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Maturitas
Volume 60, Issue 3
, Pages 185-201
, July 2008
Could transdermal estradiol
+
progesterone be a safer postmenopausal HRT? A review
References
- Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA. 1998;280:605–613
- Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003;349:523–534
- The Women′s Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women′s Health Initiative Randomized Controlled Trial. JAMA 2004;291:1701–12.
- Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women. Brit Med J. 2007;335:239–250
- Conjugated equine estrogens and coronary heart disease: the Women′s Health Initiative. Arch Intern Med. 2006;166:357–365
- . Controversies about HRT – lessons from monkey models. Maturitas. 2005;51:64–74
- . Hormone replacement therapy and the cardiovascular system. Lessons learned and unanswered questions. J Am Coll Cardiol. 2006;47:1741–1753
- . Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation. J Women′s Health. 2006;15:35–44
- . The applicability of hormonal effects on atherosclerosis in animals to heart disease in postmenopausal women. Sem Reprod Med. 2005;23:149–156
- . Issues to debate on the Women′s Health Initiative (WHI) study. Hormone replacement therapy: an epidemiological dilemma?. Hum Reprod. 2003;18:1992–1999
- . Is the estrogen controversy over? Deconstructing the Women's Health Initiative study: A critical evaluation of the evidence. Ann NY Acad Sci. 2005;1052:43–56
- . A critique of the Women′s Health Initiative hormone therapy study. Fertil Steril. 2005;84:1589–1601
- . Risk of cardiovascular disease in relation to the use of combined postmenopausal hormone therapy: detection bias and resolution of discrepant findings in two Women′s Health Initiative studies. Climacteric. 2006;9:416–420
- Effect of estrogen plus progestin on stroke in postmenopausal women: The Women′s Health Initiative: a randomized trial. JAMA. 2003;289:2673–2684
- . Association between hormone replacement therapy and subsequent stroke: a meta-analysis. Brit Med J. 2005;330:342–345
- Increased risk of stroke in hypertensive women using hormone therapy: analyses based on the Danish Nurse study. Arch Neurol. 2003;60:1379–1384
- . Hormone therapy and cardiovascular disease: a systematic review and meta-analysis. Brit J Obstet Gynaecol. 2006;113:5–14
- Hypertension and its treatment in postmenopausal women: baseline data from the Women′s Health Initiative. Hypertension. 2000;36:780–789
- New evidence regarding hormone replacement therapies is urgently required. Transdermal postmenopausal hormone therapy differs from oral hormone therapy in risks and benefits. Maturitas. 2005;52:1–10
- . Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric. 2005;8(Suppl. 1):3–63
- Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women′s Health Initiative randomized trial. JAMA. 2003;290:1729–1738
- . Hot flashes are associated with increased ambulatory systolic blood pressure. Menopause. 2007;14:308–315
- . Hypertension in women. J Hum Hypertens. 2000;14:691–704
- . Novel mechanisms responsible for postmenopausal hypertension. Hypertension. 2004;43:918–923
- . Flow-mediated vasodilation and the risk of developing hypertension in healthy postmenopausal women. J Am Coll Cardiol. 2004;44:1636–1640
- . Augmented sympathetic vasoconstriction in exercising forearms of postmenopausal women is reversed by oestrogen therapy. J Physiol (Lond). 2004;561:893–901
- Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, crossover study. J Clin Endocrinol Metab. 2007;92:2074–2079
- Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen. Contraception. 2007;75:430–437
- . Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women. Circulation. 1997;95:39–45
- . The long-term effect of oral and percutaneous estradiol on plasma renin substrate and blood pressure. Circulation. 1987;4:753–758
- . Estradiol induces discordant angiotensin and blood pressure responses to orthostasis in healthy postmenopausal women. Hypertension. 2005;45:399–405
- . Different effects of transdermal and oral hormone replacement therapy on the renin-angiotensin system, plasma bradykinin level, and blood pressure of normotensive postmenopausal women. Am J Hypertens. 2006;19:744–749
- . Hormone replacement therapy and longitudinal changes in blood pressure in postmenopausal women. Ann Intern Med. 2001;135:229–238
