Research Article| Volume 3, ISSUE 1, P65-71, March 1981

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Plasma oestrone, oestradiol and androstenedione levels in post-menopausal women: Relation to body weight and height

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      To study the relation between body weight and height and the plasma sex-hormone levels we measured the plasma levels of oestrone (E1), oestradiol (E2) and androstenedione (A) in a group of healthy post-menopausal women with a wide range of body weight.
      The sex hormones were measured by radioimmunoassay with highly specific antisera after purification of the plasma extract by column chromatography.
      Our findings show that there is significant positive correlation between the E1 level and body weight as well as A level and, to a lesser extent, between the E1 level and Quetelet index. For E2 there is no correlation with these parameters. There is also a very slight correlation between A level, body weight and Quetelet index.
      Calculation of the partial correlation coefficient shows that E1 correlates to the same degree with body weight and A level, whereas the A level does not correlate with body weight at a fixed value for the E1 level. We conclude that variation in the E1 level depends to the same degree on the variation in body weight as well as the variation in A level.


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        • Thijssen J.H.H.
        • Longcope C.
        Postmenopausal estrogen production.
        in: van Keep P.A. Greenblatt R.B. Albeaux-Fernet M. Consensus on Menopause Research. MTP Press Limited, Lancaster1976: 25-28
        • Grodin J.M.
        • Siiteri P.K.
        • MacDonald P.C.
        Source of estrone production in postmenopausal women.
        J. Clin. Endocrinol. Metab. 1973; 36: 207-214
        • Poortman J.
        • Thijssen J.H.H.
        • Schwarz F.
        Androgen production and conversion to estrogens in healthy post-menopausal women and in selected patients with breast cancer.
        J. Clin. Endocrinol. Metab. 1973; 37: 101-109
        • Schindler A.E.
        • Ebert E.
        • Friedreich E.
        Conversion of androstenedione to estrone by human fat tissue.
        J. Clin. Endocrinol. Metab. 1972; 5: 627-630
        • Longcope C.
        • Pratt J.H.
        • Schneider S.H.
        • Fineberg S.E.
        In vivo studies on the metabolism of estrogens by muscle and adipose tissue of normal males.
        J. Clin. Endocrinol. Metab. 1976; 43: 1134-1145
        • Siiteri P.K.
        • MacDonald P.C.
        Role of extraglandular estrogen in human endocrinology.
        in: Greep R.O. Astwood E.B. Handbook of Physiology. 1973: 615-683 (Washington D.C.)
        • Rizkallah T.H.
        • Tovell H.M.M.
        • Kelly W.G.
        Production of estrone and fractional conversion of circulating androstenedione to estrone in women with endometrial carcinoma.
        J. Clin. Endocrinol. Metab. 1975; 40: 1045-1052
        • Marshall D.H.
        • Fearnly M.
        • Holmes A.
        • Nordin B.E.C.
        The relation between androstenedione and estrone levels in peri- and post-menopausal women.
        in: van Keep P.A. Greenblatt R.B. Albeaux-Fernet M. Consensus on Menopause Research. MTP Press Limited, Lancaster1976: 100-108
        • Marshall D.H.
        • Crilly R.
        • Nordin B.E.C.
        The relation between plasma androstenedione and oestrone levels in untreated and corticosteroid-treated post-menopausal women.
        Clin. Endocrinol. 1978; 9: 407-412
        • Baird D.T.
        • Burger P.E.
        • Hearon-Jones G.D.
        • Scarramuzzi R.J.
        The site of secretion of androstenedione in non-pregnant women.
        J. Endocrinol. 1974; 63: 201-212
        • Morison D.F.
        Multivariate Statistical Methods.
        in: McGraw-Hill, New York1967: 89
        • Rader M.D.
        • Flickinger G.L.
        • de Villa G.O.
        • Mikuta J.J.
        • Mikhail G.
        Plasma estrogens in postmenopausal women.
        Am. J. Obstet. Gynecol. 1973; 116: 1069-1073
        • Judd H.L.
        • Judd G.E.
        • Lucas W.E.
        • Yen S.S.C.
        Endocrine function of the postmenopausal ovary: concentrations of androgens and estrogens in ovarian and peripheral vein blood.
        J. Clin. Endocrinol. Metab. 1974; 39: 1020-1029
        • Judd H.L.
        • Lucas W.E.
        • Yen S.S.C.
        Serum 17β-estradiol and estrone levels in postmenopausal women with and without endometrial cancer.
        J. Clin. Endocrinol. Metab. 1976; 43: 272-278
        • Baird D.T.
        • Guevara A.
        Concentration of unconjugated estrone and estradiol in peripheral plasma in non-pregnant women throughout the menstrual cycle, castrate and postmenopausal women and in men.
        J. Clin. Endocrinol. Metab. 1969; 29: 149-157
        • Abraham G.E.
        • Maroulis G.B.
        Effect of exogenous estrogen on serum pregnenolone, cortisol and androgens in postmenopausal women.
        Obstet. Gynecol. 1975; 45: 271-276
        • Bleau G.
        • Roberts K.D.
        • Chapdelaine A.
        The in vitro and in vivo uptake and metabolism of steroids in human adipose tissue.
        J. Clin. Endocrinol. Metab. 1974; 39: 236-246
        • Vermeulen A.
        • Verdonck L.
        Sex hormone concentrations in postmenopausal women.
        Clinical Endocrinol. 1978; 9: 59-66