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Abstract
Silastic rings releasing approximately 200 μg of 17β -oestradiol per day were inserted
into the vaginas of 4 post-menopausal women for one to three 21-day periods. Plasma
concentrations of oestrone and oestradiol were analysed by radioimmunoassay. The effect
of circulating oestrogens on FSH, LH and sex-hormone binding globulin (SHBG) levels
as well as on the endometrium was studied. During the first 24 h of treatment the
plasma oestradiol levels were higher than the oestrone levels. But during the following
days of the 21-day periods, the levels of the two oestrogens were almost equal, varying
between about 100 and 200 pg/ml plasma, a pattern similar to that seen in fertile
women. The release of oestradiol from the ring gave stable plasma oestrogen levels.
The FSH and LH levels were clearly depressed while the SHBG levels did not change.
Characteristics of oestrogen influence were found in endometrial biopsies. The rings
were well accepted and could be inserted and removed easily by the women. Absorption
of oestradiol from the vagina is good and more complete than after oral administration
allowing lower doses to be used for treatment.
Keywords
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References
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Article info
Publication history
Accepted:
January 23,
1981
Received:
November 20,
1980
Identification
Copyright
© 1981 Published by Elsevier Inc.
