Maturitas
Volume 58, Issue 2 , Pages 174-181 , 20 October 2007

Pretreatment with phytoestrogen-rich plant decreases breast tumor incidence and exhibits lower profile of mammary ERα and ERβ

  • Wichai Cherdshewasart

      Affiliations

    • Department of Biology, Faculty of Science, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, Thailand
    • Corresponding Author InformationCorresponding author. Tel.: +66 2 2185379; fax: +66 2 2185386.
  • ,
  • Rattana Panriansaen

      Affiliations

    • Program of Biotechnology, Faculty of Science, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, Thailand
  • ,
  • Porntipa Picha

      Affiliations

    • Section of Experimental Oncotherapy, Research Division, National Cancer Institute, Ministry of Public Health, RamaVI Road, Ratchathewi, Bangkok 10400, Thailand

Received 19 May 2007 ,Revised 2 August 2007 ,Accepted 9 August 2007.

References 

  1. Fitzpatrick LA. Soy isoflavones: hope or hype?. Maturitas. 2003;44(Suppl 1):S21–S29
  2. Lamartiniere CA, Moore J, Holland M, et al. Neonatal genistein chemoprevents mammary cancer. Proc Soc Exp Biol Med. 1995;208:120–123
  3. Murrill WB, Brown NM, Zhang J-X, et al. Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis. 1996;17:1451–1457
  4. Hilakivi-Clarke L, Onojafe I, Raygada M, et al. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Br J Cancer. 1999;80:1682–1688
  5. Lamartiniere CA, Murrill WB, Manzolillo PA, et al. Genistein alters the ontogeny of mammary gland development and protects against chemically induced mammary cancer in rats. Proc Soc Exp Biol Med. 1998;217:358–364
  6. Hilakivi-Clarke L, Cho E, Onojafe I, et al. Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol Rep. 1999;6:1089–1095
  7. Kashemsanta MLC, Suvatabhandu K, Airy Shaw HK. A new species of Pueraria (Leguminosae) from Thailand, yielding an oestrogenic principle. Kew Bull. 1952;263–266
  8. Cain JC. Miroestrol; an oestrogen from the plant Pueraria mirifica roots. Nature. 1960;188:774–777
  9. Jones HEH, Pope GS. A method for the isolation of miroestrol from Pueraria mirifica. J Endocrinol. 1961;22:303–312
  10. Jones HEM, Pope GS. A study of the action of miroestrol and other oestrogens on the reproductive tract of the immature female mouse. J Endocrinol. 1960;20:229–235
  11. Benson GK, Cowie AT, Hosking ZD. Mammogenic activity of mirostrol. J Endocrinol. 1961;21:401–409
  12. Chansakaow S, Ishikawa T, Seki H, et al. Identification of deoxymiroestrol as the actual rejuvenation principle of “Kwao Keur”, Pueraria mirifica. The known miroestrol may be an artifact. J Nat Prod. 2000;63:173–175
  13. Cherdshewasart W, Subtang S, Dahlan W. Major isoflavonoid contents of the phytoestrogen-rich herb Pueraria mirifica in comparison with Pueraria lobata. J Pharm Biomed Anal. 2007;43:428–434
  14. Trisomboon H, Malaivijitnond S, Watanabe G, et al. The estrogenic effect of Pueraria mirifica on gonadotrophin levels in aged monkeys. Endocrine. 2006;29:129–134
  15. Trisomboon H, Malaivijitnond S, Cherdshewasart W, et al. The influence of Pueraria mirifica herb containing phytoestrogens on the urinary gonadotropin and estradiol levels in aged menopausal monkeys. Anim Sci J. 2007;78:378–386
  16. Trisomboon H, Malaivijitnond S, Cherdshewasart W, et al. Effect of Pueraria mirifica on the sexual skin coloration of aged menopausal cynomolgus monkeys. J Reprod Dev. 2006;52:537–542
  17. Urasopon N, Hamada Y, Asaoka K, et al. Pueraria mirifica, a phytoestrogen-rich herb, prevents bone loss in orchidectomized rats. Maturitas. 2007;56:322–331
  18. Dweck AC. The Pueraria family with special interest in Pueraria mirifica. Personal Care Mag. 2003;3:7–10
