Adipocyte factors, high-sensitive C-reactive protein levels and lipoxidative stress products in overweight postmenopausal women with normal and impaired OGTT

Kassi, E.; Dalamaga, M.; Hroussalas, G.; Kazanis, K.; Merantzi, G.; Zachari, A.; Giamarellos-Bourboulis, E.J.; Dionyssiou-Asteriou, A.

doi:10.1016/j.maturitas.2010.05.004

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Volume 67, Issue 1 , Pages 72-77, September 2010

Adipocyte factors, high-sensitive C-reactive protein levels and lipoxidative stress products in overweight postmenopausal women with normal and impaired OGTT

E. Kassi
- Department of Clinical Biochemistry, Medical School, University of Athens, Greece
- These authors have contributed equally to this work.
M. Dalamaga
- Department of Clinical Biochemistry, Medical School, University of Athens, Greece
- These authors have contributed equally to this work.
G. Hroussalas
- Department of Clinical Biochemistry, Medical School, University of Athens, Greece
K. Kazanis
- Department of Clinical Biochemistry, Medical School, University of Athens, Greece
G. Merantzi
- Laboratory of Biochemistry, Evangelismos General Hospital, Athens, Greece
A. Zachari
- Department of Biological Chemistry, Medical School, University of Athens, Greece
E.J. Giamarellos-Bourboulis
- 4th Department of Internal Medicine, Medical School, University of Athens, Greece
A. Dionyssiou-Asteriou
- Department of Clinical Biochemistry, Medical School, University of Athens, Greece
- Department of Biological Chemistry, Medical School, University of Athens, Greece
- Corresponding author at: 11 Korinthou Str., 14564, Kifisia, Athens, Greece. Tel.: +30 2108077255.

Received 1 March 2010; received in revised form 27 April 2010; accepted 11 May 2010. published online 31 May 2010.

Abstract

Objective

In obese postmenopausal women we assessed leptin and adiponectin, high-sensitive C-reactive protein (hsCRP), serum lipids and lipoxidative stress products: oxidized LDL (oxLDL) and malondialdehyde (MDA), in relation to impaired glucose tolerance (IGT).

Methods

Thirty-eight overweight/obese postmenopausal women were included in the study. Eighteen with normal glucose metabolism (NGT) and twenty with IGT, as it is diagnosed by OGTT. Serum leptin, adiponectin, hsCRP and MDA were measured at time 0 and 120min of OGTT while total-cholesterol, LDL, HDL, triglycerides, oxLDL and anti-oxLDL autoantibodies at time 0. Insulin resistance (HOMA)/sensitivity (QUICKI) indexes were estimated.

Results

In subjects with NGT, hsCRP was positively correlated with fasting leptin and HOMA, while in subjects with IGT negatively with QUICKI. In both groups, hsCRP was positively correlated with fasting insulin, body mass index and waist circumference. Fasting adiponectin was positively associated with HDL in both groups and negatively with triglycerides in subjects with NGT as well as with serum glucose levels at time 120min of OGTT in subjects with IGT. No association was observed between oxLDL and adipokines. A significant positive association was found between oxLDL and HOMA in subjects with IGT. During OGTT there was a significant increase of leptin and MDA levels in both groups.

Conclusions

A relationship exists between obesity, insulin and sub-clinical inflammation. Leptin and lipid peroxidation are linked to hyperglycaemic state while oxLDL might be considered as a predictor of insulin resistance. Adiponectin could exert its antiatherogenic effect through HDL independently of the presence of IGT.

Keywords: Obesity, Menopause, Leptin, Adiponectin, Malondialdehyde, Oxidized LDL