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Historical perspective| Volume 3, ISSUE 2, P135-144, August 1981

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Effects of conjugated equine oestrogens and oestriol on blood clotting, plasma lipids and endometrial proliferation in post-menopausal women

DOI:https://doi.org/10.1016/0378-5122(81)90005-0
Effects of conjugated equine oestrogens and oestriol on blood clotting, plasma lipids and endometrial proliferation in post-menopausal women
Previous ArticlePharmacokinetics and pharmacodynamic effects of vaginal oestradiol administration from silastic rings in post-menopausal women
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      Abstract

      The effects on blood-clotting factors, plasma lipids and endometrial proliferation of two types of oral oestrogen therapy ((a) cyclical therapy with 0.625 mg/day conjugated equine oestrogens for 3 wk followed by 1 wk without treatment, and (b) continuous therapy with 2 mg/day oestriol) were investigated in a 5-mth study involving 22 post-menopausal women. Assays were performed in order to measure blood-clotting factors (activity of the factor II-VII-X complex, anti-thrombin III, euglobulin lysis time) and plasma lipids (total cholesterol, triglycerides, lipoprotein electrophoresis) before treatment and after 3 and 4 mth of treatment. The only significant change found to have occurred was a decrease in the beta: alpha lipoproteins ratio; this was greater in the group treated with conjugated equine oestrogens, but was also statistically significant in the group treated with oestriol. Endometrial proliferation was investigated indirectly by means of the medroxyprogesterone acetate (MPA) test before treatment and after 5 mth of treatment. The response to MPA at the end of 5 mth of treatment in patients previously unresponsive, showed endometrial proliferation to have occurred during treatment with conjugated equine oestrogens but not during treatment with oestriol.

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      Article info

      Publication history

      Accepted: February 19, 1981
      Received: October 31, 1980

      Identification

      DOI: https://doi.org/10.1016/0378-5122(81)90005-0

      Copyright

      © 1981 Published by Elsevier Inc.

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