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This preliminary study investigated the possibility of differential effects of the chronic stress of depression and the acute stress of surgery on post-menopausal oestrogen levels.
Depressive illness was associated with significantly lower post-menopausal urinary oestrogen excretion than was found in a control group of normal healthy women. Oestrogen excretion in the latter group had a higher range and mean than values definitive of the post-menopause which are generally accepted in the literature.
There was a trend, which did not reach significance, towards higher urinary oestrogen levels in two surgical groups than in the normal healthy group.
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Accepted: January 20, 1981
Received: September 11, 1980
© 1981 Published by Elsevier Inc.