Maturitas
Volume 55 , Pages S26-S36 , 1 November 2006

In vitro assays for bioactivity-guided isolation of endocrine active compounds in Vitex agnus-castus

  • Hubertus Jarry

      Affiliations

    • Department of Clinical and Experimental Endocrinology, Georg-August-University, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 551 396522; fax: +49 551 396518.
    • ,
  • Barbara Spengler

      Affiliations

    • Bionorica AG, Neumarkt, Germany
    • ,
  • Wolfgang Wuttke

      Affiliations

    • Department of Clinical and Experimental Endocrinology, Georg-August-University, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany
    • ,
  • Volker Christoffel

      Affiliations

    • Bionorica AG, Neumarkt, Germany

References 

  1. Lurie S, Borenstein R. The premenstrual syndrome. Obstet Gynecol Surv. 1990;45:220–228
  2. Leong DA, Frawley LS, Neill JD. Neuroendocrine control of prolactin secretion. Ann Rev Physiol. 1983;45:109–127
  3. Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova-Wuttke D. Chaste tree ( Vitex agnus-castus) – pharmacology and clinical indications. Phytomedicine. 2003;10:348–357
  4. Gorkow C, Wuttke W, Maerz RW. Effectiveness of Vitex agnus-castus preparations. Wien Med Wochenschr. 2002;152:364–372
  5. Halaska M, Beles P, Gorkow C, Sieder C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus-castus extract: results of a placebo-controlled double-blind study. The Breast. 1999;8:175–181
  6. Jarry H, Leonhardt S, Gorkow C, Wuttke W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of agnus-castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol. 1994;102:448–454
  7. Jarry H, Kühn U, Ludwig ML, Wuttke W, Spengler B, Christoffel V. First evidence for estrogenic compounds in Vitex agnus-castus: effects on in vitro steroid secretion from human granulosa and porcine luteal cells. J Menopause. 2000;7(Suppl. 4):12
  8. Dixon-Shanies D, Shaikh N. Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncol Rep. 1999;6:1383–1387
  9. Ben-Jonathan N. Dopamine: a prolactin-inhibiting hormone. Endocr Rev. 1985;6:564–589
  10. Longchampt JE, Hayano M, Ehrenstin M, Dorman RI. Comparison of the uterotrophic activities of various steroids with their utilization in in vitro estrogen biosynthetic systems. Endocrinology. 1960;67:843–848
  11. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA. 1996;93:5925–5930
  12. Schlecht C, Klammer H, Jarry H, Wuttke W. Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats. Toxicology. 2004;205:123–130
  13. Jarry H, Harnischfeger G, Düker E. Studies on the endocrine effects of the contents of Cimicifuga racemosa. 2. In vitro binding of compounds to estrogen receptors. Planta medica. 1985;51:316–319
  14. Niswender GD, Middley AR, Meites J. Radioimmunoassay for rat prolactin. Proc Soc Exp Biol Med. 1969;130:793–797
  15. Hoberg E, Orjala J, Meier B, Sticher O. Diterpenoids from the fruits of Vitex agnus-castus. Phytochemistry. 1999;52:1555–1558
  16. Koehler KF, Helguero LA, Haldosen LA, Warner M, Gustafsson JA. Reflections on the discovery and significance of estrogen receptor beta. Endocr Rev. 2005;26:465–478
  17. Imamov O, Shim GJ, Warner M, Gustafsson JA. Estrogen receptor beta in health and disease. Biol Reprod. 2005;73:866–871
  18. Niswender GD, Middley AR, Monroe SE, Reichert LE. Radioimmunoassay for rat luteinizing hormone with antiovine LH serum and LH J-131. Proc Soc Exp Biol Med. 1968;128:807–811

PII: S0378-5122(06)00236-2

doi: 10.1016/j.maturitas.2006.06.014

Maturitas
Volume 55 , Pages S26-S36 , 1 November 2006

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