Maturitas
Volume 57, Issue 4 , Pages 382-391 , 20 August 2007

Effects of black cohosh on estrogen biosynthesis in normal breast tissue in vitro

  • Petra Stute

      Affiliations

    • Department of Obstetrics and Gynecology, University Clinic of Muenster, 48149 Muenster, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 251 83 48202; fax: +49 251 83 48267.
    • ,
  • Thomas Nisslein

      Affiliations

    • Schaper & Brümmer GmbH & Co. KG, 38259 Salzgitter, Germany
    • ,
  • Martin Götte

      Affiliations

    • Department of Obstetrics and Gynecology, University Clinic of Muenster, 48149 Muenster, Germany
    • ,
  • Axel Kamischke

      Affiliations

    • Department of Obstetrics and Gynecology, St. Barbara Clinic, Hamm, Germany
    • ,
  • Ludwig Kiesel

      Affiliations

    • Department of Obstetrics and Gynecology, University Clinic of Muenster, 48149 Muenster, Germany
    • ,
  • Walter Klockenbusch

      Affiliations

    • Department of Obstetrics and Gynecology, University Clinic of Muenster, 48149 Muenster, Germany

Received 21 November 2006 ,Revised 16 April 2007 ,Accepted 20 April 2007.

References 

  1. McKinney KA, Thompson W. A practical guide to prescribing hormone replacement therapy. Drugs. 1998;56:49–57
  2. Nelson HD, Humphrey LL, Nygren P, Teutsch SM, Allan JD. Postmenopausal hormone replacement therapy: scientific review. JAMA. 2002;288:872–881
  3. North American Menopause Society . Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause. 2004;11(1):11–33
  4. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet. 1997;350:1047–1059
  5. Beral V. Breast cancer and hormone-replacement therapy in the million women study. Lancet. 2003;362:419–427
  6. Chlebowski RT, Hendrix SL, Langer RD, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. J Am Med Assoc. 2003;289:3243–3253
  7. Chen WY, Hankinson SE, Schnitt SJ, Rosner BA, Holmes MD, Colditz GA. Association of hormone replacement therapy to estrogen and progesterone receptor status in invasive breast carcinoma. Cancer. 2004;101:1490–1500
  8. Writing Group for the Women's Health Initiative Investigators . Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled, trial.. J Am Med Assoc. 2002;288:321–333
  9. Liebermann S. A review of the effetiveness of Cimicifuga racemosa (Black Cohosh) for the symptoms of menopause. J Women's Health. 1998;7:525–529
  10. Liske E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders. Adv Nat Ther. 1998;15:45–53
  11. Hostanska K, Nisslein T, Freudenstein J, Reichling J, Saller R. Cimicifuga racemosa extract inhibits proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of apoptosis. Breast Cancer Res Treat. 2004;84:151–160
  12. Hostanska K, Nisslein T, Freudenstein J, Reichling J, Saller R. Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells. Biol Pharm Bull. 2004;27(12):1970–1975
  13. Saxe Einbond L, Shimizu M, Xiao D, et al. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Cancer Res Treat. 2004;83:221–231
  14. Lupu R, Mehmi I, Atlas E, et al. Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth. Int J Oncol. 2003;23(5):1407–1412
  15. Freudenstein J, Dasenbrock C, Nisslein T. Lack of promotion of estrogen-dependent mammary gland tumors in vivo by am isopropanolic Cimicifuga racemosa extract. Cancer Res. 2002;62:3448–3452
  16. Linden Hirschberg A, Edlund M, Svane G, Azavedo E, Skoog L, von Schoultz B. An isopropanolic extract of black cohosh does not increase mammographic breast density or breast cell proliferation in postmenopausal women. Menopause. 2007;14(1):
  17. Suzuki T, Miki Y, Nakamura Y, et al. Sex steroid-producing enzymes in human breast cancer. Endocr Relat Cancer. 2005;12:701–720
  18. Abul-Hajj YJ, Iverson R, Kiang DT. Aromatization of androgens by human breast cancer. Steroids. 1979;33:205–222
