Maturitas
Volume 55, Issue 3 , Pages 270-277 , 20 October 2006

Soy protein and bone mineral density in older men and women: A randomized trial

  • K.M. Newton

      Affiliations

    • Group Health Cooperative, Seattle, WA, USA
    • Department of Epidemiology, University of Washington, Seattle, WA, USA
    • Corresponding Author InformationCorresponding author at: Center for Health Studies, Group Health Cooperative, 1730 Minor Ave., Ste 1600, Seattle, WA 98101, USA. Tel.: +1 206 287 2973; fax: +1 206 287 2871.
    • ,
  • A.Z. LaCroix

      Affiliations

    • Group Health Cooperative, Seattle, WA, USA
    • Department of Epidemiology, University of Washington, Seattle, WA, USA
    • Fred Hutchinson Cancer Research Center, USA
    • ,
  • L. Levy

      Affiliations

    • Fred Hutchinson Cancer Research Center, USA
    • ,
  • S.S. Li

      Affiliations

    • Fred Hutchinson Cancer Research Center, USA
    • ,
  • P. Qu

      Affiliations

    • Group Health Cooperative, Seattle, WA, USA
    • ,
  • J.D. Potter

      Affiliations

    • Department of Epidemiology, University of Washington, Seattle, WA, USA
    • Fred Hutchinson Cancer Research Center, USA
    • ,
  • J.W. Lampe

      Affiliations

    • Department of Epidemiology, University of Washington, Seattle, WA, USA
    • Fred Hutchinson Cancer Research Center, USA

Received 19 August 2005 ,Revised 12 April 2006 ,Accepted 15 April 2006.

References 

  1. Lampe JW, Levy L, Li SS, Qu P, Newton KM, LaCroix AZ. Effects of soy protein supplementation on spine and hip bone mineral density in an older population in a randomized controlled trial. J Nutr. 2004;134:1289S
  2. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA. 1998;280:605–613
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  16. Ishimi Y, Yoshida M, Wakimoto S, et al. Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male mice. Bone. 2002;31:180–185
  17. Wu J, Wang XX, Chiba H, et al. Combined intervention of exercise and genistein prevented androgen deficiency-induced bone loss in mice. J Appl Physiol. 2003;94:335–342
  18. Adams KF, Lampe PD, Newton KM, et al. Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial. Am J Clin Nutr. 2005;82:620–626
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  22. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr. 2000;72:844–852
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  24. Lee CA, Einhorn TA. The bone organ system: form and function. In:  Marcus R,  Feldman D,  Kelsey Je editor. Osteoporosis. vol. 1:San Diego: Academic Press; 2001;p. 3–20(Chapter 1)
  25. Chen YM, Ho SC, Lam SS, Ho SS, Woo JL. Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial. Menopause. 2004;11:246–254
  26. Khalil DA, Lucas EA, Juma S, Smith BJ, Payton ME, Arjmandi BH. Soy protein supplementation increases serum insulin-like growth factor-I in young and old men but does not affect markers of bone metabolism. J Nutr. 2002;132:2605–2608
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  28. Chiechi LM, Secreto G, D’Amore M, et al. Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial. Maturitas. 2002;42:295–300
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☆ Presented at the Fifth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, September 2003, Orlando, FL [1].

PII: S0378-5122(06)00131-9

doi: 10.1016/j.maturitas.2006.04.011

Maturitas
Volume 55, Issue 3 , Pages 270-277 , 20 October 2006

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