Research Article| Volume 3, ISSUE 1, P21-24, March 1981

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Serum bile acids and lipids during treatment of climacteric symptoms with natural oestrogen-progestin combinations

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      Climacteric symptoms of 21 women were treated for 6 mth with sequential combination preparations containing natural oestrogen (oestradiol and oestriol) and norethisterone acetate as progestin. There were no significant changes during the treatment period in the serum alanine aminotransferase activity or concentrations of cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides, cholic acid and deoxycholic acid. The concentration of chenodeoxycholic acid was, however, significantly decreased after 6 mth treatment. It thus appears that the above natural oestrogen-progestin combinations do not have adverse effects on hepatic function and lipid metabolism.


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        • Song C.S.
        • Rifkind A.B.
        • Gillette P.N.
        • Kappas A.
        Hormones and the liver.
        Am. J. Obstet. Gynecol. 1969; 105: 813-847
        • Adlercreutz H.
        • Tenhunen R.
        Some aspects of the interaction between natural and synthetic female sex hormones and the liver.
        Am. J. Med. 1970; 49: 630-648
        • Bergstein N.A.M.
        Clinical efficacy, acceptability and metabolic effects of low dose combined oral contraceptives.
        Acta Obstet. Gynecol. Scand. 1976; : 51-59
        • Larsson-Cohn U.
        Some effects of oral contraceptives on vitamins and on carbohydrate and lipid metabolism.
        Acta Obstet. Gynecol. Scand. 1976; : 5-12
        • Korman M.G.
        • Hoffman A.F.
        • Summerskill W.H.J.
        Assessment of activity of chronic liver disease: serum bile acids compared with conventional tests and histology.
        N. Engl. J. Med. 1974; 290: 1399-1420
        • Greim H.
        Bile acids in hepatobiliary disease.
        in: Nair P.P. Kritchevsky D. The bile acids. Chemistry, physiology and Metabolism, 3: pathophysiology. Plenum Press, New York1976: 153-180
        • Matern S.
        • Gerok W.
        Editorial: Diagnostic value of serum bile acids.
        Acta Hepato—Gastroenterol. (Stuttgart). 1979; 66: 185-189
        • Laatikainen T.
        • Hesso A.
        Determination of serum bile acids by glass capillary gas-liquid chromatography.
        Clin. Chim. Acta. 1975; 64: 63-68
        • Jones D.E.D.
        • Miranda R.
        • Wolfe M.
        • Demers L.M.
        Serum concentration of bile acids in relation to the normal menstrual cycle, the administration of oral contraceptives and pregnancy.
        Am. J. Obstet. Gynecol. 1978; 130: 592-593
        • Donde V.M.
        • Potdar P.D.
        • Joshi U.M.
        • Saxena B.N.
        Serum bile acids in women taking combination contraceptives.
        Contraception. 1979; 20: 579-583
        • Heikkinen J.
        • Mäentausta O.
        • Ylöstalo P.
        • Jänne O.
        Serum bile acid concentrations during normal pregnancy, in itching women and in patients with intrahepatic cholestasis of pregnancy.
        1980 (To be published)
        • Finley P.R.
        • Schifman R.B.
        • Williams R.J.
        • Lichti D.A.
        Cholesterol in high-density lipoprotein.
        in: Use of Mg2+/Dextran sulfate in its enzymatic measurement. Clin. Chem.24. 1978: 931-933
        • Mäentausta O.
        • Jänne O.
        Radioimmunoassay of conjugated cholic acid, chenodeoxycholic acid and deoxycholic acid from human serum with use 125J-labeled ligands.
        Clin. Chem. 1979; 25: 264-268
        • Wallentin L.
        • Larsson-Cohn U.
        Metabolic and hormonal effects of post-menopausal oestrogen replacement treatment. II. Plasma lipids.
        Acta Endocrinol. (Copenhagen). 1977; 86: 597-607
        • Tikkanen M.J.
        • Nikkilä E.A.
        • Vartiainen E.
        Natural oestrogen as an effective treatment for type-II hyperlipoproteinaemia in postmenopausal women.
        Lancet. 1978; 2: 490-491
        • Lageder H.
        Carbohydrate metabolism and hormonal replacement therapy: problems and clinical results.
        Acta Obstet. Gynecol. Scand. 1977; : 57-63
        • Pertsemlidis D.
        • Panveliwalla D.
        • Ahrens Jr., E.H.
        Effects of clofibrate and of an oestrogen-progestin combination on fasting biliary lipids and cholic acid kinetics in man.
        Gastroenterology. 1974; 66: 565-573
        • Bennion L.J.
        • Ginsberg R.L.
        • Garnick M.B.
        • Bennet P.H.
        Effects of oral contraceptives on the gallbladder bile of normal women.
        N. Engl. J. Med. 1976; 294: 189-192
        • Heuman R.
        • Larsson-Cohn U.
        • Hammar M
        • Tiselius H.-G.
        Effects of postmenopausal ethinyl-estradiol treatment on gallbladder bile.
        Maturitas. 1979; 2: 69-72