Maturitas
Volume 60, Issue 3 , Pages 209-215 , July 2008

Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague–Dawley rats

  • Dominik Rachoń

      Affiliations

    • Department of Clinical and Experimental Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany
    • Department of Clinical Nutrition, Medical University of Gdańsk, ul. Dębinki 7, 80-211 Gdańsk, Poland
  • ,
  • Tina Vortherms

      Affiliations

    • Department of Clinical and Experimental Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany
  • ,
  • Dana Seidlová-Wuttke

      Affiliations

    • Department of Clinical and Experimental Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany
  • ,
  • Wolfgang Wuttke

      Affiliations

    • Department of Clinical and Experimental Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany
    • Corresponding Author InformationCorresponding author.

Received 2 December 2007 ,Revised 1 May 2008 ,Accepted 3 June 2008.

References 

  1. Bjorntorp P. Obesity and adipose tissue distribution as risk factors for the development of disease. A review. Infusionstherapie. 1990;17:24–27
  2. Folsom AR, Kushi LH, Anderson KE, et al. Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. Arch Intern Med. 2000;160:2117–2128
  3. Speroff L, Rowan J, Symons J, Genant H, Wilborn W. The comparative effect on bone density, endometrium, and lipids of continuous hormones as replacement therapy (CHART study). A randomized controlled trial. JAMA. 1996;276:1397–1403
  4. Sites CK, Calles-Escandon J, Brochu M, Butterfield M, Ashikaga T, Poehlman ET. Relation of regional fat distribution to insulin sensitivity in postmenopausal women. Fertil Steril. 2000;73:61–65
  5. Kannel WB, Cupples LA, Ramaswami R, Stokes JF 3rd, Kreger BE, Higgins M. Regional obesity and risk of cardiovascular disease; the Framingham Study. J Clin Epidemiol. 1991;44:183–190
  6. Despres JP. The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients’ risk. Obes Res. 1998;6(Suppl 1):8S–17S
  7. Tchernof A, Calles-Escandon J, Sites CK, Poehlman ET. Menopause, central body fatness, and insulin resistance: effects of hormone-replacement therapy. Coron Artery Dis. 1998;9:503–511
  8. Seidlova-Wuttke D, Hesse O, Jarry H, et al. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Eur J Endocrinol. 2003;149:351–362
  9. Seidlova-Wuttke D, Jarry H, Becker T, Christoffel V, Wuttke W. Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Maturitas. 2003;44(Suppl 1):S39–S50
  10. Recommendations for estrogen and progestogen use in peri- and postmenopausal women: October 2004 position statement of The North American Menopause Society. Menopause 2004;11:589–600.
  11. Hormone therapy for the prevention of chronic conditions in postmenopausal women: recommendations from the U.S. Preventive Services Task Force. Ann Intern Med 2005;142:855–60.
  12. Newton KM, Buist DS, Keenan NL, Anderson LA, LaCroix AZ. Use of alternative therapies for menopause symptoms: results of a population-based survey. Obstet Gynecol. 2002;100:18–25
  13. Raus K, Brucker C, Gorkow C, Wuttke W. First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055. Menopause. 2006;13:678–691
  14. Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003;44(Suppl 1):S67–S77
  15. Roth C, Schricker M, Lakomek M, et al. Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model. J Endocrinol. 2001;169:361–371
  16. Wuttke W, Gorkow C, Seidlova-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study. Menopause. 2006;13:185–196
  17. Mahady GB. Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. Treat Endocrinol. 2005;4:177–184
  18. Wuttke W, Jarry H, Seidlova-Wuttke D. Cimicifuga racemosa extract for the treatment of climacteric complaints. J Endocrinol Reprod. 2006;10:106–110
  19. Burdette JE, Liu J, Chen SN, et al. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem. 2003;51:5661–5670
  20. Oktem M, Eroglu D, Karahan HB, Taskintuna N, Kuscu E, Zeyneloglu HB. Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial. Adv Ther. 2007;24:448–461
  21. Richter CP, Uhlenhuth EH. Comparison of the effects of gonadectomy of spontaneous activity of wild and domesticated Norway rats. Endocrinology. 1954;54:311–322