  19. Lipton A, Santner SJ, Santen RJ, et al. Aromatase activity in primary and metastatic human breast cancer. Cancer. 1987;59:779–782
  20. Perel E, Daniilescu D, Kharlip L, Blackstein M, Killinger DW. Steroid modulation of aromatase activity in human cultured breast carcinoma cells. J Steroid Biochem. 1988;29:393–399
  21. Dao TL, Hayes C, Libby PR. Steroid sulfatase activities in human breast tumors. Proc Soc Exp Biol Med. 1974;146:381–384
  22. Vignon F, Terqui M, Westley B, Derocq D, Rochefort H. Effects of plasma estrogen sulfates in mammary cancer cells. Endocrinology. 1980;106:1079–1086
  23. Prost O, Turrel MO, Dahan N, Craveur C, Adessi GL. Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma. Cancer Res. 1984;44:661–664
  24. Chapman O, Purohit A, Wang DY, Ghilchik MW, Reed MJ. Oestrone sulphatase activity in normal and malignant breast tissues: relationship with tumour location. Anticancer Res. 1995;15:1467–1471
  25. Chetrite GS, Cortes-Prieto J, Philippe JC, Wright F, Pasqualini JR. Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues. J Steroid Biochem Mol Biol. 2000;72:23–27
  26. MacIndoe JH. The hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate by MCF-7 human breast cancer cells. Endocrinology. 1988;123:1281–1287
  27. Pasqualini JR, Chetrite G, Nestour EL. Control and expression of oestrone sulphatase activities in human breast cancer. J Endocrinol. 1996;150(Suppl):S99–S105
  28. Evans TR, Rowlands MG, Law M, Coombes RC. Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma. Br J Cancer. 1994;69:555–561
  29. Pasqualini JR. Role, control and expression of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase activities in human breast cancer. Zentralbl Gynakol. 1997;119(Suppl 2):48–53
  30. Peltoketo H, Isomaa V, Maentausta O, Vihko R. Complete amino acid sequence of human placental 17beta-hydroxysteroid dehydrogenase deduced from cDNA. FEBS Lett. 1998;239:73–77
  31. Luu-The V, Labrie C, Zhao HF, et al. Characterization of cDNAs for human estradiol 17beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5′-termini in human placenta. Mol Endocrinol. 1989;3:1301–1309
  32. Pasqualini JR, Chetrite G, Nguyen BL, et al. Estrone sulfate-sulfatase and 17 beta-hydroxysteroid dehydrogenase activities: a hypothesis for their role in the evolution of human breast cancer from hormone-dependence to hormone-independence. J Steroid Biochem Mol Biol. 1995;53:407–412
  33. Pasqualini JR, Chetrite G, Blacker C, et al. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. J Clin Endocrinol Metab. 1996;81:1460–1464
  34. Santen RJ, Leszczynski D, Tilson-Mallet N, et al. Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways. Ann NY Acad Sci. 1986;464:126–137
  35. Santner SJ, Feil PD, Santen RJ. In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway. J Clin Endocrinol Metab. 1984;59:29–33
  36. Utsumi T, Yoshimura N, Takeuchi S, et al. Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer. Cancer Res. 1999;59:377–381
  37. Miyoshi Y, Ando A, Hasegawa S, et al. High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer. Clin Cancer Res. 2003;9:2288–2293
  38. Pasqualini JR, Chetrite G. Paradoxical effect of estradiol: it can block its own bioformation in human breast cancer cells. J Steroid Biochem Mol Biol. 2001;78:21–24
  39. Pasqualini JR. Differential effects of progestins on breast tissue enzymes. Maturitas. 2003;46(Suppl 1):S45–S54
  40. Pasqualini JR, Caubel P, Friedman AJ, Philippe JC, Chetrite GS. Norelgestromin as selective estrogen enzyme modulator in human breast cancer cell lines. Effect on sulfatase activity in comparison to medroxyprogesterone acetate. J Steroid Biochem Mol Biol. 2003;84:193–198
  41. Nguyen BL, Chetrite G, Pasqualini JR. Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164, 384, danazol, and promegestone (R-5020). Breast Cancer Res Treat. 1995;34:139–146
