Research Article| Volume 1, ISSUE 3, P207-213, February 1979

Estrogen treatment of postmenopausal vaginal atrophy - a cytological assessment

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      The following is an assessment of the maturation value (MV) based upon cytohormonal smears of postmenopausal or hysterectomized patients:
      • 1.
        (1) There is a negative correlation between the MV and the number of postmenopausal years.
      • 2.
        (2) There is a positive correlation between MV values higher than 60 and urinary excretion of estrogens.
      • 3.
        (3) The MV is ideally suited to demonstrate the beneficial effect of various estrogens on the vaginal mucosa.
      • 4.
        (4) Though its action is delayed, and necessitates a threshold dose of 33 μg/kg weight/wk, estriol might be considered as the drug of choice for a beneficial effect on the vaginal mucosa, because of its lack of endometrial action at this dosage.


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        Apport de la cytologie hormonale à l'étude du contexte endocrinien de la ménopause normale et pathologique.
        Rev. Fr. Cytol. Clin. 1973; 6: 17-24
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        Cytologic evaluation of the effect of various estrogens given postmenopausally.
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        Further observations on the Kober colour and Ittrich fluorescence reactions in the measurement of oestriol, oestradiol and oestrone.
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        The management of the perimenopausal patient.
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