- . Estrogen and hypertension. Curr Hypertension Reports. 2006;8:368–376
- Unopposed estradiol therapy in postmenopausal women: results from two randomized trials. Obstet Gynecol. 2007;109:581–587
- . Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal women. Circulation. 2001;103:2903–2908
- . Differing responses in blood pressure over 24
h in normotensive women receiving oral or transdermal estrogen replacement therapy. Obstet Gynecol. 1997;89:97–103 - . Estradiol with or without progesterone and ambulatory blood pressure in postmenopausal women. Hypertension. 1999;33:1190–1194
- Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology. 2004;145:5745–5756
- . Combined hormone replacement therapy does not protect women against the age-related decline in endothelium-dependent vasomotor function. Circulation. 1998;97:1234–1238
- . Relationships between endogenous sex hormone concentrations and vascular function in postmenopausal women. J Clin Endocrinol Metab. 2007;92:4738–4741
- Natural progesterone and antihypertensive action. Brit Med J. 1986;290:33–34
- One year follow-up of hormone replacement therapy with percutaneous estradiol and low-dose vaginal natural progesterone in women with mild to moderate hypertension. Exp Clin Endocrinol Diabetes. 2003;111:267–273
- . Acute and chronic effects of hormone replacement therapy on the cardiovascular system in healthy postmenopausal women. J Clin Endocrinol Metab. 2004;89:1618–1629
- The Writing Group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA 1995;273:199–208.
- Long-term safety of drospirenone-estradiol for hormone therapy: a randomized, double-blind, multicenter trial. Menopause. 2005;12:716–727
- . Additive effect of drospirenone/17-beta-estradiol in hypertensive postmenopausal women receiving enalapril. Am J Hypertens. 2002;15:816–822
- . Randomized placebo-controlled trial of the effects of drospirenone-estradiol on blood pressure and potassium balance in hypertensive postmenopausal women receiving hydrochlorothiazide. Menopause. 2007;14:408–414
- . Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study. Br Med J. 2007;335:432-
- . Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women.. Diab Obes Metab. 2006;8:538–554
- . Metabolic and vascular effects of progestins in post-menopausal women. Implications for cardioprotection. Maturitas. 2003;46S:S17–S29
- . Effects of estradiol and norethisterone on lipids, insulin resistance and carotid flow. Maturitas. 2008;59:249–258
- Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial. Diabetologia. 2004;47:1175–1187
- Effects of low-dose continuous combined hormone replacement therapy on glucose homeostasis and markers of cardiovascular risk in women with type 2 diabetes. Clin Endocrinol. 2007;66:27–34
- . Effects of short-term transdermal hormone replacement therapy on glycaemic control, lipid metabolism. C-reactive protein and proteinuria in postmenopausal women with type 2 diabetes or hypertension. Hum Reprod. 2003;18:866–870
- . A comparison of oral and transdermal short-term estrogen therapy in postmenopausal women with metabolic syndrome. Fertil Steril. 2006;86:1669–1675
- Noncardiovascular disease outcomes during 6.8 years of hormone therapy: heart and estrogen/progestin replacement study follow-up (HERS II). JAMA. 2002;288:58–64
- . Pharmacological profile of progestins. Maturitas. 2004;47:277–283
- . Progestogens in hormonal replacement therapy: new molecules, risks, and benefits. Menopause. 2002;9:6–15
- . What does minor elevation of C-reactive protein signify?. Am J Med. 2006;119:166.e17–e28
- . A cross-sectional study of the effects of hormone replacement therapy on the cardiovascular disease risk profile in healthy postmenopausal women. Fertil Steril. 2002;77:945–951
- Effect of transdermal estradiol and oral conjugated estrogen on C-reactive protein in retinoid-placebo trial in healthy women. Circulation. 2002;106:1224–1228
- Effects of hormone replacement therapy on C-reactive protein levels in healthy postmenopausal women: comparison between oral and transdermal administration of estrogen. Am J Med. 2002;113:331–334
- . Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women. J Am Coll Cardiol. 2003;41:1358–1363
- . Effects of hormone therapy on C-reactive protein and IL-6 in postmenopausal women: a review article. Climacteric. 2005;8:317–326
