Maturitas
Volume 57, Issue 1 , Pages 23-26, 20 May 2007

Estrogen, estrogen treatment and the post-reproductive woman's brain

  • Frederick Naftolin

      Affiliations

    • Department of Obstetrics and Gynecology New York University, New York 10016, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • Dolores Malaspina

      Affiliations

    • Department of Psychiatry New York University, New York 10016, USA

published online 09 March 2007.

Abstract 

From early embryonic life to death, estrogen is a primary regulator of brain neurogenesis and cell number, synaptogenesis and synaptolysis, multiple cognitive and autonomic functions, vascular function, immune responses and defense measures against brain lesions and dystrophy. Although recent attention has focused on the roles of estrogen during the climacteric, knowing estrogen's role in brain development and reproductive function is necessary to understand what happens when this powerful influence is removed during the climacteric. This review will therefore address the full picture, with stress on the later-life role of estrogen in the brain.

Keywords: Estrogen, Woman's brain, Estrogen receptors

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PII: S0378-5122(07)00066-7

doi:10.1016/j.maturitas.2007.02.005

Maturitas
Volume 57, Issue 1 , Pages 23-26, 20 May 2007

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