Maturitas
Volume 62, Issue 1 , Pages 42-46, 20 January 2009

Morphological modification of female bladder after prolonged use of soy-based diets☆

  • Tatiane da Silva Faria

      Affiliations

    • Urogenital Research Unit-UERJ, Biomedical Center, State University of Rio de Janeiro, Av. 28 de Setembro, 87-fundos-FCM-terreo, 20551-030 Rio de Janeiro, RJ, Brazil
    • ,
  • Lavínia Leal Soares

      Affiliations

    • Laboratory of Experimental Nutrition, Department of Morphology Fluminense, Federal University, Rio de Janeiro, Brazil
    • ,
  • Jorge L. Medeiros Jr.

      Affiliations

    • Urogenital Research Unit-UERJ, Biomedical Center, State University of Rio de Janeiro, Av. 28 de Setembro, 87-fundos-FCM-terreo, 20551-030 Rio de Janeiro, RJ, Brazil
    • ,
  • Gilson T. Boaventura

      Affiliations

    • Laboratory of Experimental Nutrition, Department of Morphology Fluminense, Federal University, Rio de Janeiro, Brazil
    • ,
  • Francisco J.B. Sampaio

      Affiliations

    • Urogenital Research Unit-UERJ, Biomedical Center, State University of Rio de Janeiro, Av. 28 de Setembro, 87-fundos-FCM-terreo, 20551-030 Rio de Janeiro, RJ, Brazil
    • ,
  • Cristiane da Fonte Ramos

      Affiliations

    • Urogenital Research Unit-UERJ, Biomedical Center, State University of Rio de Janeiro, Av. 28 de Setembro, 87-fundos-FCM-terreo, 20551-030 Rio de Janeiro, RJ, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 21 2587 6499; fax: +55 21 2587 6121.

Received 21 January 2008; received in revised form 24 September 2008; accepted 9 October 2008. published online 20 November 2008.

Abstract 

Objectives

The aim of this study was to compare the effects of a prolonged use of organic and transgenic soy upon the lipid profile and the collagen/muscle ratio of the detrusor muscle of the bladder.

Methods

Wistar rats were fed three different diets from weaning until sacrifice (15 months old): control group (CG) casein-based diet; organic soy group (OSG) organic soy-based diet; genetically modified soy group (GMSG) transgenic soy-based diet.

Results

There was no difference in the food consumption or in the diet isoflavone components among the groups. Comparing to CG, both OSG and GMSG groups presented a significant (p<0.05) reduction in the body weight, triglycerides, cholesterol and the smooth muscle of the detrusor and a significant (p<0.05) increase of collagen fibers number of the detrusor muscle.

Conclusions

These findings call into question that, the prolonged use of soy-based diets can be deleterious to the bladder by altering the collagen/muscle ratio what can cause bladder dysfunctions similar with that occurring during menopause.

Keywords: Transgenic soy, Estradiol, Cholesterol, Bladder, Collagen

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☆ This work was supported by grants from the National Council of Scientific and Technological Development (CNPq), Foundation for Research Support of Rio de Janeiro.

PII: S0378-5122(08)00267-3

doi:10.1016/j.maturitas.2008.10.010

Maturitas
Volume 62, Issue 1 , Pages 42-46, 20 January 2009

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