Maturitas
Volume 31, Issue 2 , Pages 133-135, 4 January 1999

Leiomyoma of the round ligament in a postmenopausal woman

  • Alexander Lösch

      Affiliations

    • Department of Gynecology and Obstetrics, St. Pölten Hospital, Propst-Führer-Straße 4, A-3100 St. Pölten, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43-2742-3002788; fax: +43-2742-3003327
    • ,
  • Maria Gabriela Haider-Angeler

      Affiliations

    • Department of Gynecology and Obstetrics, St. Pölten Hospital, Propst-Führer-Straße 4, A-3100 St. Pölten, Austria
    • ,
  • Christian Kainz

      Affiliations

    • Department of Gynecology and Obstetrics, University of Vienna, Vienna, Austria
    • ,
  • Gerhard Breitenecker

      Affiliations

    • Gynecopathological Unit, Institute of Pathology, University of Vienna, Vienna, Austria
    • ,
  • Johann Lahodny

      Affiliations

    • Department of Gynecology and Obstetrics, St. Pölten Hospital, Propst-Führer-Straße 4, A-3100 St. Pölten, Austria

Received 24 July 1998; accepted 26 October 1998.

Abstract 

Objective: Leiomyoma of the round ligament of the uterus is a rare condition. We present the first case of a postmenopausal, previously hysterectomised, woman who received combined hormonal replacement therapy and developed a leiomyoma of the right round ligament. Method: In sections of the tumor, immunohistochemical reaction with monoclonal antibodies against smooth muscle actin, desmin, vimentin, estrogen receptor and progesterone receptor was performed. Results: The leiomyoma showed bizarre histologic appearance in absence of mitotic figures and degenerative changes. Leiomyocytes presented a positive immunohistochemical reaction with monoclonal antibodies against smooth muscle actin, desmin vimentin and progesterone receptor in absence of estrogen receptor. Conclusion: Progestin as part of a combined hormonal replacement therapy may play an important role in promoting the development of leiomyoma in hormonal responsive tissue of the round ligament in postmenopausal women.

Keywords: Leiomyoma, Round ligament, Hormonal replacement therapy

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PII: S0378-5122(98)00105-4

Maturitas
Volume 31, Issue 2 , Pages 133-135, 4 January 1999

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