Maturitas
Volume 55, Issue 3 , Pages 203-211 , 20 October 2006

Isoflavone therapy for menopausal flushes: A systematic review and meta-analysis

  • Laurence G. Howes

      Affiliations

    • Department of Cardiology and Cardiovascular Medicine, Griffith University School of Medicine, and Bond University School of Medicine, Gold Coast Hospital, Nerang St., Southport, Qld 4215, Australia
    • Previously performed contractual work and been a consultant for Novogen Pty Ltd, a manufacturer of Red Clover isoflavone supplements.
    • Corresponding Author InformationCorresponding author. Tel.: +61 7 55198979; fax: +61 7 55198696.
  • ,
  • Jan B. Howes

      Affiliations

    • Menopause Solutions Pty Ltd., High St, Southport, Qld 4215, Australia
    • Previous employee of Novogen Pty Ltd.
  • ,
  • David C. Knight

      Affiliations

    • Caroline Chisholm Centre for Women and Children, Liverpool Hospital, Liverpool, NSW 2170, Australia
    • Previously performed consultancy work for Novogen Pty Ltd.

Received 28 December 2005 ,Revised 22 March 2006 ,Accepted 25 March 2006.

References 

  1. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med. 2002;137:805–813
  2. Huntley AL, Ernst E. Soy for the treatment of perimenopausal symptoms—a systematic review. Maturitas. 2004;47:1–9
  3. Huntley AL, Ernst E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. Menopause. 2003;10:465–476
  4. Messina M, Hughes C. Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency. J Med Food. 2003;6:1–11
  5. Rosenthal R. Meta-analytic procedures for social research. Beverly Hills, CA: Sage; 1984;
  6. van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas. 2002;42:187–193
  7. Knight DC, Howes JB, Eden JA. The effect of Promensil, an isoflavone extract, on menopausal symptoms. Climacteric. 1999;2:79–84[see comment]
  8. Tice JA, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings SR. Phytoestrogen supplements for the treatment of hot flashes: the isoflavone clover extract (ICE) study: a randomized controlled trial. JAMA. 2003;290:207–214
  9. Jeri AR. The use of an isoflavone supplement to relieve hot flushes. Female Patient. 2002;27:47–49
  10. Atkinson C, Warren RM, Sala E, et al. Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial. Breast Cancer Res. 2004;6:R170–R179
  11. Albertazzi P, Pansini F, Bonaccorsi G, Zanotti L, Forini E, De Aloysio D. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol. 1998;91:6–11
  12. Han KK, Soares JM, Haidar MA, de Lima GR, Baracat EC. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet Gynecol. 2002;99:389–394
  13. Faure ED, Chantre P, Mares P. Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study. Menopause. 2002;9:329–334
  14. Penotti M, Fabio E, Modena AB, Rinaldi M, Omodei U, Vigano P. Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Fertil Steril. 2003;79:1112–1117
  15. Upmalis DH, Lobo R, Bradley L, Warren M, Cone FL, Lamia CA. Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause. 2000;7:236–242
  16. Knight DC, Howes JB, Eden JA, Howes LG. Effects on menopausal symptoms and acceptability of isoflavone-containing soy powder dietary supplementation. Climacteric. 2001;4:13–18
  17. Colacurci N, Zarcone R, Borrelli A, et al. Effects of soy isoflavones on menopausal neurovegetative symptoms. Minerva Ginecol. 2004;56:407–412
  18. Murkies AL, Lombard C, Strauss BJ, Wilcox G, Burger HG, Morton MS. Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat. Maturitas. 1995;21:189–195
  19. St Germain A, Peterson CT, Robinson JG, Alekel DL. Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. Menopause. 2001;8:17–26
  20. Scambia G, Mango D, Signorile PG, et al. Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Menopause. 2000;7:105–111
  21. Burke GL, Legault C, Anthony M, et al. Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study. Menopause. 2003;10:147–153
  22. Van Patten CL, Olivotto IA, Chambers GK, et al. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol. 2002;20:1449–1455
  23. Baird DD, Umbach DM, Lansdell L, et al. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab. 1995;80:1685–1690
  24. Russo R, Corosu R. The clinical use of a preparation based on phyto-oestrogens in the treatment of menopausal disorders. Acta Bio Med Ateneo Parmense. 2003;74:137–143
  25. Balk JL, Whiteside DA, Naus G, DeFerrari E, Roberts JM. A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium. J Soc Gynecol Invest. 2002;9:238–242
  26. Kotsopoulos D, Dalais FS, Liang YL, McGrath BP, Teede HJ. The effects of soy protein containing phytoestrogens on menopausal symptoms in postmenopausal women. Climacteric. 2000;3:161–167
  27. Secreto G, Chiechi LM, Amadori A, et al. Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study. Maturitas. 2004;47:11–20
  28. Nahas EP, Neto JN, De Luca L, Traiman P, Pontes A, Dalben I. Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas. 2004;48:372–380
  29. Dalais FS, Rice GE, Wahlqvist ML, et al. Effects of dietary phytoestrogens in postmenopausal women. Climacteric. 1998;1:124–129
  30. Washburn S, Burke GL, Morgan T, Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause. 1999;6:7–13
  31. Baber RJ, Templeman C, Morton T, Kelly GE, West L. Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. Climacteric. 1999;2:85–92
  32. Uesugi S, Watanabe S, Ishiwata N, Uehara M, Ouchi K. Effects of isoflavone supplements on bone metabolic markers and climacteric symptoms in Japanese women. Biofactors. 2004;22:221–228
  33. MacGregor CA, Canney PA, Patterson G, McDonald R, Paul J. A randomised double-blind controlled trial of oral soy supplements verses placebo for treatment of menopausal symptoms in patients with early breast cancer. Eur J Cancer. 2005;41:708–714
  34. Quella SK, Loprinzi CL, Barton DL, et al. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial. J Clin Oncol. 2000;18:1068–1074
  35. Lukaczer D, Darland G, Tripp M, et al. Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. Altern Ther Health Med. 2005;11:60–65
  36. Anonymous . Treatment of menopause-associated vasomotor symptoms: position statement of the North American Menopause Society. Menopause. 2004;11:11–33
  37. National Institutes of Health . National Institutes of Health State-of-the-Science Conference statement: management of menopause-related symptoms. Ann Intern Med. 2005;142:1003–1013
  38. Krebs EE, Ensrud KE, MacDonald R, Wilt TJ. Phytoestrogens for treatment of menopausal symptoms: a systematic review. Obstet Gynecol. 2004;104:824–836
  39. MacLennan A, Lester S, Moore V. Oral oestrogen replacement therapy verses placebo for hot flushes (Cochrane Review). Cochrane Database Sys Rev. 2001;1:CD002978

PII: S0378-5122(06)00099-5

doi: 10.1016/j.maturitas.2006.03.008

Maturitas
Volume 55, Issue 3 , Pages 203-211 , 20 October 2006