Maturitas
Volume 41, Issue 3 , Pages 211-221 , 25 March 2002

Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women

Received 28 July 2000 ,Revised 7 February 2001 ,Accepted 14 September 2001.

References 

  1. Kanis JA. Risk factors in osteoporosis. Maturitas. 1998;30:229–233
  2. Ushiroyama T, Okamura S, Ikeda A, Ueki M. Efficacy of ipriflavone and 1α vitamin D therapy for the cessation of vertebral bone loss. Int. J. Gynecol. Obstet. 1995;48:283–288
  3. Netelenbos C. Osteoporosis: intervention options. Maturitas. 1998;30:235–239
  4. Watts NB, Becker P. Alendronate increases spine and hip bone mineral density in women with postmenopausal osteoporosis who failed to respond to intermittent cyclical etidronate. Bone. 1999;24:65–68
  5. Rozenberg S, Vandromme J, Ayata NB, Filippidis M, Kroll M. Osteoporosis management. Int. J. Fertil. Womens Med. 1999;44:241–249
  6. Watts NB. Postmenipausal osteoporosis. Obstet. Gynecol. Surv. 1999;54:532–538
  7. Celotti F, Bignamini A. Dietary calcium and mineral/vitamin supplementation: a controversial problem. J. Int. Med. Res. 1999;27:1–14
  8. New SA. Bone health: the role of micronutrients. Br. Med. Bull. 1999;55:619–633
  9. Meunier PJ. Calcium, vitamin D and vitamin K in the prevention of fractures due to osteoporosis. Osteoporosis Int. 1999;2:S48–S52
  10. Matsunaga S, Ito H, Sakou T. The effect of vitamin K and D supplementation on ovariectomy-induced bone loss. Calcif. Tissue Int. 1999;65:285–289
  11. Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc. Nutr. Soc. 1997;56:915–937
  12. Orimo H, Fujita T, Onomura T, Inoue T, Kushida K, Shiraki M. Clinical evaluation of Ea-0167 (Menatetrenone) in the treatment of osteoporosis. Clin. Eval. (In Japanese). 1992;20:45–100
  13. Sato Y, Honda Y, Kuno H, Oizumi K. Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. Bone. 1998;23:291–296
  14. Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA. Vitamin K intake and hip fractures in women: a prospective study. Am. J. Clin. Nutr. 1999;69:74–79
  15. Sato Y, Tsuru T, Oizumi K, Kaji M. Vitamin K deficiency and osteopenia in disuse-affected limbs of vitamin D-deficient elderly stroke patients. Am. J. Physiol. Med. Rehabil. 1999;78:317–322
  16. Lian JB, Gundberg CM. Osteocalcin—biochemical considerations and clinical applications. Chin. Orthopaed. 1988;226:267–291
  17. Orishige H. Clinical evaluation of menaquinone versus alfacalcidol in the treatment of osteoporosis: a double-blind, controlled Phase III clinical trial. Clin. Eval. 1992;20:45–100
  18. Akiyama Y. Research on the mechanism of inhibitory action of vitamin K2 on bone resorption in cultured organ culture. J. Jpn. Soc. Bone Min. Metab. 1991;9:239
  19. Koshihara Y. Establishment of human osteoblastic cells derived from periosteum in culture. In Vitro Cell Dev. Biol. 1989;25:37–43
  20. Anderson JJ, Rondano P, Holmes A. Roles of diet and physical activity in the prevention of osteoporosis. Scand. J. Rheumatol. Suppl. 1996;103:65–74
  21. Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA. Vitamin K intake and hip fractures in women: a prospective study. Am. J. Clin. Nutr. 1999;69:74–79
  22. Kamezawa K. Inhibitory effects of combined treatment with vitamin K and D on bone loss of ovariectomized rats: a microradiographic study. Fukuoka Igaku Zasshi. 1999;90:71–78
  23. Douglas AS, Robins SP, Hutchinson JD, Porter RW, Stewart A, Reid DM. Carboxylation of osteocalcin in postmenopausal osteoporotic women following vitamin K and D supplementation. Bone. 1995;17:15–20
  24. Orimo H, Sugioka Y, Fukunaga M, Muto Y, Hokokebuchi T, Gorai I, et al. Diagnostic criteria of primary osteoporosis. J. Bone Miner. Metab. 1998;16:139–150
  25. Eyre DR, Dickson IR, Van Ness KP. Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues. Biochem. J. 1988;252:495–500
  26. Kuwada M, Katayama K. A high-performance liquid chromatographic method for the simultaneous determination of γ-carboxyglutamic acid and glutamic acid in proteins, bone, and urine. Anal. Biochem. 1981;117:259–265
  27. Koshihara Y. Current topics in vitamin K research: promotion of bone formation. Vitamin. 1998;72:641–644
  28. Iwamoto I, Kosha S, Noguchi S, Murakami M, Fujino T, Douchi T, et al. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women: a comparative study with vitamin D3 and estrogen–progestin therapy. Maturitas. 1999;31:161–164
  29. Somekawa Y, Chigugi M, Harada M, Ishibashi T. Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide. J. Clin. Endocrinol. Metab. 1999;84:2700–2704
  30. Akedo Y, Hosoi T, Inoue S. Vitamin K2 modulates proliferation and function of osteoblastic cells in vitro. Biochem. Biophys. Res. Commun. 1992;187:814–820
  31. Mehta AB, Mclntyre N. Haematological disorders in liver disease. Forum Genova. 1998;8:8–25
  32. Andrew M. The relevance of developmental hemostasis to hemorrhagic disorders of newborns. Semin. Perinatol. 1997;21:70–85
  33. Ronden JE, Groenen van Dooren MM, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997;11:61–67

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Maturitas
Volume 41, Issue 3 , Pages 211-221 , 25 March 2002

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