Maturitas
Volume 60, Issue 3 , Pages 248-252 , July 2008

The effect of testosterone alone and testosterone+estradiol therapy on bladder functions and smooth muscle/collagen content in surgically menopause induced rats

  • Filiz Çayan

      Affiliations

    • Department of Obstetrics and Gynecology, University of Mersin School of Medicine, Mersin 33079, Turkey
  • ,
  • Mesut Tek

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin 33079, Turkey
  • ,
  • Ebru Ballı

      Affiliations

    • Department of Histology and Embryology, University of Mersin School of Medicine, Mersin 33079, Turkey
  • ,
  • Sinem Öztuna

      Affiliations

    • Department of Histology and Embryology, University of Mersin School of Medicine, Mersin 33079, Turkey
  • ,
  • Sinan Karazindiyanoğlu

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin 33079, Turkey
  • ,
  • Selahittin Çayan

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin 33079, Turkey
    • Corresponding Author InformationCorresponding author. Fax: +90 324 337 4311.

Received 8 April 2008 ,Revised 3 July 2008 ,Accepted 22 July 2008.

References 

  1. Cardozo L, Robinson D. Special considerations in premenopausal and postmenopausal women with symptoms of overactive bladder. Urology. 2002;60(5 (Suppl. 1)):64–71
  2. Dambros M, Rodrigues Palma PC, Mandarim-de-Lacerda CA, Miyaoka R, Rodrigues Netto N. The effect of ovariectomy and estradiol replacement on collagen and elastic fibers in the bladder of rats. Int Urogynecol J. 2003;14:108–112
  3. Robinson D, Cardozo LD. The role of estrogen in female lower urinary tract dysfunction. Urology. 2003;62(Suppl. 4A):45–51
  4. Cardozo L, Lose G, McClish D, Versi E. A systematic review of the effects of estrogens for symptoms suggestive of overactive bladder. Acta Obstet Gynecol Scand. 2004;83:892–897
  5. Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med. 1993;329:753–756
  6. Flores A, Rodriguez JO, Palfox MT, et al. The acute asymmetric effects of hemiovariectomy on testosterone secretion vary along the estrous cycle. The participation of the cholinergic system. Reprod Biol Endocrinol. 2006;4:11
  7. Stahl F, Gotz F, Dorner G. The influence of fetal adrenals on the androgen levels during brain differentiation in human subjects and rats. Exp Clin Endocrinol. 1991;98:131–139
  8. Çayan S, Canpolat B, Çayan F, et al. The effect of chronic inflammatory condition of the bladder and estrogen replacement therapy on bladder functions and histology in surgically menopause and chronic cystitis induced rats. Neurourol Urodyn. 2006;25:194–201
  9. Liang W, Afshar K, Stothers L, Laher I. The influence of ovariectomy and estrogen replacement on voiding patterns and detrusor muscarinic receptor affinity in the rat. Life Sci. 2002;71:351–362
  10. Longhurst PA, Kauer J, Leggett HRE, Levin RM. The influence of ovariectomy and estradiol replacement on urinary bladder function in rats. J Urol. 1992;148:915–919
  11. Fleischmann N, Christ G, Sclafani T, Melman A. The effect of ovariectomy and long term estrogen replacement on bladder structure and function in the rat. J Urol. 2002;168:1265–1268
  12. Çayan S, Chermansky C, Schlote N, et al. The bladder acellular matrix graft in a rat chemical cystitis model: functional and histologic evaluation. J Urol. 2002;168:798–804
  13. Çayan S, Coskun B, Bozlu M, et al. Botulinum toxin type A may improve bladder function in a rat chemical cystitis model. Urol Res. 2003;30:399–404
  14. Acar D, Çayan S, Aktaş S, Tek M, Akbay E. The effect of tamoxifene on bladder functions and histology, and the role of estrogen receptor beta in a rat chemical cystitis model. Neurourol Urodyn. 2007;26:309–316
  15. Madeiro A, Girao M, Sartori M, Acquaroli R, Baracat E, Rodrigues De Lima G. Effects of the association of androgen/estrogen on the bladder and urethra of castrated rats. Clin Exp Obstet Gynecol. 2002;29:117–120
  16. Lin WY, Rehfusst A, Whitbeck C, et al. Effect of letrozole on urinary bladder function in the female rabbit. BJU Int. 2007;100:1391–1395
  17. Kim NN, Min K, Pessina MA, Munarriz R, Goldstein I, Traish AM. Effects of ovariectomy and steroid hormones on vaginal smooth muscle contractility. Int J Impot Res. 2004;16:43–50
  18. Batra S, Andersson KE. Oestrogen-induced changes in muscarinic receptor density and contractile responses in the female rat urinary bladder. Acta Physiol Scand. 1989;137:135–141
  19. Elliott RA, Castleden CM, Miodrag A, Kirwan P. The direct effects of diethylstilboestrol and nifedipine on the contractile responses of isolated human and rat detrusor muscles. Eur J Clin Pharmacol. 1992;43:149–155
  20. Shenfeld OZ, McCammon KA, Blackmore PF, Ratz PH. Rapid effects of estrogen and progesterone on tone and spontaneous rhythmic contractions of the rabbit bladder. Urol Res. 1999;27:386–392
  21. Fantl JA, Wyman JF, Anderson RL, Matt DW, Bump RC. Postmenopausal urinary incontinence: comparison between non-estrogen-supplemented and estrogen-supplemented women. Obstet Gynecol. 1988;71:823–828
  22. Hall R, Andrews PLR, Hoyle CHV. Effects of testosterone on neuromuscular transmission in rat isolated urinary bladder. Eur J Pharmacol. 2002;449:301–309
  23. Speroff L, Glass RH, Kase NG. Postmenopausal hormone therapy. Clinical gynecologic endocrinology and infertility. 6th ed.. Lippincott Williams & Wilkins; 1999;p 725–79
  24. Davis SR, McCloud P, Strauss BJG, Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas. 1995;21:227–236

PII: S0378-5122(08)00203-X

doi: 10.1016/j.maturitas.2008.07.008

Maturitas
Volume 60, Issue 3 , Pages 248-252 , July 2008