  22. Trayhurn P, Hoggard N, Mercer JG, Rayner DV. Hormonal and neuroendocrine regulation of energy balance—the role of leptin. Arch Tierernahr. 1998;51:177–185
  23. Zamboni M, Armellini F, Milani MP, et al. Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships. Int J Obes Relat Metab Disord. 1992;16:495–504
  24. Poehlman ET, Toth MJ, Gardner AW. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med. 1995;123:673–675
  25. Toth MJ, Sites CK, Eltabbakh GH, Poehlman ET. Effect of menopausal status on insulin-stimulated glucose disposal: comparison of middle-aged premenopausal and early postmenopausal women. Diabetes Care. 2000;23:801–806
  26. Espeland MA, Stefanick ML, Kritz-Silverstein D, et al. Effect of postmenopausal hormone therapy on body weight and waist and hip girths. Postmenopausal Estrogen-Progestin Interventions Study Investigators. J Clin Endocrinol Metab. 1997;82:1549–1556
  27. Manson JE, Hsia J, Johnson KC, et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003;349:523–534
  28. Mattiasson I, Rendell M, Tornquist C, Jeppsson S, Hulthen UL. Effects of estrogen replacement therapy on abdominal fat compartments as related to glucose and lipid metabolism in early postmenopausal women. Horm Metab Res. 2002;34:583–588
  29. Gray JM, Wade GN. Food intake, body weight, and adiposity in female rats: actions and interactions of progestins and antiestrogens. Am J Physiol. 1981;240:E474–E481
  30. Pedersen SB, Bruun JM, Kristensen K, Richelsen B. Regulation of UCP1, UCP2, and UCP3 mRNA expression in brown adipose tissue, white adipose tissue, and skeletal muscle in rats by estrogen. Biochem Biophys Res Commun. 2001;288:191–197
  31. Gray JM, Greenwood MR. Effect of estrogen on lipoprotein lipase activity and cytoplasmic progestin binding sites in lean and obese Zucker rats. Proc Soc Exp Biol Med. 1984;175:374–379
  32. Darimont C, Delansorne R, Paris J, Ailhaud G, Negrel R. Influence of estrogenic status on the lipolytic activity of parametrial adipose tissue in vivo: an in situ microdialysis study. Endocrinology. 1997;138:1092–1096
  33. Roy EJ, Wade GN. Role of estrogens in androgen-induced spontaneous activity in male rats. J Comp Physiol Psychol. 1975;89:573–579
  34. Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci USA. 2000;97:12729–12734
  35. Lundeen SG, Carver JM, McKean ML, Winneker RC. Characterization of the ovariectomized rat model for the evaluation of estrogen effects on plasma cholesterol levels. Endocrinology. 1997;138:1552–1558
  36. Windler E, Chao Y, Havel RJ. Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat. J Biol Chem. 1980;255:5475–5480
  37. Hamosh M, Hamosh P. The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue. J Clin Invest. 1975;55:1132–1135
  38. Peinado-Onsurbe J, Staels B, Vanderschueren D, Bouillon R, Auwerx J. Effects of sex steroids on hepatic and lipoprotein lipase activity and mRNA in the rat. Horm Res. 1993;40:184–188
  39. Nappi RE, Malavasi B, Brundu B, Facchinetti F. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol. 2005;20:30–35
  40. van Weerden WM, Bierings HG, Van Steenbrugge GJ, De Jong FH, Schröder FH. Adrenal glands of mouse and rat do not synthesize androgens. Life Sci. 1992;50:857
  41. Ryan AS, Nicklas BJ, Berman DM. Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women. Diabetes Care. 2002;25:127–133
  42. Spencer CP, Godsland IF, Cooper AJ, Ross D, Whitehead MI, Stevenson JC. Effects of oral and transdermal 17beta-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women. Metabolism. 2000;49:742–747
  43. Seidlová-Wuttke D, Jarry H, Wuttke W. Mechanisms of action of antiosteoporotic effects of a special Cimicifuga racemosa (CR) extract: inhibition of the RANK–RANKL–Osteoprotegerin triad. In:  Seidlová-Wuttke D editors. Annual meeting, North American Menopause Society. 2007;
  44. Roche HM. Dietary lipids and gene expression. Biochem Soc Trans. 2004;32:999–1002
  45. Tintut Y, Demer L. Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification. J Investig Med. 2006;54:395–401
  46. Burdette JE, Chen SN, Lu ZZ, et al. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. J Agric Food Chem. 2002;50:7022–7028

PII: S0378-5122(08)00189-8

doi: 10.1016/j.maturitas.2008.06.001

Maturitas
Volume 60, Issue 3 , Pages 209-215 , July 2008