal women.Obstet Gynecol. 1982; 60: 583-586
- Propriétés antidopaminergiques centrales comparées du véralipride et du sulpiride.Rev. Fr Gynecol Obstet. 1981; 76: 655-660
- The effect of serum prolactin on plasma adrenal androgens and the production and metabolic clearance rate of dehydroepiandrosterone sulfate in normal and hyperprolactinemic subjects.J Clin Endocrinol Metab. 1986; 62: 202-207
- Hyperprolactinemic anovulatory syndrome.J Clin Endocrinol Metab. 1976; 42: 132-142
- Etude de l'efficacité et de la tolérance clinique et biologique due véralipride administré au long cours.in: A propos de soixante-quatorze observations. Rev Fr Gynecol Obstet. 80. 1985: 171-173
- A roting scale for extrapyromidol side effects.Acta Psychiatr Scand. 1970;
Article info
Publication history
Accepted:
July 13,
1988
Received in revised form:
April 29,
1988
Received:
March 8,
1988
Identification
Copyright
© 1988 Published by Elsevier Inc.