  42. Chetrite G, Kloosterboer HJ, Pasqualini JR. Effect of tibolone (ORG OD14) and its metabolites on estrone sulphatase activity in mcf-7 and t-47d mammary cancer cells. Anticancer Res. 1997;17:135–140
  43. Kloosterboer HJ, Schoonen WG, Deckers GH, Klijn JG. Effects of progestagens and org od14 in in vitro and in vivo tumor models. J Steroid Biochem Mol Biol. 1994;49:311–318
  44. Xu B, Kitawaki J, Koshiba H, et al. Differential effects of progestogens, by type and regimen, on estrogen-metabolizing enzymes in human breast cancer cells. Maturitas. 2007;56(2):142–152
  45. Stute P, Götte M, Kiesel L. Differential effect of hormone therapy on E1S-sulfatase activity in non-malignant and cancerous breast cells in vitro, Breast Cancer Res Treat, 2007, in press.
  46. Stute P, Register TC, Blair R, Cline JM. Effects of tibolone on estrogen biosynthesis in the mammary tissue of postmenopausal monkeys. Menopause. 2006;13:232–240
  47. Stute P, Szuwart T, Schlueter M, Packeisen J, Kiesel L. Effects of hormone therapy on estrogen biosynthesis in the mammary gland of postmenopausal women, submitted for publication.
  48. Stein C, Hille A, Seidel J, et al. Cloning and expression of human steroid-sulfatase. J Biol Chem. 1989;264:13865–13872
  49. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding. Anal Biochem. 1976;72:248–254
  50. Sonntag B, Götte M, Wülfing P, Schüring A, Kiesel L, Greb R. Metformin alters insulin signaling and viability of human granulosa cells. Fertil Steril. 2005;84(Suppl 2):1173–1179
  51. Sugawara T, Nomura E, Hoshi N. Both N-terminal and C-terminal regions of steroid sulfatase are important for enzyme activity. J Endocrinol. 2006;188:365–374
  52. Russo J, Russo IH. Molecular basis of breast cancer. Prevention and treatment. 1st ed.. Berlin: Springer; 2003;
  53. Söderqvist G, Olsson H, Wilking N, von Schoultz B, Carlstrom K. Metabolism of estrone sulfate by normal breast tissue: influence of menopausal status and oral contraceptives. J Steroid Biochem Mol Biol. 1994;48:221–224
  54. Hawkins RA, Thomson ML, Killen E. Oestrone sulphate, adipose tissue, and breast cancer. Breast Cancer Res Treat. 1985;6:75–87
  55. Tseng L, Mazella J, Lee LY, Stone ML. Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma. J Steroid Biochem. 1983;19:1413–1417
  56. Hobkirk R. Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles. Can J Biochem Cell Biol. 1985;63:1127–1144
  57. Chatterton RT, Geiger AS, Gann PH, Khan SA. Formation of estrone and estradiol from estrone sulfate by normal breast parenchymal tissue. J Steroid Biochem Mol Biol. 2003;86:159–166
  58. Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin H-H. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005;105:1074–1083
  59. Evans TR, Rowlands MG, Luqmani YA, Chander SK, Coombes RC. Detection of breast cancer-associated estrone sulfatase in breast cancer biopsies and cell lines using polymerase chain reaction. J Steroid Biochem Mol Biol. 1993;46:195–201
  60. Chetrite GS, Kloosterboer HJ, Philippe JC, Pasqualini JR. Effects of Org OD14 (Livial) and its metabolites on 17 beta-hydroxysteroid dehydrogenase activity in hormone-dependent MCF-7 and T-47D breast cancer cells. Anticancer Res. 1999;19:261–267
  61. Chetrite GS, Pasqualini JR. The selective estrogen enzyme modulator (SEEM) in breast cancer. J Steroid Biochem Mol Biol. 2001;76:95–104
  62. Henneicke-von Zepelin HH, Meden H, Kostev K, Schröder-Bernhardi D, Stammwitz U, Becher H. Isopropanolic black cohosh extract and recurrence-free survival after breast cancer. Int J Clin Pharmacol Ther. 2007;45(3):143–154

PII: S0378-5122(07)00162-4

doi: 10.1016/j.maturitas.2007.04.007

Maturitas
Volume 57, Issue 4 , Pages 382-391 , 20 August 2007

Article Tools

* Image Usage & Resolution