Review| Volume 1, ISSUE 4, P235-245, June 1979

Pituitary hormonal profile in menopause

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      The hormonal profile of pituitary hormones was studied by measuring serum FSH, LH, TSH, prolactin (PRL) and growth hormone (GH) in a series of postmenopausal women 50–85 yr old who were at least 1 yr postmenopausal.
      In 116 women mean (±SD) plasma FSH and LH were 55.8 ± 22 mU/ml and 25.6 ± 13.62. In 27 women, 1–5 yr after the menopause (M), mean FSH was 56 ± 23.8 and LH 24.7 ± 11 mU/ml and in 22 women, 6–9 yr after M, FSH was 60.3 ± 24.6 mU/ml and LH 27.9 ± 17.2 mU/ml. There was then a gradual, but not statistically significant (n.s.) fall of FSH and LH to 51.6 ± 22.6 and 23.9 ± 9 in 23 women, 20 or more years after M.
      TSH was measured in 75 women and its mean value was 4.3 ± 2.4 μU/ml. Three hypothyroid values (70, 20 and 13.5 μU/ml) were also found. Mean TSH value in 20 women aged 50–54 yr (4 ± 2.7 μU/ml) was not significant compared to other age-groups or to 8 women aged 70–85 yr (4.57 ± 2.5 μU/ml).
      Mean PRL in 62 cases was 0.54 ± 0.20 mU/ml. In 17 other women unexplained increased values (>1 mU/ml) of PRL were found. No significant change of PRL was found with advancing age.
      Mean GH in 32 women was 3.7 ± 2.6 ng/ml. Eight other values were found <1 ng/ml and 3 above 10 ng/ml. The distribution of values in the age-group 50–59 yr (n = 22) did not differ from the age-group 60–85 yr (n = 21).
      It is concluded that the basal concentration of gonadotrophins, after an initial rise, as well as that of the other pituitary hormones remains practically unaltered with advancing age in postmenopausal women.


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        • Albert A.
        • Rendall R.V.
        • Smith R.A.
        • Johnson C.E.
        Urinary excretion of gonado-tropin as a function of age.
        in: Engle E.T. Pincus G. Hormones and the aging process. Academic Press, New York1956: 49-58
        • Azizi F.
        • Vagenakis A.G.
        • Portnay G.J.
        • Ropoport B.
        • Ingbar S.H.
        • Braverman L.E.
        Pituitary thyroid responsiveness to intra-muscular thyrotropin-releasing hormone based on analyses of serum thyroxine, triiodothyronine and thyrotropin concentrations.
        N. Engl. J. Med. 1975; 292: 273-277
        • Batrinos M.L.
        Valeur diagnostique du dosage des gonadotrophines hypophysaires.
        Presse Med. 1959; Vol. 67: 2175-2177
        • Ben-David M.
        • L'Hermite M.
        Prolactin and menopause.
        in: van Keep P.A. Greenblatt R.B. Albeaux-Fernet M. Consensus on menopause research. MTP Press, England1976: 19-24
        • Bourne G.H.
        Aging changes in the endocrines.
        in: Gitman L. Endocrines and aging. Charles C. Thomas Publisher, Springfield, Ill1967: 66-75
        • Chakravarti S.
        • Collins W.P.
        • Forecast S.P.
        • Newton J.R.
        • Oram D.H.
        • Studd J.W.W.
        Hormonal profile after the menopause.
        Br. Med. J. 1976; 2: 784-786
        • Franchimont P.
        Secretion normale et pathologique de la somatotrophine et des gonado-trophines humaines.
        Masson et Cie, Paris1971
        • Ingbar S.H.
        Influence of aging on the human thyroid hormone economy.
        in: Greenblatt R. Geriatric endocrinology. Raven Press, New York1978: 13-31
        • Lauritzen C.
        The hypothalamic anterior pituitary system in the climacteric age period.
        in: van Keep P.A. Lauritzen C. Estrogens in the post-menopause. Karger, Basel1975: 20-29
        • Lemarchand-Beraud T.H.
        • Vannotti A.
        Relationships between thyrotropin level, protein bound iodine and free thyroxine concentration in man under normal physiological conditions.
        Acta Endocrinol. 1969; 60: 315-326
        • Loraine J.A.
        • Bell E.T.
        Hormone assays and their clinical application.
        E. and S. Livingstone Ltd, Edinburgh1976
        • Mahesh V.B.
        Gonadotrophins in the menopause.
        in: van Keep P.A. Greenblatt R.B. Albeaux-Fernet M. Consensus on menopause research. MTP Press, England1976: 11-12
        • Mills T.M.
        • Mahesh V.B.
        Gonadotropin secretion in the menopause.
        in: The menopause, clinics in obstetrics and gynaecology. W.B. Saunders Co. Ltd, London, England1977: 71-84
        • Mills T.M.
        • Mahesh V.B.
        Pituitary function in the aged.
        in: Greenblatt R. Geriatric endocrinology. Raven Press, New York1978: 1-11
        • Rutlin E.
        • Hang E.
        • Torjesen P.A.
        Serum thyrotrophin, prolactin and growth hormone response to TRH during estrogen treatment.
        Acta Endocrinol. 1977; 84: 23-35
        • Seaglia H.
        • Medina M.
        • Pinto F.
        • Ferreira A.L.
        Pituitary LH and FSH secretion and responsiveness in women of old age.
        Acta Endocrinol. 1976; 81: 673-679
        • Sandberg H.
        • Voshimine N.
        • Maeda S.
        • Symons D.
        • Zavidnick J.
        Effects of an oral glucose load on serum immunoreactive, insulin, free fatty acid, growth hormone and blood sugar levels, in young and elderly subjects.
        J. Am. Geriatr. Soc. 1973; 21: 433-439
        • Vekemans M.
        • Robyn C.
        Influence of age on serum prolactin levels in women and men.
        Br. Med. J. 1975; 4: 738-739
        • Verzar F.
        Anterior pituitary function in age.
        in: 3rd ed. The pituitary gland. Vol. 2. Donovan. Butterworths, London1966: 444-459
        • Wide L.
        • Nillius S.J.
        • Gemzell C.
        • Roos P.
        Radio-absorbent assay of follicle-stimulating and luteinizing hormone in serum and urine from men and women.
        Acta Endocrinol. 1973;
        • Yamazi T.
        • Shimamoto K.
        • Ishibashi M.
        • Kosaka K.
        • Orimo H.
        Effect of age and sex on circulating and pituitary prolactin levels in human.
        Acta Endocrinol. 1976; 83: 711-719