- Progestins affect mechanism of estrogen-induced C-reactive protein stimulation. Am J Med. 2006;119:167.e1–e8
- Effect of postmenopausal hormones on inflammation-sensitive proteins. The postmenopausal estrogen/progestin interventions (PEPI) study. Circulation. 1999;100:717–722
- . Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review. Fertil Steril. 2008;90:642–672
- Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women′s Health Initiative observational study. JAMA. 2002;288:980–987
- Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women. Hum Reprod. 2006;21:2715–2720
- . Different effects of oral conjugated equine estrogen and transdermal estrogen replacement therapy on size and oxidative susceptibility of low-density lipoprotein particles in postmenopausal women. Circulation. 2002;106:1771–1776
- Effects of oestradiol and oestroprogestin on erythrocyte antioxidative enzyme system activity in postmenopausal women. Clin Endocrinol. 2006;64:463–468
- . Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA. 2007;298:309–316
- . Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298:299–308
- . Importance of estrogen receptors in hepatic LDL receptor regulation. Arterioscler Thromb Vasc Biol. 1997;17:1800–1805
- . Estrogen activates the high-density lipoprotein receptor gene via binding to estrogen response elements and interaction with sterol regulatory element binding protein-1A. Endocrinology. 2002;143:2155–2168
- . Two antiatherogenic effects of progesterone on human macrophages; inhibition of cholesteryl ester synthesis and block of its enhancement by glucocorticoids. J Clin Endocrinol Metab. 1999;84:265–271
- . Atherosclerosis – an inflammatory disease. N Engl J Med. 1999;340:115–126
- Effects of dydrogesterone and of its stable metabolite, 20-alpha-dihydrodydrogesterone, on nitric oxide synthesis in human endothelial cells. Fertil Steril. 2006;86:1235–1242
- Activation of nitric oxide synthesis in human endothelial cells using nomegestrol acetate. Obstet Gynecol. 2006;108:969–978
- Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors. Hum Reprod. 2007;22:2325–2334
- Effects of transdermal estrogens on endothelial function in postmenopausal women with coronary disease. Climacteric. 2003;6:38–44
- . Estradiol and progestins differentially modulate leukocyte infiltration after vascular injury. Circulation. 2004;109:234–241
- Progesterone, but not medroxyprogesterone, inhibits vascular cell adhesion molecule-1 expression in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2001;21:243–248
- . In vitro effects of progesterone and progestins on vascular cells. Steroids. 2003;68:831–836
- . Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm. Nat Med. 1997;3:324–327
- . Conjugated equine estrogens alone, but not in combination with medroxyprogesterone acetate, inhibit aortic connective tissue remodeling after plasma lipid lowering in female monkeys. Arterioscler Thromb Vasc Biol. 1998;18:1164–1171
- Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone. Arterioscler Thromb Vasc Biol. 1990;10:1051–1057
- . Estrogens, progestins, and atherosclerosis. Arterioscler Thromb Vasc Biol. 2004;24:e190–e191
- Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women. J Am Coll Cardiol. 2000;36:2154–2159
- Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women. Circulation. 1998;98:1158–1163
- . Effect of medroxyprogesterone acetate on endothelium-dependent vasodilation in postmenopausal women receiving estrogen. Circulation. 2001;104:1773–1778
- . Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women. J Clin Endocrinol Metab. 2000;85:4663–4670
- . The effect of hormone replacement therapy on arterial blood pressure and vascular compliance in postmenopausal women with arterial hypertension. J Hum Hypertens. 2002;16:509–516
- Different effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers in postmenopausal women. Atherosclerosis. 2006;189:436–442
- . Progesterone regulation of vascular thromboxane A2 receptors in rhesus monkeys. Am J Physiol Heart Circ Physiol. 2001;281:H1498–H1507
- Ovarian steroid protection against coronary artery hyperreactivity in rhesus monkeys. J Clin Endocrinol Metab. 1998;83:649–659
- . In vitro modulation of primate coronary vascular muscle cell reactivity by ovarian steroid hormones. FASEB J. 1998;12:1419–1429
