Research Article| Volume 1, ISSUE 3, P175-181, February 1979

Age at menopause and its relation to osteoporosis

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      As one phase of a comprehensive population study of women, bone density was determined in the third lumbar vertebra by dual photon absorptiometric technique. The method involves the use of two radionuclides, which both emit gamma radiation but with different energies (241 Am with 59.6 keV and 137Cs with 662 keV).
      Women in three age strata were studied: 46, 54 and 62 yr. All women aged 46 were still menstruating, while the age strata 54 and 62 were subdivided into two groups: those who still menstruated or had been postmenopausal for a short time and those who had been postmenopausal for many years. The bone mineral content was higher in premenopausal or recently postmenopausal 54-yr-old women than in women of the same age who had been postmenopausal for a long time (P < 0.01). A similar trend was found for women aged 62 (P < 0.10). The differences could not be explained by differences in other factors studied, such as body weight, body height, smoking habits or physical activity. No significant differences were found when women with similar menopausal status in different age groups were compared.


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        • Albright F.
        • Smith P.H.
        • Richardsson A.M.
        Postmenopausal osteoporosis: its clinical features.
        J. Am. Med. Assoc. 1941; 116: 2465-2474
        • Heany R.P.
        • Whedon G.D.
        Radiocalcium studies of bone formation rate in human metabolic bone disease.
        J. Clin. Endocrinol. 1958; 18: 1246
        • Nordin B.E.C.
        Investigation of bone metabolism with calcium47.
        in: A preliminary report. Proc. Roy. Soc. Med.52. 1959: 351-353
        • Nordin B.E.C.
        Pathogenesis of osteoporosis.
        Lancet. 1961; 1: 1011-1015
        • Frost H.M.
        • Villanuea A.R.
        Human osteoblastic activity. I: A comprehensive method of measurement with some results.
        Henry Ford Hosp. Med. Bull. 1961; 9: 76-86
        • Frost H.M.
        Bone dynamics in osteoporosis and osteomalacia.
        in: C.C. Thomas, Springfield, III., U.S.A1966: 74-85
        • Bengtsson C.
        • Blohmé G.
        • Hallberg L.
        • Hällström T.
        • Isaksson B.
        • Korsan-Bengtsson K.
        • Rybo G.
        • Tibblin E.
        • Tibblin G.
        • Westerberg H.
        The study of women in Gothenburg 1968–1969 - a population study.
        in: General design, purpose and sampling results. Acta Med. Scand.193. 1973: 311-318
        • Bengtsson C.
        • Hallberg L.
        • Hällström T.
        • Hultborn A.
        • Isaksson B.
        • Lennartsson J.
        • Lindquist O.
        • Lindstedt S.
        • Noppa H.
        • Redvall L.
        • Samuelsson S.
        The population study of women in Göteborg 1974–1975 - the second phase of a longitudinal study.
        in: General design, purpose and sampling results. Scand. J. Soc. Med.6. 1978: 49-54
        • Roos B.L.
        • Sköldborn H.
        Dual photon absorptiometry in lumbar vertebrae. I: Theory and method.
        Acta Radiol. 1974; 3: 266-280
        • Roos B.O.
        Dual photon absorptiometry in lumbar vertebrae. II: Precision and reproducibility.
        Acta Radiol. 1975; 3: 291-303
        • Daniell H.W.
        Osteoporosis of the slender smokers.
        in: Vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal cigarette smoking and lack of obesity. Arch. Int. Med.136. 1976: 298-304