Maturitas
Volume 60, Issue 3 , Pages 230-234 , July 2008

Effects of estradiol on the cognitive function of postmenopausal women

  • Ricardo M. Marinho

      Affiliations

    • Federal University of Sâo Paulo and Faculdade de Ciências Médicas de Minas Gerais, Brazil
    • ,
  • José Maria Soares Jr.

      Affiliations

    • Department of Gynecology, Federal University of Săo Paulo, Brazil
    • Corresponding Author InformationCorresponding author at: Department of Gynecology, Federal University of Săo Paulo, Rua Sena Madureira 1245 Apt., 1104021051 Sâo Paulo, SP, Brazil. Tel.: +55 11 50813685; fax: +55 11 50813685.
    • ,
  • Ricardo C. Santiago

      Affiliations

    • Faculdade de Ciências Médicas de Minas Gerais, Brazil
    • ,
  • Carla C. Maganhin

      Affiliations

    • Department of Gynecology, Federal University of Săo Paulo, Brazil
    • ,
  • Flavia Machado

      Affiliations

    • Faculdade de Ciências Médicas de Minas Gerais, Brazil
    • ,
  • Ana Marcia de Miranda Cota

      Affiliations

    • Faculdade de Ciências Médicas de Minas Gerais, Brazil
    • ,
  • Edmund C. Baracat

      Affiliations

    • Department of Gynecology, Federal University of Săo Paulo, Brazil
    • Departamento de Obstetrícia e Ginecologia - FMUSP, Brazil

Received 6 January 2008 ,Revised 20 May 2008 ,Accepted 13 July 2008.

References 

  1. Henderson V. Hormone therapy and the brain. A clinical perspective on the role of estrogen. New York, NY, USA: The Parthenon Publishing Group Inc.; 1999;
  2. Yaffe K, Sawaya G, Lieberburg I, Grady D. Estrogen therapy in postmenopausal women. Effects on cognitive function and dementia. JAMA. 1998;279:688–695
  3. Sherwin BB. Estrogen and cognitive aging in women. Neuroscience. 2006;138:1021–1026
  4. LeBlanc ES, Janowsky J, Chan BK, Nelson HD. Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA. 2001;285(March 21 (11)):1489–1499
  5. Hogervorst E, Yaffe K, Richards M, Huppert F. Hormone replacement therapy to maintain cognitive function in women with dementia. Cochrane Database Syst Rev. 2002;3:[CD003799]
  6. Hogervorst E, Yaffe K, Richards M, Huppert F. Hormone replacement therapy for cognitive function in postmenopausal women. Cochrane Database Syst Rev. 2002;3:[CD003122]
  7. Shumaker SA, Legault C, Rapp SR, et al. WHIMS investigators, estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA. 2003;289:2651–2662
  8. Leung SW, Teoh H, Keung W, Man RY. Non-genomic vascular actions of female sex hormones: physiological implications and signalling pathways. Clin Exp Pharmacol Physiol. 2007;34:822–826
  9. Skibińska A, Kossut M. Estrogens and synaptic plasticity. Neurol Neurochir Pol. 2003;37:39–50
  10. Craig MC, Murphy DG. Estrogen: effects on normal brain function and neuropsychiatric disorders. Climacteric. 2007;10:97–104
  11. Jelks KB, Wylie R, Floyd CL, McAllister AK, Wise P. Estradiol targets synaptic proteins to induce glutamatergic synapse formation in cultured hippocampal neurons: critical role of estrogen receptor-alpha. J Neurosci. 2007;27:6903–6913
  12. Mulnard RA, Cotman CW, Kawas C, et al. For the Alzheimer's disease cooperative study estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. JAMA. 2000;283:1007–1015
  13. Kernan WN, Brass LM, Viscoli CM, Sarrel PM, Makuch R, Horwitz RI. Estrogen after ischemic stroke: clinical basis and design of the Women's Estrogen for Stroke Trial. J Stroke Cerebrovasc Dis. 1998;7:85–95
  14. Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. Estrogen therapy and risk of cognitive decline: results from the Women's Estrogen for Stroke Trial (WEST). Am J Obstet Gynecol. 2005;192(February (2)):387–393
  15. Polo-Kantola P, Portin R, Polo O, Helenius H, Irjala K, Erkkola R. The effect of short-term estrogen replacement therapy on cognition: a randomized, double-blind, cross-over trial in postmenopausal women. Obstet Gynecol. 1998;91(3):459–465
  16. Drachman DA. Memory and cognitive function in man: does the cholinergic system have a specific role?. Neurology. 1977;27:783–790
  17. Bayles KA. Understanding the neuropsychological syndrome of dementia. Semin Speech Lang. 2001;22:251–259
  18. Kawas CH, Corrada MM, Brookmeyer R, et al. Visual memory predicts Alzheimer's disease more than a decade before diagnosis. Neurology. 2003;60:1089–1093
  19. Nelson HD, Humphrey LL, Nygren P, Teutsch SM, Allan JD. Postmenopausal hormone replacement therapy: scientific review. JAMA. 2002;288(August 21 (7)):872–881
  20. Schneider AM. Stimulus control and spreading cortical depression: some problems reconsidered. Psychol Rev. 1968;75(July (4)):353–358
  21. Matthews K, Cauley J, Yaffe K, Zmuda JM. Estrogen replacement therapy and cognitive decline in older community women. J Am Geriatr Soc. 1999;47:518–523
  22. Smith YR, Love T, Persad CC, Tkaczyk A, Nichols TE, Zubieta JK. Impact of combined estradiol and norethindrone therapy on visuospatial working memory assessed by functional magnetic resonance imaging. J Clin Endocrinol Metab. 2006;91:4476–4481
  23. Grodstein F, Chen J, Pollen DA, et al. Postmenopausal hormone therapy and cognitive function in healthy older women. J Am Geriatr Soc. 2000;48:746–752
  24. Yaffe K, Haan M, Byers A, Tangen C, Kuller L. Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction. Neurology. 2000;54:1949–1954
  25. Espeland MA, Rapp SR, Shumaker SA, et al. Women's Health Initiative Memory Study. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA. 2004;291:2959–2968
  26. Whitmer RA, Haan MN, Miller JW, Yaffe K. Hormone replacement therapy and cognitive performance: the role of homocysteine. J Gerontol A: Biol Sci Med Sci. 2003;58:324–330
  27. Larsen RJ, Mercer KA, Balota DA. Lexical characteristics of words used in emotional Stroop experiments. Emotion. 2006;6:62–72
  28. Maki PM. A systematic review of clinical trials of hormone therapy on cognitive function: effects of age at initiation and progestin use. Ann NY Acad Sci. 2005;1052:182–197

PII: S0378-5122(08)00198-9

doi: 10.1016/j.maturitas.2008.07.003

Maturitas
Volume 60, Issue 3 , Pages 230-234 , July 2008

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