- . Estrogen effects on arteries vary with stage of reproductive life and extent of subclinical atherosclerosis progression. Menopause. 2007;14:373–384
- Effects of hormone replacement therapy type and route of administration on plasma matrix metalloproteinases and their tissue inhibitors in postmenopausal women. J Clin Endocrinol Metab. 2006;91:3123–3130
- . Hormone replacement therapy use is associated with a lower occurrence of carotid atherosclerotic plaques but not with intima-media thickness progression among postmenopausal women. The vascular aging (EVA) study. Atherosclerosis. 2003;166:163–170
- . Hormonal therapy: does it increase or decrease cardiovascular risk?. Obstet Gynecol Survey. 2006;61:673–681
- . Coronary heart disease events associated with hormone therapy in younger and older women. A meta-analysis. J Gen Intern Med. 2006;21:363–366
- Combined analysis of Women′s Health Initiative observational and clinical trial data on postmenopausal hormone treatment and cardiovascular disease. Am J Epidemiol. 2006;163:589–599
- Estrogen in the prevention of atherosclerosis: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2001;135:939–953
- Estrogen therapy and coronary-artery calcification. N Engl J Med. 2007;356:2591–2602
- Coronary artery calcium scores and risk for cardiovascular events in women classified as “low risk” based on Framingham risk score: the multi-ethnic study of atherosclerosis (MESA). Arch Intern Med. 2007;167:2437–2442
- Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358:1336–1345
- . Postmenopausal hormone therapy: critical reappraisal and a unified hypothesis. Fertil Steril. 2005;83:558–566
- . Timing is everything. Gynecol Endocrinol. 2007;23:1–4
- . Incidence of venous thromboembolism: a community-based study in western France. Thromb Haemost. 2000;83:657–660
- . Postmenopausal estrogen replacement and risk for venous thromboembolism: a systematic review and meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2002;136:680–690
- Estrogen plus progestin and risk of venous thrombosis. JAMA. 2004;292:1573–1580
- . Effects of oral and transdermal estrogen/progesterone regimens on blood coagulation and fibrinolysis in postmenopausal women. A randomized controlled trial. Arterioscler Thromb Vasc Biol. 1997;17:3071–3078
- Effects of conventional or lower doses of hormone replacement therapy in postmenopausal women. Arterioscler Thromb Vasc Biol. 2004;24:1516–1521
- . Hormone replacement therapy and acquired resistance to activated protein C: results of a randomized, double-blind, placebo-controlled trial. Br J Haematol. 2001;115:415–420
- Differential effects of oral and transdermal estrogen/progesterone regimens on sensitivity to activated protein C among postmenopausal women: a randomized trial. Arterioscler Thromb Vasc Biol. 2003;23:1671–1676
- . Transdermal estradiol does not impair hemostatic biomarkers in postmenopausal women. Maturitas. 2005;50:39–43
- . Plu-Bureau G, on behalf of the EStrogen and THromboEmbolism Risk (ESTHER) Study Group. Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk. Lancet. 2003;362:428–432
- Obesity and risk of venous thromboembolism among postmenopausal women: differential impact of hormone therapy by route of estrogen administration. The ESTHER study. J Thromb Haemost. 2006;4:1259–1265
- Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration. The ESTHER study. Circulation. 2005;112:3495–3500
- . Further results on the risk of nonfatal venous thromboembolism in users of the contraceptive transdermal patch compared to users of contraceptives containing norgetimate and 35 mcg of ethinyl estradiol. Contraception. 2007;76:4–7
- . Antiandrogenic progestins for treatment of signs of androgenisation and hormonal contraception. Eur J Obstet Gynecol Reprod Biol. 2004;112:136–141
- The effects of postmenopausal hormone replacement therapy on hemostatic variables: a meta-analysis of 46 studies. Gynecol Endocrinol. 2002;16:335–346
- . Oral contraceptives and venous thromboembolism: a five-year national case-control study. Contraception. 2002;65:187–196
- Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens. Hum Reprod. 2005;20:563–568
- Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control study. J Throromb Haemost. 2005;3:943–948
- Writing Group for the Women′s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 2002;288:321–33.
