Maturitas
Volume 56, Issue 2 , Pages 190-197 , 20 February 2007

Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps

  • Giovanna Giordano

      Affiliations

    • Department of Pathology and Medicine of Laboratory, Section of Pathology, Parma University, Viale A. Gramsci 14, 43100 Parma, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0521 290391; fax: +39 0521 292710.
    • ,
  • Letizia Gnetti

      Affiliations

    • Department of Pathology and Medicine of Laboratory, Section of Pathology, Parma University, Viale A. Gramsci 14, 43100 Parma, Italy
    • ,
  • Carla Merisio

      Affiliations

    • Department of Obstetric and Gynecologic Sciences and Neonatology, Parma University, Italy
    • ,
  • Mauro Melpignano

      Affiliations

    • Department of Obstetric and Gynecologic Sciences and Neonatology, Parma University, Italy

Received 4 April 2006 ,Revised 21 July 2006 ,Accepted 4 August 2006.

References 

  1. Schlaen I, Bergeron C, Ferenczy A, Wong P, Naves A. Endometrial polyps: a study of 204 cases. Surg Pathol. 1988;1:375–382
  2. Goldstein SR, Monteagudo A, Popiolek D, Mayberry P, Timor-Tritsch I. Evaluation of endometrial polyps. Am J Obstet Gynecol. 2002;186(4):669–674
  3. Caspi B, Goldchmit R, Zalel Y, Appelman Z, Insler V. Sonographically guided aspiration of ovarian cyst with simple appearance. J Ultrasound Med. 1996;15(4):297–300
  4. Cohen MA, Sauer MV, Keltz M, Lindheim SR. Utilizing routine sonohysterography to detect intrauterine pathology before initiating hormone replacement therapy. Menopause. 1999;6(1):68–70
  5. Van den Bosch T, Van Schoubroeck D, Ameye L, De Brabanter J, Van Huffel S, Timmerman D. Ultrasound assessment of endometrial thickness and endometrial polyps in women on hormonal replacement therapy. Am J Obstet Gynecol. 2003;188(5):1249–1253
  6. Sant’Ana de Almeida EC, Nogueira AA, Candido dos Reis FJ, Zambelli Ramalo LN, Zucoloto S. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women. Maturitas. 2004;49(3):229–233
  7. Nomikos IN, Elemenoglou J, Papatheophanis J. Tamoxifen-induced endometrial polyp. A case report and review of the literature. Eur J Gynaecol Oncol. 1998;19(5):476–478
  8. Silva EG, Jenkins R. Serous carcinoma in endometrial polyps. Mod Pathol. 1990;3(2):120–128
  9. Folk JJ, Mazur MT, Eddy GL, Musa AG. Secretory endometrial adenocarcinoma in a patient on tamoxifen for breast cancer: a report of a case. Gynecol Oncol. 1995;58(1):133–135
  10. Schlesinger C, Silverberg SG. Tamoxifen-associated polyps (basalomas) arising in multiple endometriotic foci: a case report and review of the literature. Gynecol Oncol. 1999;73(2):305–311
  11. Ramondetta LM, Sherwood JB, Dunton CJ, Palazzo JP. Endometrial cancer in polyps associated with tamoxifen use. Am J Obstet Gynecol. 1999;180(2 Part 1):340–341Feb
  12. Yamazawa K, Matsui H, Ishikura H, Seki K, Sekiya S. Clear cell adenocarcinoma within a tamoxifen-related polyp. Acta Obstet Gynecol Scand. 2002;81(10):985–987
  13. McCluggage WG, Sumathi VP, McManus DT. Uterine serous carcinoma and endometrial intraepithelial carcinoma arising in endometrial polyps: report of 5 cases, including 2 associated with tamoxifen therapy. Hum Pathol. 2003;34(9):939–943
  14. Hachisuga T, Miyakawa T, Tsujioka H, Horiuchi S, Emoto M, Kawarabayashi T. K-ras mutation in tamoxifen-related endometrial polyps. Cancer. 2003;98(9):1890–1897
  15. Ben-Arie A, Goldchmit C, Laviv Y, et al. The malignant potential of endometrial polyps. Eur J Obstet Gynecol Reprod Biol. 2004;115(2):206–210
  16. Shushan A, Revel A, Rojansky N. How often are endometrial polyps malignant?. Gynecol Obstet Invest. 2004;58(4):212–215
  17. Farrell R, Scurry J, Otton G, Hacker NF. Clinicopathologic review of malignant polyps in stage 1A carcinoma of the endometrium. Gynecol Oncol. 2005;98(2):254–262
  18. Mbatsogo BA, Le Bouedec G, Michy T, Bourdel N, Fouilloux G, Dauplat J. Endometrial cancers arising in polyps associated with tamoxifen use. Gynecol Obstet Fertil. 2005;33(12):975–979
  19. Hileeto D, Fadare O, Martel M, Zheng W. Age dependent association of endometrial polyps with increased risk of cancer involvement. World J Surg Oncol. 2005;3(1):8–13
  20. Chandrasekharan NV, Simmons DL. The cyclooxygenases. Genome Biol. 2004;5:241–247
  21. Liu XH, Kirschnbaum A, Yao S, Lee R, Holland JF, Levine AC. Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth o prostate cancer in vivo. J Urol. 2000;164:820–825
  22. Rozic JG, Chakraborty C, Lala PK. Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesis. Int J Cancer. 2001;93:497–506
  23. Ferrandina G, Legge F, Ranelletti FO, et al. Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome. Cancer. 2002;95:801–807
  24. Wen WH, Reles A. Runnebaum IB et al. p53 mutations and expression in ovarian cancer: correlation with overall survival. Int J Gynecol Pathol. 1999;18(1):29–41
  25. Kupryjanczyk J, Thor AD, Beauchamp R, Poremba C, Scully RE, Yandell DW. Ovarian, peritoneal, and endometrial serous carcinoma: clonal origin of multifocal disease. Mod Pathol. 1996;9(3):166–173
  26. Soslow RA, Pirog E, Isacson C. Endometrial intraepithelial carcinoma with associated peritoneal carcinomatosis. Am J Surg Pathol. 2000;24(5):726–732

PII: S0378-5122(06)00286-6

doi: 10.1016/j.maturitas.2006.08.002

Maturitas
Volume 56, Issue 2 , Pages 190-197 , 20 February 2007

Article Tools

* Image Usage & Resolution