Maturitas
Volume 57, Issue 1 , Pages 35-38 , 20 May 2007

Tibolone for prevention and treatment of postmenopausal osteoporosis

References 

  1. Lindsay R, Hart A. Prospective double-blind trial of synthetic steroid (Org OD 14) for preventing postmenopausal osteoporosis. Br J Med. 1980;280:1207–1209
  2. Modelska K, Cummings S. Tibolone for postmenopausal women: systematic review of randomized trials. J Clin Endocrinol Metab. 2002;87:16–23
  3. Berning B, van Kuijk JW, Bennink HJ, Kicovic PM, Fauser BC. Effects of two doses of tibolone on trabecular and cortical bone loss in early postmenopausal women: a two-year randomized, placebo-controlled study. Bone. 1996;19:395–399
  4. Gallagher J, Baylink DJ, McClung M. Prevention of bone loss with tibolone in postmenopausal women: results of two randomized, double-blind, placebo-controlled, dose-finding studies. J Clin Endocrinol Metab. 2001;86:4717–4726
  5. Geusens P, Dequeker J, Schot LP. Non-linear increase in vertebral density induced by synthetic steroid (Org OD 14) in women with established osteoporosis. Maturitas. 1991;13:155–162
  6. Bjarnason N, Bjarnason J, Rosenquist C, Christiansen C. Tibolone: prevention of bone loss in late postmenopausal women. J Clin Endocrinol Metab. 1996;81:2419–2422
  7. Bjarnason N, Bjarnason J, Christiansen C. The response in spinal bone mass to tibolone treatment is related to bone turnover in elderly women. Bone. 1997;20:151–155
  8. Banks E, Beral V, Reeves G, Balkwill A, Barnes I, for the Million Women Study Collaborators. Fracture incidence in relation to the pattern of hormone therapy in postmenopausal women. JAMA 2004;291:2212–2220.
  9. Cummings SR. LIFT study is discontinued. [Letter to the Editor] BMJ 2006;332:667.
  10. Gambacciani M, Ciaponi M, Cappagli B, et al. A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in early postmenopausal women. Gynecol Endocrinol. 2004;18:9–16
  11. Swanson SG, Drosman S, Helmond FA, Stathopoulos VM. Tibolone for the treatment of moderate to severe vasomotor symptoms and genital atrophy in postmenopausal women: a multi-center, randomized, double-blind, placebo-controlled study. Menopause. 2006;13:917–925
  12. Roux C, Pelissier C, Fechtenbaum J, Loiseau-Peres S, Benhamou CL. Randomized, double-masked 2-year comparison of tibolone with 17beta-estradiol and norethindrone acetate in preventing postmenopausal bone loss. Osteoporos Int. 2002;13:241–248

PII: S0378-5122(07)00069-2

doi: 10.1016/j.maturitas.2007.02.008

Maturitas
Volume 57, Issue 1 , Pages 35-38 , 20 May 2007

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