Review| Volume 1, ISSUE 4, P279-285, June 1979

Bone loss during oestriol therapy in postmenopausal women

      This paper is only available as a PDF. To read, Please Download here.


      In contrast to all other oestrogens examined thus far oestriol hemisuccinate (12 mg/day) did not prevent bone loss in 28 postmenopausal women. The average bone loss, however, was somewhat less than expected from placebo studies, while the bone loss achieved by a group taking 4–6 mg/day was equal to that achieved by previous placebo groups. To be an effective agent for prevention of post-menopausal osteoporosis oestriol would have to be prescribed in daily doses considerably in excess of 12 mg.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Maturitas
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Aitken J.M.
        • Hart D.M.
        • Lindsay R.
        Oestrogen replacement therapy for the prevention of osteoporosis after oophorectomy.
        Br. Med. J. 1973; ii: 515-518
        • Lindsay R.
        • Aitken J.M.
        • Anderson J.B.
        • Hart D.M.
        • MacDonald E.B.
        • Clark A.C.
        Long-term prevention of postmenopausal osteoporosis by oestrogen.
        in: Evidence for an increased bone mass after delayed onset of oestrogen treatment. 3rd ed. Lancet. i. 1976: 1038-1041
        • Lindsay R.
        • Hart D.M.
        • Purdie D.
        • Ferguson M.M.
        • Clark A.C.
        • Kraszewski A.
        Comparative effects of oestrogen and a progestogen on bone loss in postmenopausal women.
        Clin. Sci. Mol. Med. 1978; 54: 193-195
        • Dequeker J.
        • Ferin J.
        Effect of long-term oestrogen therapy on bone remodelling in women with a natural menopause: cross-sectional and longitudinal study.
        in: van Keep P. Consensus on menopause research. MTP Press, Lancaster1976: 124-131
        • Recker R.R.
        • Saville P.D.
        • Heaney R.P.
        Effect of oestrogens and calcium carbonate on bone loss in postmenopausal women.
        Annals Intern. Med. 1977; 87: 649-655
        • Horsman A.
        • Gallagher J.C.
        • Simpson M.
        • Nordin B.E.C.
        Prospective trial of oestrogen and calcium in postmenopausal women.
        Br. Med. J. 1977; ii: 789-792
        • Smith D.C.
        • Prentice R.
        • Thompson D.J.
        • Hermann W.L.
        Association of exogenous oestrogen and endometrial carcinoma.
        New Engl. J. Med. 1975; 293: 1164-1167
        • Zeil H.K.
        • Finkle W.D.
        Increased rise of endometrial carcinoma among users of conjugated oestrogens.
        New Engl. J. Med. 1975; 293: 1167-1170
        • Lindsay R.
        • Hart D.M.
        • Maclean A.
        • Clark A.C.
        • Kraszewski A.
        • Garwood J.
        Bone response to termination of oestrogen treatment.
        Lancet. 1978; i: 1325-1327
        • Tzingounis V.A.
        • Aksu M.F.
        • Greenblatt R.B.
        Estriol in the management of the menopause.
        J. Am. Med. Assoc. 1978; 239: 1638-1641
        • Trudeau D.L.
        • Freier E.F.
        Determination of calcium in urine and serum by atomic absorption spectrophotometry.
        Clin. Chem. 1967; 13: 101-114
        • King E.J.
        • Wooton I.D.P.
        Procedures for plasma microanalysis in medical biochemistry.
        3rd ed. Churchill, London1956
        • Shimmins J.
        • Smith D.A.
        • Aitken J.M.
        • Anderson J.B.
        • Gillespie F.C.
        The accuracy and reproducibility of bone mineral measurements “in vivo” (b) Methods using sealed isotope sources.
        Clin. Radiol. 1972; 23: 47-51
        • Gallagher J.C.
        • Nordin B.E.C.
        Effects of oestrogen and progestogen therapy on calcium metabolism in postmenopausal women.
        Front. Horm. Res. 1975; 3: 150-176
        • Myhre E.
        Endometrial response to different estrogens.
        in: Estrogen therapy: the benefits and risks. Second ed. Frontiers of hormone research. Vol. 5. Karger, Basel1978: 126-144
        • Dequeker J.
        • Muylder
        • Ferin J.
        The effect of long-term Lynestrenol treatment on bone mass in cyclic women.
        Contraception. 1977; 15: 717-723
        • Follingsted A.H.
        Estriol: the forgotten estrogen.
        J. Am. Med. Assoc. 1978; 239: 29
        • Hart D.M.
        • Lindsay R.
        • Purdie D.
        Vascular complications of long-term oestrogen therapy.
        Front. Horm. Res. 1978; 5: 174-191