- Venous thrombosis and conjugated equine estrogen in women with a uterus. Arch Intern Med. 2006;166:772–780
- Hormone therapy and venous thromboembolism among postmenopausal women: Impact of the route of estrogen administration and progestogens: the ESTHER Study. Circulation. 2007;115:840–845
- . Cathecholaminergic modulation of corticotropin-releasing factor and adrenocorticotropin secretion. Endocr Rev. 1989;10:437–458
- . Estrogen regulation of noradrenergic signaling in the hypothalamus. Psychoneuroendocrinology. 1994;19:603–610
- . 5-hydroxytryptamine-mediated behaviour in male and female rats. Neuropharmacology. 1986;25:771–776
- . influence of progesterone on serotonin metabolism: a possible causal factor for mood changes. Psychoneuroendocrinology. 1977;2:257–266
- . Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain. Brain Res. 1975;86:293–306
- . The oestrous cycle and monoamine activity. Br J Pharmacol. 1973;48:600–608
- . Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res. 1996;735:101–107
- Progesterone, progestagens and the central nervous system. Hum Reprod. 2000;15(Suppl. 1):14–27
- . The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion. J Steroid Biochem Mol Biol. 1997;62:299–306
- . Expression of CYP19 (aromatase) mRNA in different areas of the human brain. J Steroid Biochem Mol Biol. 1999;70:237–241
- . Neurosteroids: a new function in the brain. Biol Cell. 1991;71:3–10
- . Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Progr Horm Res. 1997;52:1–32
- . Regulation of high affinity GABAA receptors in the dorsal hippocampus by estradiol and progesterone. Brain Res. 1989;487:178–184
- . Anxiolytic effect of progesterone is mediated by the neurosteroid allopreganolone and GABAA receptor function. Pharmacol Biochem Behav. 1993;45:423–428
- . Anxiolytic effect of progesterone is mediated by the neurosteroid allopreganolone at brain GABAA receptors. J Neuroendocrinol. 1995;7:171–177
- . The neurosteroids, progesterone and 3alpha, 5alpha-THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Res. 1998;808:72–83
- Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma and steroidogenic glands of male and female rats. Endocrinology. 1999;133:1003–1009
- Progesterone and medroxyprogesterone acetate effects on central and peripheral allopregnanolone and beta-endorphin levels. Neuroendocrinology. 2006;24:348–359
- Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Prog Neurobiol. 2003;71:3–29
- . Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. Spine. 1999;24:2134–2138
- Progesterone protection in the wobbler mouse, a genetic model of spinal cord motor disease. Neurobiol Dis. 2002;11:457–468
- . Survival of motoneurons following axotomy is enhanced by lactation or by progesterone treatment. Brain Res. 1989;491:379–382
- . Brain damage, sex hormones and recovery: a new role for progesterone and estrogen?. Trends Neurosci. 2001;24:386–391
- . Progesterone rapidly decreases brain edema: treatment delayed up to 24h is still effective. Exp Neurol. 1996;138:246–251
- . Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats. Exp Neurol. 1994;129:64–69
- . Impact of progestins on estrogen-induced neuroprotection: Synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology. 2002;143:205–212
- . Structural changes in the normally aging cerebral cortex of primates. Prog Brain Res. 2002;136:455–465
- Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum. J Neurochem. 2003;86:848–859
- Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache county study. JAMA. 2002;288:2123–2129
- . Production and actions of estrogens. N Engl J Med. 2002;346:340–352
- . Breast cancer: critical data analysis concludes that estrogens are not the cause, however lifestyle changes can alter risk rapidly. J Clin Epidemiol. 2004;57:766–772
- . Menopause. 2007;14:1060–1068
- . Proliferation of breast epithelial cells in healthy women during the menstrual cycle. Am J Obstet Gynecol. 1997;176:123–128
