Maturitas
Volume 55 , Pages S64-S74 , 1 November 2006

Contrasting effects of estradiol, testosterone and of a black cohosh extract on density, mechanical properties and expression of several genes in the metaphysis of the tibia and on fat tissue of orchidectomized rats

  • D. Seidlová-Wuttke

      Affiliations

    • Department of Clinical and Experimental Endocrinology, University of Göttingen, Germany
    • ,
  • K.M. Stürmer

      Affiliations

    • Department of Traumatology, University of Göttingen, Germany
    • ,
  • E.K. Stürmer

      Affiliations

    • Department of Traumatology, University of Göttingen, Germany
    • ,
  • S. Sehmisch

      Affiliations

    • Department of Traumatology, University of Göttingen, Germany
    • ,
  • W. Wuttke

      Affiliations

    • Department of Clinical and Experimental Endocrinology, University of Göttingen, Germany
    • Corresponding Author InformationCorresponding author at: Abt. Klin. und Exp. Endokrinologie, Universitäts-Frauenklinik Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany. Tel.: +49 551 396714; fax: +49 551 396518.

References 

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  2. Mayes JS, Watson GH. Direct effects of sex steroid hormones on adipose tissues and obesity. Obes Rev. 2004;5:197–216
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  4. Seidlova-Wuttke D, Hesse O, Jarry H, et al. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Eur J Endocrinol. 2003;149:351–362
  5. Seidlova-Wuttke D, Jarry H, Pitzel L, Wuttke W. Effects of estradiol-17β, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats. Maturitas. 2005;51:177–186
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  9. Hall JM, Couse JF, Korach KS. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem. 2001;276:36869–36872
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  12. Sturmer EK, Seidlova-Wuttke D, Sehmisch S, et al. Standardized bending and breaking test for the normal and osteoporotic metaphyseal tibias of the rat: effect of estradiol, testosterone, and raloxifene. J Bone Miner Res. 2006;21:89–96
  13. Kawano S, Kambe F, Ohmori S, Kanda K, Nagaya T, Seo H. Effect of estrogen and tail-suspension on expression of osteocalcin mRNA in femur of ovariectomized rats. Environ Med. 2000;44:82–84
  14. Spelsberg TC, Subramaniam M, Riggs BL, Khosla S. The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol Endocrinol. 1999;13:819–828
  15. Helterbrand JD, Higgs RE, Iversen PW, Tysarczyk-Niemeyer G, Sato M. Application of automatic image segmentation to tibiae and vertebrae from ovariectomized rats. Bone. 1997;21:401–409
  16. Ek-Rylander B, Bill P, Norgard M, Nilsson S, Andersson G. Cloning, sequence, and developmental expression of a type 5, tartrate-resistant, acid phosphatase of rat bone. J Biol Chem. 1991;266:24684–24689
  17. van der Eerden BC, Lowik CW, Wit JM, Karperien M. Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. J Endocrinol. 2004;180:457–467
  18. Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003;44(Suppl 1):S67–S77
  19. Gennari L, Nuti R, Bilezikian JP. Aromatase activity and bone homeostasis in men. J Clin Endocrinol Metab. 2004;89:5898–5907
  20. Murata Y, Robertson KM, Jones ME, Simpson ER. Effect of estrogen deficiency in the male: the ArKO mouse model. Mol Cell Endocrinol. 2002;193:7–12
  21. Lindberg MK, Vandenput L, Moverare Skrtic S, et al. Androgens and the skeleton. Minerva Endocrinol. 2005;30:15–25
  22. Windahl SH, Andersson G, Gustafsson JA. Elucidation of estrogen receptor function in bone with the use of mouse models. Trends Endocrinol Metab. 2002;13:195–200
  23. Goss PE, Qi S, Cheung AM, Hu H, Mendes M, Pritzker KP. Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats. Clin Cancer Res. 2004;10:5717–5723
  24. Van Der Eerden BC, Van De Ven J, Lowik CW, Wit JM, Karperien M. Sex steroid metabolism in the tibial growth plate of the rat. Endocrinology. 2002;143:4048–4055
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  26. Wiren KM, Zhang XW, Toombs AR, et al. Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals. Endocrinology. 2004;145:3507–3522
  27. Jarry H, Metten M, Spengler B, Christoffel V, Wuttke W. In vitro effects of the Cimicifuga racemosa extract BNO. Maturitas. 2003;44(Suppl 1):S31–S38
  28. Jarry H, Thelen P, Christoffel V, Spengler B, Wuttke W. Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP. Phytomedicine. 2005;12:178–182
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PII: S0378-5122(06)00240-4

doi: 10.1016/j.maturitas.2006.06.018

Maturitas
Volume 55 , Pages S64-S74 , 1 November 2006

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