Estrogen treatment of postmenopausal vaginal atrophy - a cytological assessment

J. Hustin
J. Hustin
Affiliations
Department of Obstetrics and Gynaecology, University of Liège and Institut de Morphologie pathologique, B 6270 Loverval, Belgium
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G.J.A. Drykoningen
G.J.A. Drykoningen
Affiliations
Medical Services Department, Organon International B. V., Oss, Holland Netherlands
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Abstract

The following is an assessment of the maturation value (MV) based upon cytohormonal smears of postmenopausal or hysterectomized patients:

1.
(1) There is a negative correlation between the MV and the number of postmenopausal years.
2.
(2) There is a positive correlation between MV values higher than 60 and urinary excretion of estrogens.
3.
(3) The MV is ideally suited to demonstrate the beneficial effect of various estrogens on the vaginal mucosa.
4.
(4) Though its action is delayed, and necessitates a threshold dose of 33 μg/kg weight/wk, estriol might be considered as the drug of choice for a beneficial effect on the vaginal mucosa, because of its lack of endometrial action at this dosage.

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Accepted: November 8, 1978

Received: July 20, 1978

☆Presented at the Second International Congress on the Menopause, Jerusalem, Israel, 4–9 June 1978.

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