- Breast cell proliferation in postmenopausal women during HRT evaluated through fine needle aspiration cytology. Breast Cancer Res Treat. 2003;78:159–165
- Estradiol and progesterone regulate the proliferation of human breast epithelial cells. Fertil Steril. 1998;69:963–969
- . Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. Fertil Steril. 1995;63:785–791
- . Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast. J Clin Endocrinol Metab. 1999;84:4559–4565
- Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo. The Breast. 2003;12:142–149
- . Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys. Breast Cancer Res Treat. 2007;101:125–134
- . Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model. Menopause. 2007;14:639–647
- . The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells. Horm Metab Res. 2003;35:76–80
- . Differential effects of progestogens on breast cancer cell lines. Maturitas. 2003;46S1:S55–S58
- . Dose-dependent changes of the ratio of apoptosis to proliferation by norethisterone and medroxyprogesterone acetate in human breast epithelial cells. Horm Metab Res. 2005;37:468–473
- . Differential effects of progestins on breast tissue enzymes. Maturitas. 2003;46(Suppl. 1):S45–54
- . Progestins and their effects on the breast. Maturitas. 2003;46(Suppl. 1):S59–S69
- Differential effects of progestogens, by type and regimen, on estrogen-metabolizing enzymes in human breast cancer cells. Maturitas. 2007;56:142–152
- . The role of progesterone metabolites in breast cancer: potential for new diagnostics and therapeutics. J Steroid Biochem Mol Biol. 2005;93:201–208
- Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women′s Health Initiative randomized trial. JAMA. 2003;289:3243–3253
- Prior hormone therapy and breast cancer risk in the Women′s Health Initiative randomized trial of estrogen plus progestin. Maturitas. 2006;55:103–115
- . A critique of Women′s Health Initiative studies (2002–2006). Nucl Recept Signal. 2006;4:e023
- The decrease in breast-cancer incidence in 2003 in the Unites States. New Engl J Med. 2007;356:1670–1674
- . Breast cancer trends: a marriage between clinical trial evidence and epidemiology. J Natl Cancer Inst. 2007;99:1139–1141
- . Hormone replacement therapy and breast cancer: a qualitative review. Obstet Gynecol. 2001;98:498–508
- Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer. Lancet 1997;350:1047–59.
- . Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin. J Natl Cancer Inst. 2000;92:328–332
- . Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk. JAMA. 2000;283:485–491
- Relationship between long durations and different regimens of hormone therapy and risk of breast cancer. JAMA. 2003;289:3254–3263
- Unopposed estrogen therapy and the risk of invasive breast cancer. Arch Intern Med. 2006;166:1027–1032
- Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy. JAMA. 2006;295:1647–1657
- . Adult weight change and risk of postmenopausal breast cancer. JAMA. 2006;296:193–201
- . The estrogen paradox. Nat Clin Pract Endocrinol Metab. 2007;3:496–497
- Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17{beta}-estradiol. J Natl Cancer Inst. 2001;93:1714–1723
- . Current evidence about the effect of hormone replacement therapy on the incidence of major conditions in postmenopausal women. Brit J Obstet Gynecol. 2005;112:692–695
- . Estrogen affects post-menopausal women differently than estrogen plus progestin replacement therapy. Hum Reprod. 2007;22:1769–1777
- . Postmenopausal hormone therapy and breast cancer: what is the problem?. Maturitas. 2005;51:75–82
- . Breast cancer risk in postmenopausal women using estrogen-only therapy. Obstet Gynecol. 2006;108:1354–1360
- . Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. Int J Cancer. 2005;114:448–454
- . Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study. Breast Cancer Res Treat. 2008;107:103–111
- Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003;362:419–27.
