Maturitas
Volume 59, Issue 3 , Pages 268-274 , 20 March 2008

Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps

  • Evrim Erdemoglu

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    • Corresponding Author InformationCorresponding author at: Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Doğu Kampüsü, Çünür 32260, Isparta, Turkey. Tel.: +90 246 2238784; fax: +90 246 2370240.
    • ,
  • Mehmet Güney

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    • ,
  • Nermin Karahan

      Affiliations

    • Department of Pathology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    • ,
  • Tamer Mungan

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

Received 23 March 2007 ,Revised 10 December 2007 ,Accepted 13 February 2008.

References 

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  2. McGurgan P, O’Donovan P, Duffy S. How should we manage endometrial polyps? The yearbook of obstetrics and gynaecology. RCOG Press. 2002;10:348–357
  3. Inceboz US, Nese N, Uyar Y, Ozcakir HT, Kurtul O, Baytur YB. Hormone receptor expressions and proliferation markers in postmenopausal endometrial polyps. Gynecol Obstet Invest. 2006;61(1):24–28
  4. Lurlaro M, Loverro G, Vacca A, Cormio G, Ribatti D, Minischetti M. Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 correlate with upgrading and myometrial invasion in endometrial carcinoma. Eur J Clin Invest. 1999;29(9):793–801
  5. Li W, Xu RJ, Jiang LH, Shi J, Long X, Fan B. Expression of cyclooxygenase-2 and inducible nitric oxide synthase correlates with tumor angiogenesis in endometrial carcinoma. Med Oncol. 2005;22(1):63–70
  6. Graesslin O, Cortez A, Uzan C, Birembaut P, Quereux C, Darai E. Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions. Int J Gynecol Cancer. 2006;16(5):1911–1917
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  13. Maia H, Correia T, Freitas LA, Athayde C, Coutinho E. Cyclooxygenase-2 expression in endometrial polyps during menopause. Gynecol Endocrinol. 2005;21(6):336–339
  14. Taylor LJ, Jackson TL, Reid JG, Duffy SR. The differential expression of oestrogen receptors, progesterone receptors, Bcl-2 and Ki67 in endometrial polyps. BJOG. 2003;110(9):794–798
  15. McGurgan P, Taylor LJ, Duffy SR, O’Donovan PJ . An immunohistochemical comparison of endometrial polyps from postmenopausal women exposed and not exposed to HRT. Maturitas. 2006;20(53(4)):454–461
  16. Galant C, Berliere M, Dubois D, Verougstraete JC, Charles A, Lemoine P. Focal expression and final activity of matrix metalloproteinases may explain irregular dysfunctional endometrial bleeding. Am J Pathol. 2004;165(1):83–94
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  18. Rodgers WH, Matrisian LM, Giudice LC, et al. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest. 1994;94:946–953
  19. Maia H, Correia T, Freitas L, Athayde C, Coutinho EM. Cyclooxygenase-2 expression in the endometrium and its relationship to bleeding in users of continuous oral contraceptives. Gynecol Endocrinol. 2006;22(2):96–100
  20. McGurgan P, Taylor LJ, Duffy SR, O’Donovan PJ. Are endometrial polyps from pre-menopausal women similar to post-menopausal women? An immunohistochemical comparison of endometrial polyps from pre- and post-menopausal women. Maturitas. 2006;54(3):277–284

PII: S0378-5122(08)00045-5

doi: 10.1016/j.maturitas.2008.02.007

Maturitas
Volume 59, Issue 3 , Pages 268-274 , 20 March 2008

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