  19. Cherdshewasart W, Cheewasopit W, Picha P. The differential anti-proliferation effect of white (Pueraria mirifica), red (Butea superba), and black (Mucuna collettii) Kwao Krua plants on the growth of MCF-7 cells. J Ethnopharmacol. 2004;93:255–260
  20. Huggins CB, Grand LC, Brillantes FP. Mammary cancer induced by a single feeding of polynuclear hydrocarbons and its suppression. Nature (London). 1961;189:204–207
  21. Chow LWC, Cheung MNB, Loo WTY, et al. A rat cell line derived from DMBA-induced mammary carcinoma. Life Sci. 2003;73:27–40
  22. Young S, Hallowes RC. Tumors of the mammary gland. In: Pathology of tumors in laboratory animals 1. Lyon: IARC; 1973;p. 31–74
  23. Trisomboon H, Malaivijitnond S, Watanabe G, et al. Ovulation block by Pueraria mirifica. Endocrine. 2005;26:31–39
  24. Malaivijitnond S, Kiatthaipipat P, Cherdshewasart W, et al. Different effects of Pueraria mirifica, a herb containing phytoestrogens, on LH and FSH secretion in gonadectomized female and male rats. J Pharm Sci. 2004;96:428–435
  25. Trisomboon H, Malaivijitnond S, Cherdshewasart W, et al. Assessment of urinary gonadotrophin and steroid hormone profiles of female cynomolgus monkeys after treatment with Pueraria mirifica. J Reprod Dev. 2007;53:395–403
  26. Malaivijitnond S, Chansri K, Kijkuokul P, et al. Using vaginal cytology to assess the estrogenic activity of phytoestrogen-rich herbs. J Ethnopharmacol. 2006;107:354–360
  27. Cherdshewasart W, Kitsamai Y, Malaivijitnond S. Estrogenic activity of the wild Pueraria mirifica evaluated by vaginal cornification assay. J Reprod Dev. 2007;53:385–393
  28. Lazennec G, Bresson D, Lucas A, et al. ERβ Inhibits proliferation and invasion of breast cancer cells. Endocrinology. 2001;142:4120–4130
  29. Park BW, Kim KS, Heo MK, et al. Expression of estrogen receptor-β in normal mammary and tumor tissues: is it protective in breast carcinogenesis?. Breast Cancer Res. 2003;80:79–85
  30. Gallo D, Giacomelli S, Cantelmo F, et al. Chemoprevention of DMBA-induced mammary cancer in rats by dietary soy. Breast Cancer Res Treat. 2001;69:153–164
  31. Gustafsson J-Å. Estrogen receptor beta—a new dimension in estrogen mechanism of action. J Endocrinol. 1999;163:379–383
  32. Morito K, Hirose T, Kinjo J, et al. Interaction of phytoestrogen with estrogen α and β. Biol Pharm Bull. 2001;24:351–356
  33. Lee YS, Park JS, Cho SD, et al. Requirement of metabolic activation for estrogenic activity of Pueraria mirifica. J Vet Sci. 2002;3:273–277
  34. Xu X, Harris KS, Wang H-J, et al. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutri. 1995;125:2307–2315
  35. Hwang CS, Kwak HS, Lim HJ, et al. Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration. J Steroid Biochem. 2006;101:246–253
  36. Woclawek-Potocka I, Okuda K, Acosta TJ, et al. Phytoestrogen metabolites are much more active than phytoestrogens themselves in increasing prostaglandin F synthesis via prostaglanin F synthase-like 2 stimulation in bovine endometrium. Prostag Oth Lipid M. 2005;78:202–217
  37. Jeon GC, Park MS, Yoon DY, et al. Antitumor activity of spinasterol isolated from Pueraria roots. Exp Mol Med. 2005;37:111–120
  38. Muangman V, Cherdshewasart W. Clinical trail of the phytoestrogen-rich herb, Pueraria mirifica as a crude drug in the treatment of symptoms in menopausal women. Siriraj Hosp Gaz. 2001;53:300–309
  39. Cornwell T, Cohick W, Raskin I. Dietary phytoestrogens and health. Phytochemistry. 2004;65:995–1016

PII: S0378-5122(07)00240-X

doi: 10.1016/j.maturitas.2007.08.001

Maturitas
Volume 58, Issue 2 , Pages 174-181 , 20 October 2007