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Abstract
Five men and 8 women, 60–69 yr of age, and 4 men and 5 women, 17–37 yr of age, volunteered
for this exploration of possible age-related changes in circadian-rhythm (CR) characteristics
of radio-immunoassayable plasma renin (PRA) and aldosterone (PA). Blood was drawn
at 06.00, 08.00, 12.00, 18.00, 20.00 and 24.00 from recumbent subjects on a habitual
sodium intake of 120–140 mEq/ 24 h. Time-qualified data of PRA and PA, fitted by a
24-h cosine curve, were summarized by a population mean-cosinor method. Circadian
characteristics were compared by a multivariate analysis using Hotelling's t2 test.
Rhythmometry reveals in the elderly women a lower mesor (P < 0.001) and amplitude (P = 0.036) of the CR in PRA and a higher mesor and amplitude (P = 0.021 and P = 0.020, respectively) of the PA-CR. The PRA acrophase is delayed (P < 0.001) in the elderly women (04.40 vs. 08.04) while the timing of the PA acrophase
is similar in the age groups of women compared (05.52 vs. 05.20). These differences
found in women were not observed in the smaller groups of men. The seventh decade
of life may be characterized by an internal circadian desynchronization between the
major components of the renin-angiotensin-aldosterone system. A sex-dependent amplification
of the extent of circadian variation in aldosterone may precede a decrease in the
circadian amplitude occurring during the eighth decade of life, as a sign of the adrenopause
in women.
Keywords
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Article info
Publication history
Accepted:
May 5,
1981
Received:
February 23,
1981
Footnotes
☆Supported by: Consiglio Nazionale delle Ricerche (Pos. 118.04 Prot. no. 73404), Italy; National Institute of General Medical Sciences (GM - 13981), National Institute of Occupational Safety and Health (OH - 00631), National Cancer Institute (CA - 14445), USA.
Identification
Copyright
© 1981 Published by Elsevier Inc.