- . Hormone replacement therapy use and variations in the risk of breast cancer. Br J Obstet Gynaecol. 2008;115:169–175
- . Breast cancer: are estrogen metabolites carcinogenic?. Climacteric. 2007;10(Suppl. 2):62–65
- Mammographic densities and risk of breast cancer among subjects with a family history of this disease. J Natl Cancer Inst. 1999;91:1404–1408
- Mammographic density changes during different postmenopausal hormone replacement therapies. Fertil Steril. 2001;76:445–450
- . Postmenopausal hormone therapy and change in mammographic density. J Natl Cancer Inst. 2003;95:30–37
- Combined hormone replacement therapy and risk of breast cancer in a French cohort study of 3175 women. Climacteric. 2002;5:332–340
- . Groupe MISSION. Méthodologie de l’enquête MISSION (Ménopause, rISque de cancer du sein, mOrbidité et prévaleNce). J Gynecol Obstet Biol Reprod. 2005;34:658–665
- . Breast cancer in postmenopausal women with and without hormone replacement therapy: Preliminary results of the MISSION study. Gynecol Endocrinol. 2006;22:423–431
- . Progestins and progesterone in hormone replacement therapy and the risk of breast cancer. J Steroid Biochem Mol Biol. 2005;96:95–108
- . Pregnancy, progesterone and progestins in relation to breast cancer risk. J Steroid Biochem Mol Biol. 2005;97:441–450
- . Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women: results from a randomized placebo-controlled study. Clin Endocrinol. 2007;66:626–631
- Effect of oestrogen during menopause on risk and age at onset of Alzheimer′s disease. Lancet. 1996;348:429–432
- . The relative contributions of menopause and aging to postmenopausal reduction in intervertebral disk height. Climacteric. 2007;10:298–305
- . Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials. JAMA. 2001;285:2891–2897
- . Early postmenopausal hormone therapy improves postural balance. Menopause. 2007;14:14–19
- . Severity of cardiovascular disease in women: relation with exposure to endogenous estrogen. Maturitas. 2006;55:51–57
- . Genome and hormones: Gender differences in physiology: Invited review: cardiovascular protective effects of 17{beta}-estradiol metabolites. J Appl Physiol. 2001;91:1868–1883
- . Estrogen metabolites and systolic blood pressure in a population-based sample of postmenopausal women. J Clin Endocrinol Metab. 2006;91:1015–1020
- . Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy. Arch Intern Med. 2008;168:861–866
- KEEPS: the Kronos Early Estrogen Prevention Study. Climacteric. 2005;8:3–12
- . Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism. Proc Soc Exp Biol Med. 1998;217:6–16
- . Recent insights into the varying activity of estrogens. Maturitas. 2000;34S:S25–S33
- The Writing Group for the PEPI Trial. Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The postmenopausal estrogen/progestin interventions (PEPI) trial. JAMA 1996;275:370–5.
- Randomized, double-blind, dose-ranging study of the endometrial effects of a vaginal progesterone gel in estrogen-treated postmenopausal women. Am J Obstet Gynecol. 1997;177:937–941
- Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system. Endocr Rev. 2007;28:387–439
☆ Parts of this work were presented separately by L’Hermite, Simoncini and Genazzani at the 6th IMS symposium held in Pisa in December 2006; they can be consulted at www.6thimsworkshop.com. The present work has been, however, considerably extended and updated.
PII: S0378-5122(08)00204-1
doi: 10.1016/j.maturitas.2008.07.007
© 2008 Elsevier Ireland Ltd. All rights reserved.
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Maturitas
Volume 60, Issue 3
, Pages 185-201
, July 2008
