Maturitas
Volume 67, Issue 1 , Pages 15-19, September 2010

Testosterone and coronary artery disease in men

  • Carolyn M. Webb

      Affiliations

    • Cardiovascular Sciences, National Heart & Lung Institute, Imperial College London, London, UK
    • Department of Cardiology, Royal Brompton & Harefield NHS Foundation Trust, London, UK
    • Corresponding Author InformationCorresponding author at: Cardiovascular Sciences, NHLI, Imperial College London, Dovehouse Street, London SW3 6LY, UK. Tel.: +44 20 7351 8860; fax: +44 20 7351 8771.
    • ,
  • Peter Collins

      Affiliations

    • Cardiovascular Sciences, National Heart & Lung Institute, Imperial College London, London, UK
    • Department of Cardiology, Royal Brompton & Harefield NHS Foundation Trust, London, UK
    • IRCCS San Raffaele, Rome, Italy

Received 16 March 2010; received in revised form 29 March 2010; accepted 31 March 2010. published online 20 April 2010.

Abstract 

Coronary artery disease (CAD) is the leading cardiovascular cause of death, and in men, endogenous testosterone concentrations are inversely related to the extent and severity of CAD. Testosterone is known to affect a number of risk factors for CAD and has effects on vascular tone, vasoreactivity and blood flow of blood vessels beyond the reproductive system, indicating that testosterone may be involved in the pathogenesis of CAD. In this review we will present and discuss the actions of endogenous testosterone and testosterone treatment on risk factors for CAD, on the blood vessel wall and blood flow, and on atheroma development and progression, and discuss the potential for testosterone use in men with CAD.

Keywords: Coronary artery disease, Testosterone, Men, Risk factors, Vascular effects, Atherosclerosis

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PII: S0378-5122(10)00138-6

doi:10.1016/j.maturitas.2010.03.029

Maturitas
Volume 67, Issue 1 , Pages 15-19, September 2010

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